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Biomedical subjects

A Nikulin

Publications and source records attributed to A Nikulin.

At least 37 records · Page 2Linked to original sources
PubMed1984

Electron microscopic study of fingernails in the disease of Mljet (Mal de Meleda).

Results are presented of the electron-microscopic examinations of fingernail clippings from 4 patients suffering from Mljet (Mal de Meleda) disease, of 3 obligate heterozygotes of this autosomal recessively inherited disease, as well as of 3 controls. In the nails of the diseased persons, significantly more osmiophilic material was found than in those of controls. In the nails of heterozygotes, the findings were intermediate between those of patients and controls. In the nails of aged persons, a strongly osmiophilic matrix keratin was found. Histochemically, lipids were demonstrated in the ventral plate of diseased nails. The probable significance and implications of these findings are discussed.

Adult↗
PubMed1984

Lactate dehydrogenase isoenzymes in human malignant tumors.

For estimation of the value of Chemetron method for LD isoenzyme separation on cellulose-acetate membranes in cancer tissues taken from corpses, malignant tumors revealed by autopsy were investigated. Overall stability of LD, as well as the maintenance of various forms of isoenzymes in the extracts with regard to post-mortem autolysis in corpse and long periods of freezing, have been demonstrated. No correlation was found between the degree of isoenzyme changes and the histologic grading of tumors. LD isoenzyme pattern in cancer metastasis has been considered with respect to vascular and metabolic role of the environmental normal tissue. In order to point out the possible role of LD isoenzyme pattern in cancer diagnosis a lot of preliminary studies has been reviewed. The clarification of the specific distribution of LD activities in different tissues has been considered.

Bronchial Neoplasms↗
PubMed1983

[So-called malacoplakia of the testis and epididymis].

We report on a case of malacoplakia involving testis and epididymis in 63-year-old man. The lesion had a characteristic yellow nodular gross appearance and was composed of histiocytes, neutrophils and plasma cells. Calcospherules (Michaelis-Gutmann bodies) are prominent. The findings are compatible with the generally accepted concept that malacoplakia represents a peculiar inflammatory process of unknown etiology. The relationship between testicular malacoplakia and granulomatous orchitis is discussed.

Epididymis↗
PubMed1982

[Ultrastructure of rabbit myocardium in experimental histamine shock].

The ultrastructure of rabbit myocardium was studied after experimental histamine release by Polymyxin-B-sulphate. As soon as 15 minutes after the histamine release mitochondria and sarcoplasmic reticulum showed alterations with appearance of lysosomes and partial destruction of contractile structures. The sarcolemm formed blistered protrusions with simultaneously expelled cytoplasmic elements. Whereas intramural vessels were inconspicuous, the pericapillar spaces showed a considerable enlargement. On the basis of these findings, we suppose that the changes were induced on the one hand by the increase of the permeability of capillaries produced by histamine and, on the other one, by local and general ischemia as a consequence of shock.

Animals↗
PubMed1981

Pancreatic lesions in shock and their significance.

The pancreas was examined histologically in 146 cases of patients dying of shock. The finding of morphological evidence of disseminated intravascular coagulation (DIC) in the pancreas supports the opinion that the pancreas in highly sensitive to disturbances of blood perfusion. The presence of DIC combined with a variety of pathological lesions in the exocrine ad endocrine pancreas was sufficiently characteristic to justify use of the term " shock pancreatitis". The relative scarcity of data hitherto available on pathological changes in the pancreas caused by shock can be ascribed to changes in the management of shock. It is concluded that the pancreatic lesions described in this study could influence the outcome in shock treated by modern methods of resuscitation.

Disseminated Intravascular Coagulation↗
PubMed1980

[Ultrastructure of liver cells during experimental histamine shock (author's transl)].

An light and electronmicroscopic study of the rabbit hepatocytes during shock after experimental histamine release by Polymyxin-B-sulphate was made. As soon as five minutes after the histamine liberation the endoplasmatic reticulum becomes dissociated and the mitochondria show a spherical transformation. When the shock lasts up to one hour the changes are more intensive. The rest of deteriorated mitochondria and the endoplasmic membranes are expelled from the cells into the sinusoid lumina in form of myelinic figures. The hepatocyte microvilli swell up at first, and later, from the fifteenth minute after the beginning of shock they disappear which results in the flattening of the plasma membrane or its complete dissapearance in some places. Endothelial cells suffer similar alterations and they also acquire cytoplasmic protrusions. The findings lead to the conclusion that the changes of hepatocytes during shock after histamine liberation are primarily due to the direct influence of released histamine, and secondarily to the influence of hypoxia produced during the shock state.

Animals↗