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Biomedical subjects

A Neidhardt

Publications and source records attributed to A Neidhardt.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Effect of cytidine diphosphate choline on anoxia tolerance of cultured myocardial cells.

Three series of cultured Wistar rat heart cells (10 treated and 10 controls x 3) were examined with a laser contraction-meter in a special chamber for anoxia to determine whether cytidine diphosphate choline (CDPC), a membrane phospholipid precursor, can protect against total oxygen deprivation. Heart rate and force of contraction (inotropism) were monitored during a 40-minute period of hypoxia. CDPC in a concentration of 142 micrograms/ml-1 was added to the culture medium only during the anoxia period in series I, during the 3 days of culture in series II, and during the 3 days of culture and the 40-minute hypoxia period in series III. In series I, inotropism decreased by 21% versus 55% in control group (P less than 0.05). In series II, inotropism decreased by 25% versus 43% in control group (P less than 0.05). In series III, inotropism decreased by 22% versus 44% in control group (P less than 0.05). Compared with control cells, cells treated with CDPC during anoxia maintained a significantly greater inotropic state. The effect is greatest if the cells are weak, as in series I. CDPC may be a useful component of the cardioplegic mixture during cardiopulmonary bypass and in the treatment of myocardial ischemia.

Animals↗
PubMedDate not supplied

[Supra-umbilical laparotomies and perturbed pulmonary blood oxygenation (author's transl)].

Pulmonary blood flow and ventilation were studied in twenty three patients after supra-umbilical laparotomy by means of samplings of blood gases and expiratory air content, spirometry, and pneumotachography. Although ventilatory perturbations predominate (notably, a lessened tidal volume and an amputation of the residual functional capacity they are found in conjunction with perfusion anomalies, an shown by the study of O2 and CO2 ductances). The PCO2/PO2 diagram of Rahn and Fenn further illustrates these perfusion alterations; in addition, it gives an impression of the metabolic orientation of the patients in the early post-operative period. Several physiopathological notions are derived from the study, as well as some therapeutic proposals.

Adult↗