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Biomedical subjects

A Notarbartolo

Publications and source records attributed to A Notarbartolo.

At least 127 records · Page 7Linked to original sources
PubMed1984

[Serum monoamine oxidase (MAO) as a prognostic indicator in chronic active hepatitis. II].

Aim of this study was to evaluate the prognostic value of sMAO activity, assayed by benzylamine colorimetric method. Has been studied the correlation between clinical signs of portal hypertension (splenomegaly, ascites and varices) and sMAO levels; there was a significant increase of enzyme activity in chronic active hepatitis (CAH) with splenomegaly vs. CAH without, and in liver cirrhosis (LC) with splenomegaly and/or varices vs. LC without; there was also a correlation between sMAO and gamma-globulins levels in CAH and not in LC patients. In conclusion has been discussed the prognostic value of sMAO activity in CAH.

Colorimetry↗
PubMed1984

[Serum monoamine oxidase (MAO) in the differential diagnosis of chronic liver disease. I].

Aim of this study was to evaluate the diagnostic value of serum MAO activity (sMAO) in chronic liver disease. sMAO has been assayed by benzylamine colorimetric method. No statistically significant differences of sMAO values have been found between controls and acute viral hepatitis or various diseases patients. Differences instead between controls and patients sMAO values (chronic persistent hepatitis, chronic active hepatitis and liver cirrhosis) were statistically significant (p less than 0.005).

Acute Disease↗
PubMed1983

[Glucose compensation, serum lipids and thyroid hormones (rT3 and rT3/T3 ratio in non-insulin-dependent (type 2) diabetics: 2].

In 45 type 2 diabetics it was unable to be found a relation between the plasma lipids and the fasting blood glucose (G), HbA1c, reverse T3 (rT3), rT3/T3 ratio, and relative body weight (R.B.W.). The conclusion was reached that the alteration of the lipoprotein metabolism and the thyroid hormones in type 2 diabetics could be primitive and independent from the availability of the insulin.

Adult↗
PubMed1983

[Glucose compensation, serum lipids and thyroid hormones (rT3 and rT3/T3 ratio) in insulin-dependent (type 1) diabetics: 1].

In 21 type 1 diabetics a significative positive correlation was found between plasma triglycerides (TG) and fasting blood glucose (G), HbA1c, reverse T3 (rT3), rT3/T3 ratio and relative body weight (R.B.W.); total cholesterol (C) and HDL-cholesterol (HDL-C) were not correlated. If you consider the R.B.W. during the correlation between TG and the other laboratory tests, the only correlation that remains significant is that between TG and HbA1c. Plasma hyperTG found in type 1 diabetics appears to depend upon poor diabetic control and overweight; HDL-C is within normal limits because the removal of TG was slightly involved.

Adolescent↗
PubMed1983

Determination of HDL-cholesterol. Comparison between two methods.

We have evaluated a new method for HDL Cholesterol assay, using heparin-CaCl2-NaCl2. This method is in good correlation with PTA-MgCl2 technique. Our results are precise and accurate. HDL Cholesterol mean values: Normolipemic subjects, Cholesterol 190 +/- 13 mg% - Triglycerides 95 +/- 25 mg% - HDL-C 40.99 +/- 8.76 mg%; Ipertrigliceridemic subjects, Cholesterol 235 +/- 20 mg% - Triglcerides 284 +/- 30 mg% - HDL-C 30 +/- 4.7 mg%.

Cholesterol↗
PubMed1982

Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients.

In 13 type II hyperlipidemics (10 males and 3 females; mean age 50.2 +/- 10.6 years), in 10 type IV hyperlipidemics (7 males and 3 females; mean age 51 +/- 13.3 years) and in 23 healthy age- and sex-matched controls, the following parameters were measured: plasma cholesterol; plasma TG; plasma C-HDL; VLDL, separated in a preparative ultracentrifuge; C-LDL; Apo B, with immunoelectrophoretic method; platelet sensitivity to prostacyclin; TXB2 formation in PRP; TXB2 in serum. This study provides evidence for: 1. Reduced platelet sensitivity to prostacyclin, more evident in type II hyperlipidemia that provides an additional mechanism involved in increased platelet aggregation found in type II hyperlipidemia. 2. Enhanced TXB2 formation in PRP after thrombin stimulation (664.65 +/- 142.18 pmol/10(8) platelets) only in type II hyperlipidemics and such enhanced formation was positively correlated to C-LDL (r = 0.53; p less than 0.05) and to Apo B (r = 0.62; p less than 0.05); serum TXB2 formation rate was also increased in type II hyperlipidemia.

