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A Naessens

Publications and source records attributed to A Naessens.

44 records · Page 3Linked to original sources
PubMed1985

Activated T-cells with suppressor/cytotoxic phenotype in acute Toxoplasma gondii infection.

The mononuclear cells in the peripheral blood of 17 adults with acute phase toxoplasmosis were characterized with monoclonal antibodies. The absolute number of lymphocytes was increased by the presence of high numbers of T-cells with a surface phenotype of T-cytotoxic/suppressor cells (OKT3+, OKT8+). Shortly after the onset of the infection these cells expressed activation antigens (OKT10+, OKIa+). These changes were more pronounced in patients with lymphadenopathy, but were also present in those without symptoms of the disease. The activation antigens disappeared in the first weeks after onset of the disease but the reversed OKT4/OKT8 ratio persisted for 2 to 4 months. It generally normalized in parallel with clinical recovery of the patients. In one patient, however, a reversed OKT4/OKT8 ratio was present for more than 1 year after the disappearance of the symptoms.

Adult↗
PubMed1984

Congenital toxoplasmosis: a prospective survey in Brussels.

A prospective survey of antenatal patients was made at a hospital in Brussels over the period 1979-1982 to assess the incidence of congenital toxoplasmosis. Of 2986 patients assessed, 1403 (47%) had no toxoplasma antibodies and were at risk. The susceptible population was assessed every 6 weeks and 20 of these women (1.4%) seroconverted during pregnancy. Ten of the seroconverters had a therapeutic abortion; of the remaining 10 two gave birth to congenitally infected infants. Of the 1583 (53%) patients with a positive serology for toxoplasmosis initially, 17 (1.1%) had high antibody titres indicating that the infection could have taken place early in pregnancy. Nine infants born to these women were followed at our hospital and two of them were affected.

Adult↗
PubMed1983

[Evaluation of ceftriaxone (R013-9904) in the treatment of septicemia caused by gram-negative bacilli].

Thirty-four patients admitted for a suspicion of septicaemia were treated with ceftriaxone, a third generation cephalosporin. Ceftriaxone was administered IV at a dose of 2 grams daily, either as a single injection of 2 g or as two injections of 1 g each. 43 organisms were isolated from the blood of the 34 patients: 20 E.coli; 5 Klebsiella; 2 Salmonella; 2 indole positives Proteus; 1 indole negative Proteus; 1 Enterobacter; 2 Acinetobacter; 3 Staphylococcus aureus; 2 Streptococcus; 1 Enterococcus; 1 Meningococcus and 3 anaerobes. The MIC of the enterobacteria for ceftriaxone ranged from less than or equal to 0.097 microgram/ml to 1.56 microgram/ml. Only two staphylococci, one Acinetobacter and the enterococcus were resistant to the drug. Serum assays of ceftriaxone were performed on the second day of treatment for 15 patients. Within the group treated with a single dosis of 2 g per day, the blood levels were: maximal level (10 min, after the injection): 175 to 460 micrograms/ml (average: 315), minimal level (before injection) 12 to 100 micrograms/ml (average 53). Among the patients treated with two doses of 1 g per day, we obtained: maximal levels 121 to 260 micrograms/ml (average 178), minimal levels 31 to 70 micrograms/ml (average 52). A clinically favorable evolution was obtained for 29 patients (85%). In the cases of 4 patients, the antibiotherapy had to be adapted in view of the susceptibility of the organisms isolated. Ceftriaxone was very well tolerated. The only observed secondary effect was a drug fever occurring in 3 patients who remained febrile in spite of a general improvement.

Bacteria↗
PubMed1983

Prophylactic antibiotics in surgery.

Prospective double blind studies have demonstrated that brief courses of antibiotics active against major contaminating bacterial pathogens are effective in certain surgical interventions if these agents are given prior to surgery. Administration of antibiotics for long periods after surgery has no beneficial effect on the postoperative infection rate. In addition it may increase the risk of adverse effects and results in widespread emergence of resistant organisms. Until now brief courses of antimicrobial agents have not resulted in an increasing number of resistant bacteria, however surveillance must be continued (Acta anaesth. belg., 1983, 34, 163-171).

Anti-Bacterial Agents↗