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Biomedical subjects

A Neidhardt

Publications and source records attributed to A Neidhardt.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Programmed injection of liquid volatile anesthetics into the system. A plea for a tightly closed circuit].

Severinghaus et Lowe have given us a precise means of knowing what the patient's anaesthetic needs are under volatile anaesthesia. The parameters of the well-known formula for calculating the unit dose, Qan = 2 [Qc (dl).lambda.1.3 MAC], are recorded in the microprocessor of a computerized syringe: 1) the patient's body weight to the power 0.75 and multiplied by 2, i.e. cardiac output (Qc); 2) the nature of the selected volatile, i.e. the product of elements other than the Qc. The microprocessor calculates also the rate per minute according to the information obtained from the clock and the principle that the rate of anaesthetic is inversely proportional to the square root of the time the anaesthesia lasts. A numerical panel gives information on the following: injection time, injected anaesthetic volume per minute, cumulative quantity of liquid anaesthetic injected. The syringe is set in such a manner as to face upwards to prevent the development of bubbles. A rapidly stable alveolar concentration is obtained, proving Lowe right.

Anesthesia, Closed-Circuit↗
PubMed1987

[Propofol and thoracic surgery].

20 patients undergoing thoracic surgery were studied. Before anaesthesia either a catheter was placed in the intercostal space, at the same level as the thoracotomy (16 patients) or an epidural catheter was inserted if there was a contraindication of intercostal blockade (4 patients). Marcaine 0.5--was injected. Anaesthesia was induced with propofol 2.5 mg.kg-1, vecuronium 0.1 mg.kg-1, dextromoramide 50 mcg.kg-1. It was maintained with propofol 9 mg.kg-1.h-1 for 30 mn, then 4.5 mg.kg-1.h-1 for following hours (by a syringe pump) and vecuronium 0.1 mg.kg-1.h-1. Cardio vascular effects were studied only in the 16 patients with intercostal blockade: during induction bradycardia in 3 patients, and systolic arterial pressure (S.A.P.) decrease of 30% in 8 patients were observed. After the incision, heart rate and S.A.P. became steady. The average duration of anaesthesia was 214 min +/- 74. The time from the end of propofol infusion to the moment of extubation was 15.4 min +/- 33 and the time to recover all mental faculties was 46 mn +/- 11. 30 min after the end of anaesthesia the maxima minute ventilation was equal to the post operative value at 48 H. Propofol anaesthesia allows a fast awakening, without cumulative effects.

Anesthesia Recovery Period↗
PubMed1986

[Action of ifenprodil tartrate in obliterative arteriopathies of the lower limbs. Combined studies using proximal blood flow and distal transcutaneous oxygen pressure].

A simultaneous analysis of both the variations of the flow in the stenosis artery and the distal PO2, was carried out during an injection of an alpha-blocker: the Tartrate d'Ifenprodil, on twenty-five patients afflicted with occlusive disease of the lower limbs requiring surgery. The measurements were taken under general anaesthesia, before any surgical operation, the hemodynamic and ventilatory balance being monitored by radial manometry and arterial gas analysis. We observe an increase of proximal arterial flow and at the same time an improvement of the distal TcPO2. Moreover, the variations of microcirculation flow measured by TcPO2 are correlated with proximal flow variations, this relation: delta TcPO2 = K delta Q + A is more true in the first and the second stages of Fontaine. With the same (Tartrate d'Ifenprodil) posology, the distal benefit measured by transcutaneous oximetry is less important in advanced stages compared with other stages (everything else being equal). The transcutaneous measurement of the distal oxygen pressure, allows an objective view of microcirculatory improvement obtained by a vasoactive substance (ifenprodil tartrate) considering the specific nature of each patient arteriopathy.

Adult↗
PubMed1986

[Filter circuits and pollution].

The contamination of air of a 50 m3 operating room has been analyzed after three and half hours of halothane enaesthesia with a closed circle system and an opened system. The analysis has been made by gaz chromatography. Concentrations of Halothane found during the use of an opened system are 100 to 120 times the allowable norms in U.S.A. After using the closed circle system, the analysis of air does not reveale any trace of Halothane.

Air Pollution↗
PubMed1984

[Hypocaloric nutrition or strict protein intake in the postoperative period].

The purpose of this study was to verify the statements of Blackburn concerning the positive effects of strict nitrogen hypocaloric diets. Three groups of 10 postoperative patients received hypocaloric diets. A carbohydrate diet of 200 grams was given to the first series of patients, a nitrogen diet of 12.4 to the second and finally a carbohydrate-protein diet consisting of 200 grams Sorbitol and 12.4 grams nitrogen to the third. Patients were followed for five days. The existence of post-aggression reactions was determined through measurements of GH, Cortisol, glycemia, insulinemia, fatty acids and ketone bodies. Patients under the strict nitrogen diet presented a less elevated hyperglycemia than the other groups. Insulinemia was also lower with values returning to normal by the second day. This same group showed a significant rise of free fatty acids with ketonemia, an obvious sign of lipolysis. The respiratory quotient, near 0.7, was also indicative of lipolysis. The cumulative nitrogen balance over five days was much less negative than for patients under a strictly carbohydrate diet: the nitrogen balance closest to zero was however obtained for patients under the carbohydrate-protein diet. The combined analysis of the respiratory quotient and the nitrogen balance allowed an evaluation of the respective participation of lipid and carbohydrate nutriments to the energy supply in function of the three types of diet. Lipid participation was of 36% under the carbohydrate diet, 48% under the carbohydrate-protein diet and 84% under the strictly protein diet.

Blood Chemical Analysis↗