Adult↗
PubMed1982

Apo-lipoproteic pattern in type II diabetics (I.I.D.) with macroangiopathy and with no apparent clinico-instrumental signs of microangiopathy.--Note I.

A significant increase of Tg, Tg-VLDL, C, C-VLDL, C-LDL and apo B, a reduction of C-HDL/C ratio and no difference in C-HDL were evidenced in 31 compensated macroangiopathic I.I.D.. No significant differences were noticed dividing the 31 I.I.D. in two groups according to their sex; C-HDL was higher in the females. Our results agree with those of Reckless and Schönfeld. In conclusion we think that an association between macroangiopathy and lipoproteic alteration in compensated I.I.D. can be stated according to our data.

Apolipoproteins↗
PubMed1982

Apo-lipoproteic pattern in type I complicated diabetes (I.D.D.) with microangiopathy and with no clinico-instrumental signs of macroangiopathy.--Note II.

No significant changes of C, C-HDL, C-VLDL, C-LDL, C-HDL/C, Tg, Tg-VLDL and apo B were evidenced in 12 compensated microangiopathic I.D.D. in comparison with 20 healthy controls. Instead the analysis of the data obtained comparing the same I.D.D. with 10 decompensated microangiopathic I.D.D., selected with the same criteria, has pointed out no significant changes between the two groups as regards C, C-HDL, C-VLDL, C-LDL, C-HDL/C and a statistically significant increase of Tg and Tg-VLDL in the 10 decompensated I.D.D.. Our results agree with those of Nikkila and we think we can conclude that it is not possible to evidence a characteristic lipidic or lipoproteic "marker" in compensated microangiopathic I.D.D.

Adult↗
PubMed1982

Thromboxane B2 formation and platelet sensitivity to prostacyclin in insulin-dependent and insulin-independent diabetics.

TxB2 formation in PRP after thrombin stimulus, serum TxB2 and platelet sensitivity to prostacyclin and the correlation with ambient fasting plasma glucose and lipoproteins were determined in 20 insulin-independent diabetics (IID) with macroangiopathy, 10 insulin-dependent diabetics (IDD) with microangiopathy and 30 matched controls. Platelets obtained from insulin-independent diabetics synthetize significantly higher amounts of TxB2 than those of insulin-dependent diabetics and matched controls. IDD and IID patients required significantly higher concentrations of prostacyclin (p less than 0.001) for a similar degree of platelet aggregation inhibition. The amount of prostacyclin required for 50% platelet aggregation inhibition was correlated with fasting plasma glucose (r = 0.64, p less than 0.001) and HbA1% (r = 0.48, p less than 0.01) in all diabetic subjects. We conclude that: 1) only PRP, obtained from some insulin-independent diabetics with a concomitant macroangiopathy, shows an increased synthesis of TxB2; 2) platelet sensitivity to prostacyclin is highly dependent on the fasting ambient plasma glucose.

Adult↗
PubMed1982

Enhanced platelet release reaction in insulin-dependent and insulin-independent diabetic patients.

Plasma beta thromboglobulin (BTG) and platelet factor 4 (PF4) levels were measured and correlated with plasma lipid and lipoprotein patterns in 20 insulin-independent diabetics, in 10 insulin-dependent diabetics and in 30 healthy controls matched to patients as to age, sex and weight. Increased plasma BTG and PF4 levels both in insulin-dependent and in insulin-independent diabetics indicate enhanced in vivo platelet activation and release reaction in these patients. No difference in BTG and PF4 values between these two groups of diabetic patients was observed in our study. A marked correlation between plasma PF4 values and plasma glucose levels was shown in insulin-dependent diabetics only whereas a significant positive correlation with plasma triglycerides and plasma triglyceride VLDL and a negative correlation with cholesterol-HDL was shown in insulin-independent diabetics.

Adult↗
PubMed1981

[Serum lipoprotein fractions in chronic liver diseases with and without alcoholism].

Total serum cholesterol (C) and triglyceride (TG) levels, C and TG-VLDL, C-LDL and C-HDL, total apoprotein B (apo B) and albumin (alb.) have been studied in three groups of patients with liver cirrhosis (CE), persistent hepatitis (EPS) and alcoholic chronic liver disease (EA) divided in two sub-groups of 4 EPS and 4 CE, and have been compared with controls values. In all cases the diagnosis was made on liver biopsy C, C-LDL and C-HDL levels were significantly lower in EPS, C and C-LDL in EA and CE; comparing the three groups each other, the only statistically significant difference was found for C-HDL values, more elevated in the 4 cases of EPS with alcoholism than in CE and EPS without alcoholism.

Adult↗