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A Nespolo

Publications and source records attributed to A Nespolo.

51 records · Page 3Linked to original sources
PubMed1987

Prognostic value of cerebrospinal fluid electrophoresis in optic neuritis and suspected multiple sclerosis.

The prognostic significance of cerebrospinal fluid electrophoresis and IgG-index has been investigated in 44 patients, of whom 10 had optic neuritis and 34 suspected, possible or probable multiple sclerosis. The predictive value of CSF oligoclonal banding for future disease dissemination is very high in the suspected multiple sclerosis subgroup, where after a follow-up of 4.4 years, 7 out of 7 band-positive patients displayed further disease activity. The absence of CSF oligoclonal bands seems to carry a relatively benign short-term (follow-up 3.4 years) prognosis in suspected MS cases.

Adult↗
PubMed1986

Cryptococcal meningoencephalitis: intrathecal immunological response.

The intrathecal immune response is reported in a patient with cryptococcal meningoencephalitis. CSF IgM and IgG levels were significantly related to the favourable clinical evolution. IgM response was specifically directed against the pathological agent, while IgG were mostly non-specific. The data are discussed and compared with the other chronic infections of the central nervous system.

Adolescent↗
PubMed1984

CFS oligoclonal bands in MS and other neurological diseases detected by agarose isoelectric focusing and electrophoresis.

Agarose gel isoelectric focusing (IEF) and electrophoresis (EF) were compared for detection of CSF oligoclonal bands in multiple sclerosis (MS) and other neurological diseases. The CSF IgG/albumin ratio, the IgG-Index and the IgG synthesis per day in the CNS were also considered. IEF was highly sensitive, revealing oligoclonal bands in 100% of CSF from 40 clinically definite MS, while EF had a sensitivity of 70%. In 90 patients with other neurological diseases, IEF revealed oligoclonal bands in 25.5%, EF in 11.1%. The IgG-index was the most sensitive of the quantitative parameters.

Adolescent↗
PubMed1982

Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules.

The effects of an oral enteric-coated preparation (VAL 579 capsules) of sodium valproate (VPA) were compared with those of conventional oral and rectal preparations in 24 epileptic patients. Enteric-coated capsules are useful for avoiding gastric intolerance to VPA. Plasma VPA level peaks after the enteric- coated form were later than after other forms. The bioavailability appeared to be the same for all the forms.

Adolescent↗
PubMed1981

Myasthenia gravis. Anti-acetylcholine receptor antibodies.

Human acetylcholine receptor and the Lefvert method (13) were used to determine the serum levels of anti-acetylcholine receptor antibodies in 27 patients with Myasthenia Gravis. Antibodies were detected in 22 patients (81%). Negative results were generally obtained in patients having milder forms of the disease. To find out whether serum levels of antibodies correlate with the severity of the disease, we compared the median antibody levels in patients with Type 1 and 2A Myasthenia Gravis with those of patients with type 2B and 3. Significantly lower titers were observed in the first group. Nevertheless, there were many overlapping values in the range of each class of the disease. A more definite relationship was observed in the follow-up of single patients. As a rule, clinical deterioration was accompanied by an increase of antibody levels and viceversa.

Adult↗
PubMed1981

[Polyacrylamide gel disc electrophoresis in the study of cerebrospinal fluid proteins in inflammatory diseases of the central nervous system Preliminary results].

The present study was designed to evaluate the potential of polyacrylamide disc electrophoresis of CSF proteins as an adjunct to laboratory diagnosis of neurological inflammatory diseases. The results of polyacrylamide and cellulose acetate electrophoresis of 42 CSF samples from control subjects and patients with various inflammatory diseases of CNS are presented. A comparison between results from both techniques is made. The polyacrylamide disc electrophoresis has been found valuable in the study of liquoral proteins with particular attention to gammaglobulins because this resolving power is superior to the other method. However, the Authors emphasize the importance of distinguishing the genetically determined proteins and haptoglobins and of the use of specific criteria in interpretation of a CSF protein pattern.

Cerebrospinal Fluid Proteins↗
PubMedDate not supplied

Short and medium-term influence of physical activity on immune parameters.

Physical stress induces different changes in immune parameters depending on effort schedule and/or customary physical training. The mechanisms whereby they take place and the occurrence of possible tolerance after repeated effort have not been conclusively elucidated. We studied short and medium-term exercise-induced changes in immune parameters after a standard physical effort (24' of cycle ergometer up to the 80% of maximal heart rate, daily for 5 days) in a group of healthy untrained controls. White Blood Cells, lymphocyte subsets, plasmatic catecholamine and cortisol levels, IgG and IL2receptor (IL2R) levels were determined. Most of the observed changes were strictly acute effort-related and disappeared within 3 hours (except for shifts in CD4+ CD45RA+ and CD4+ CD45RA- lymphocytes): they were concomitant to a transient sympathetic activation proved by heart rate (HR) and Norepinephrine (NE) increase. The medium-term effects of repeated daily effort included only a questionable rise in CD19+ and CD3+ CD4- CD8- cells. As far as possible tolerance mechanisms are concerned, we did not detect any change in either the direction or the entity of effort-induced changes in our controls after repeated effort. Study of strictly standardized exercise protocols is mandatory before clinical applications of physical activity in the approach to the treatment of disimmune diseases.

Adult↗