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Biomedical subjects

A Nordal

Publications and source records attributed to A Nordal.

14 recordsLinked to original sources
PubMed1996

Cytotoxic triterpenoids from the leaves of Euphorbia pulcherrima.

Two cytotoxic triterpenes have been isolated from Euphorbia pulcherrima. Their structures and stereochemistry have been established from NMR, IR, and EI-mass spectroscopy. The compounds were identified as 9,19-cycloart-23-ene-3 beta,25-diol and, 9,19-cycloart-25-ene-3 beta,24-diol. Cytotoxicity evaluation was performed using Ehrlich ascites tumor cells. While cycloartenol induced no cytotoxic activity against Ehrlich ascites tumor cells, both isolated triterpenes exhibited cell inactivating effects. The IC50 is approximately 7.5 microM, while the IC90 is approximately 13.5 microM for 9,19-cycloart-25-ene-3 beta,24-diol. The 3 beta,25-diol compound is 50% less active.

Animals↗
PubMed1992

[Cooperation between regional and central hospitals--how to achieve the best results?].

The authors reviews a recent governmental analysis of cooperation between third-line university clinics and local and central hospitals. The hospitals are owned by the government (mainly by the counties), and the various Acts and regulation permit the central authorities to make decisions on all aspects of highly specialized medicine. The analysis concludes that a limited number of problems should be solved by decision of the central government, but only those where national concerns are involved. The counties within a health region should cooperate within a Regional Health Policy Board, to create plans for flow of patients through the health care system, specified for each field of medicine. When such plans have been approved by the Regional Health Policy Board, each county should be willing to accept them. In the event of local disagreement, the central government should decide.

Health Policy↗
PubMed1992

[Highly specialized medicine. How to assign the tasks?].

Norway has four million inhabitants and five university hospitals, each serving one health region. The authors describe the work of a governmental medical committee, whose mandate is to advise on where to locate the various highly specialized medical services. Important questions have been the relationship between experience and quality, and the desire of each university clinic to be able to provide treatment within its own region for most health problems. Their reasons are concern about research and specialist training, and the preference of patients for treatment near to home. A list of proposed national and over-regional centers for certain treatments has been prepared on the basis of the experts' report and comments from all university clinics. These recommendations have provided a medical basis for later economic and political analyses prior to final decision by the Government. Norwegian legislation permits strong governmental regulation of the highly specialized health services.

Health Planning↗
PubMed1992

Increase in thebaine content of Papaver bracteatum Lindl. after colchicine treatment of seeds. Annual fluctuations in thebaine level of individual plants.

From colchicine-treated seeds of Papaver bracteatum Lindl. some poppy plants were obtained that developed capsules richer in thebaine than the controls. The individual poppies were analyzed for capsule thebaine content annually for eight successive years, the results revealing significant year-to-year differences. One of the poppies, X7, (ca 5% thebaine) developed capsules consisting partly of polyploid tissue during the first and second year. This plant was propagated vegetatively to give a series (the X7 series) of new P. bracteatum plants. The capsule thebaine content of these individuals differed markedly the first two years, whereupon the alkaloid production decreased and appeared to level out and reach a value still clearly higher than the controls (mean values 2.3% and 1.3%, respectively). From seeds of four of the thebaine-rich poppies of the X7 series, four new series of P. bracteatum plants were obtained. The capsule thebaine level of these was significantly lower than that of the mother plants.

Colchicine↗
PubMed1980

Khat: pharmacognostical aspects.

A survey was made of the early literature on the production of khat. A botanical and micromorphological examination of 15 samples of Catha edulis was carried out and the findings were compared with data from the earlier literature on the subject. Based on earlier and present observations, the vital organs (leaves, flowers, fruit and seeds) are described, with illustrations, to assist in the identification of khat.

Catha↗
PubMed1969

Phorbic Acid biosynthesis in the latex vessel system of euphorbia.

Evidence is presented that phorbic acid is formed in the latex producing cell system, rather than in photosynthetic or chlorophyll-free tissues of Euphorbia resinifera Berg. When a branch of the plant was kept first in a (14)CO(2) atmosphere with 12 hr light-dark periods for 2 days and then left under natural conditions in the air outside for at least 2 to 3 days, radioactive phorbic acid was found in the latex. Phorbic acid synthesis appeared to be independent of the photosynthetic and respiratory activities of the plant.Besides phorbic acid 2 other major radioactive compounds were recognized in the latex, a glycoside or oligosaccharide, and a lipid belonging to the group of triterpenoid compounds characteristic of the latex in several species of Euphorbia.

Journal Article↗