Biomedical subjects

A Nakatsu

Publications and source records attributed to A Nakatsu.

5 recordsLinked to original sources

PubMed2000

Complete nucleotide sequence of Northern cereal mosaic virus and its genome organization.

We determined the complete nucleotide sequence, 13, 222 nucleotides (nts) of the Northern cereal mosaic virus (NCMV). The genome had 273 nt 5' trailer sequence and 90nts 3' leader sequence. It formed a terminal complementarity in 25 nts of both terminal sequences. A characteristic intergenic sequence (consensus) separating genes, 3'-AUUCUUUUUGACUCUAGU-5' was presented. The genome had nine open reading frames (ORFs) on the viral complementary sequence. Five putative proteins of NCMV were postulated by its molecular weight or comparison of the similarities to other rhabdovirus proteins: nucleocapsid (N), non-structural protein or phosphoprotein (P), matrix protein (M), glycoprotein (G), and polymerase (L). A series of four small ORFs (genes 3 to 6) were also presented between P and M gene sequences. The proposed NCMV genome organization was 3'leader-N-P-3-4-5-6-M-G-L-5'trailer. N and L proteins of NCMV had low but distinct similarities to those of lettuce necrotic yellows virus and Sonchus yellow net virus, respectively.

Edible Grain↗

PubMed1995

Effect of cataract surgery on aqueous turnover and blood-aqueous barrier.

We evaluated changes in aqueous outflow and blood-aqueous barrier (BAB) disruption after cataract surgery in two randomly selected groups of eyes. In one group, a high-viscosity viscoelastic was used for intraocular lens (IOL) implantation; in the other, a low-viscosity viscoelastic. Fluorophotometry was used to evaluate aqueous humor dynamics five to seven hours after IOL implantation. Aqueous outflow after IOL implantation in operated eyes was nearly twice that in the fellow eyes, which served as controls. Mean protein concentration in the anterior chamber was also elevated in operated eyes. However, postoperative aqueous outflow did not differ significantly between the two groups. The substantial increase in aqueous outflow observed postoperatively and the increase in aqueous humor protein concentration were closely related to BAB disruption. These results suggest that BAB disruption may be a main cause of the transient high intraocular pressure observed after IOL implantation in both groups.

Aged↗

PubMed1995

A method of image analysis for primary angle closure glaucoma.

The anterior segment of the eye is displayed on the video monitor using a slitlamp apparatus (slitlamp 75SL, Zeiss, Germany) combined with a video camera and the video image is then analyzed with a computer to convert the optimal image into the true image. The profile of the true image of the anterior eye segment allows us to estimate the pupil-blocking force, which is the posteriorly directed vector exerted in the iris tissue, according to Mapstone's theory. In mensuration by digitizer on 3 occasions from a single video image of a given normal eye, the Pbf was -0.0255 +/- 0.0011 lambda (= Young's module). And the pupil-blocking force of 10 procedures in a given glaucomatous eye was +1.092 +/- 0.018 lambda.

Anterior Eye Segment↗

PubMed1995

Retinal detachment in patients with atopic dermatitis. 5-year retrospective survey.

We surveyed data collected in our department over the past 5 years on all patients under the age of 30 years who had presented for repair of retinal detachment. Of 52 such patients, 10 (19.2%) had a documented history of atopic dermatitis. Three (27.3%) of the 11 eyes (10 patients) with atopic dermatitis exhibited a break in the ciliary epithelium in the pars plicata and pars plana, the most characteristic finding in this group. Surgical reattachment of the retina was accomplished in all 11 eyes. To repair a tear in the ciliary epithelium in atopic cases, we prefer using an encircling procedure to reconstruct an artificial ora serrata.

Adult↗

PubMed1994

Long-term results of trabeculotomy ab externo.

We retrospectively reviewed the records of patients followed for over 4 years after undergoing trabeculotomy to treat primary open-angle glaucoma (POAG) to evaluate the long-term effects of the procedure on intraocular pressure (IOP) control. IOP remained below 15 mm Hg, with no need for postoperative medication in 7 (13.2%) of 53 eyes. IOP was below 15 mm Hg in an additional eight eyes (15.1%) treated with topical medication. Topical medication was needed to maintain IOP between 16 to 20 mm Hg in 23 eyes (43.4%). Oral acetazolamide or additional surgery was needed in 15 (28.3%). A postoperative IOP below 20 mm Hg with or without topical medication was associated with a survival probability of 71.2%. Our results demonstrated that, although trabeculotomy largely failed to maintain an "ideal" postoperative IOP (below 15 mm Hg), it was not associated with severe operative or postoperative complications such as flat anterior chamber. Thus, the procedure probably should be the first choice not only in uncomplicated cases of congenital glaucoma and pseudoexfoliation glaucoma (as previously established), but also in cases of POAG in young patients with only slight damage to the optic disc or visual field and cases with forward movement of the iris-lens diaphragm.

Adult↗