A case of treatment of an advanced ovarian adenocarcinoma (Stage IIIc of the FIGO) is reported. The patient underwent a maximal tumor reduction followed with polychemotherapy. After this treatment, a "second look" laparotomy shows an incomplete remission. An intensive chemotherapy with abdomini-pelvic radiotherapy and protection of medullary toxicity by a bone marrow autograft is performed, with a satisfactory result, without relapse, 16 months after this treatment (or 25 months after the first laparotomy). A review of the literature concerning the treatment to be undertaken following the "second look" operation, is briefly exposed. Reasons which led the authors to perform an autograft and mostly the conditions under which this treatment may be offered, are then presented.

Adult↗

PubMed1987

[Genetic factors in the development of bronchial cancer. Apropos of a pair of identical twins].

An anaplastic bronchial cancer was observed to occur simultaneously in identical twin brothers, with a rapidly fatal outcome. This led to authors to appraise the prevalence of such cases and to study the role of genetic factors in the determining bronchial cancer. A review of the literature has not revealed an identical case, on the other hand 4 twin pairs suffered from a bronchial cancer with a different histology (3 epidermoid and 1 bronchoalveolar) were reported. Familial cases of bronchial cancer were also recorded. The authors go on to allude to the intervention of genetic factors in the defense mechanisms of the lung: mucociliary clearance, immunological defense and the role of aryl hydrocarbon hydroxylase. The precise identification of these factors remains difficult on account of their interaction with environmental factors.

Bronchial Neoplasms↗

PubMed1987

[12-year development of non-excreting multicentric plasmacytoma with amyloidosis].

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Adult↗

PubMed1983

[Cardiac involvement in Friedreich's disease: importance of non-invasive cardiologic investigations. Apropos of 13 cases].

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Adult↗

PubMed1977

[Clinical and biochemical study of 2 cases of lipomatosis].

The authors report two cases of lipomatosis. Biochemical study of lipomas revealed, in comparison with normal adipose tissue:--an increase in lipasic lipoprotein activity;--a decrease in lipasic triglyceride activity. These changes could be in part implicated in the mechanisms of fatty accumulation within the lipomas, without explaining the topography and encapsulation.

Adipose Tissue↗

PubMed1975