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Biomedical subjects

A Novick

Publications and source records attributed to A Novick.

At least 37 records · Page 2Linked to original sources
PubMed1992

Healing rates of plantar ulcers in leprosy and diabetes.

Comparison was made of wound healing time in a consecutive series of leprosy and diabetic patients with plantar ulceration. In the leprosy group, 66 of 70 (94%) ulcers healed in a mean time of 42.7 (+/- 36.1) days, and in the diabetic group, 75 of 80 (94%) ulcers healed in a mean time of 39.7 (+/- 32.1) days. Analysis of all healed ulcers using a general linear model found wound depth (p < 0.03), and wound diameter (p < 0.05) significantly related to ulcer healing time. Diagnosis, healing devices (cast, splint and cut-out sandal), age and sex were not significant. In diabetic subjects a regression model including depth, diameter and age explained 36% of the variation in healing time. A meaningful regression model was not found in leprosy patients.

Casts, Surgical↗
PubMed1991

Methods of treating plantar ulcers.

The purpose of this article is to describe the indications, precautions, and fabrication techniques for orthotic devices the authors use to facilitate the healing of plantar ulcers. The methods of fabricating and applying three types of orthotic devices developed by the staff at the Gillis W Long Hansen's Disease Center--walking casts, walking splints, and cutout sandals--are described. Patient examples are given for each of the methods. These techniques, in conjunction with patient education and the use of special footwear, provide clinicians with procedures they can use to aid in the healing of plantar ulcers secondary to leprosy, diabetes, or other neuropathic conditions.

Casts, Surgical↗
PubMed1990

Treatment of acute vascular occlusions with intra-arterial urokinase.

This study reviewed 57 patients with 71 vascular occlusions treated with urokinase from 1985 to 1988. Of these patients, 89% were candidates for urgent surgery. Total clot lysis was achieved in 73% of cases. The success rate rose with increasing experience (p less than 0.05), and recent occlusions had more favorable outcomes than older ones (p less than 0.05). The length and type of occluded conduit (graft or vessel), age, sex, other medical conditions, and concurrent use of heparin had no influence on success. Of 18 cases successfully lysed and not subjected to any adjunctive therapy directed at the cause of occlusion, 9 (50%) reoccluded within 1 to 88 days (mean: 25 days). Cases successfully treated with thrombolysis and surgery or dilation of the causative stenosis had poor 1-year patencies: 17%, 20%, and 55% for vein grafts, prosthetic grafts, and native arteries, respectively. With additional urokinase treatments, surgical operations, and percutaneous procedures, 1-year patencies were 22%, 45%, and 65%, respectively.

Acute Disease↗
PubMed1989

Salvage surgery for renal cell carcinoma.

Complete surgical excision of solitary metastatic lesions in renal cell carcinoma has been reported to be associated with improved survival. An analysis of 65 outpatients undergoing excision of metastatic renal cell carcinoma is reviewed. In our series there was no significant difference among patients with solitary versus those with multiple metastasis. The overall 5-year survival was considerably lower than previously reported. We recommend that only patients with good performance status, who are participating in protocols with biological response modifiers, could potentially benefit from surgical removal of metastatic lesions.

Carcinoma, Renal Cell↗
PubMed1985

Medial agenesis associated with multiple extracranial peripheral and visceral arterial aneurysms.

Developmental abnormalities consisting of focal absence of the arterial media have been implicated in the formation of the arterial aneurysms commonly observed in the intracranial cerebrovascular system. However, this observation has rarely been associated with visceral or peripheral arterial aneurysm formation. This article describes the experience with two patients having multiple peripheral and visceral arterial aneurysms with histologic findings previously observed only in intracranial, saccular berry aneurysms and in one patient with an isolated common carotid artery aneurysm. The two patients described herein had no clinical or angiographic evidence of cerebrovascular aneurysm formation. Light and electron microscopic histologic studies revealed complete focal absence of the arterial media in the region of aneurysm formation. No clinical or laboratory evidence of associated collagen-vascular disease was demonstrated. The patients were successfully managed with segmental resection and grafting of symptomatic, expanding, or large aneurysms. The necessity for an aggressive search for associated aneurysms as well as the need for long-term follow-up when histologic evidence of medial agenesis is demonstrated in association with arterial aneurysm formation are emphasized.

Aneurysm↗
PubMed1985

Quarantine and AIDS.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Renal transplantation of patients on chronic peritoneal dialysis.

A retrospective review of patients transplanted from peritoneal dialysis was performed to assess the risk of this form of dialysis for patients awaiting renal transplantation. Eighteen transplants have been performed in 16 patients, ages 6 to 57 years, undergoing chronic peritoneal dialysis over the past 4 years. Sixteen were from cadaver donors, and two were from living related donors (LRD). The patients had been undergoing intermittent peritoneal dialysis or continuous ambulatory peritoneal dialysis (CAPD) using permanent silastic catheters, from five days to 4 years. No patient had clinical evidence for peritonitis at the time of transplantation. The peritoneal catheter was removed at the time of transplant in all cadaver donor recipients without complication. One recipient of a LRD kidney had the catheter removed two days prior to transplant. Cultures of the catheter were sterile in 16 cases. Two patients had positive peritoneal catheter cultures at the time of transplant but were treated with appropriate antibiotics and never developed clinical peritonitis. Fourteen transplants had postoperative fevers. No definite source was found in 13; one had fever in relation to acute graft rejection. The fevers resolved in all patients either spontaneously or subsequent to therapy. Other complications were similar to those seen in patients transplanted from hemodialysis. Hemodialysis was performed as needed pretransplant and posttransplant using a temporary femoral vein catheter or arteriovenous fistula without complication. Nine patients are alive with a functioning kidney 1 to 36 months posttransplant (mean 17 months). Six transplants rejected (five patients), and one failed secondary to renal vein thrombosis. Two patients died posttransplant, one after a cerebrovascular accident, and one due to an unknown cause 1 month postnephrectomy for rejection. In conclusion, patients undergoing chronic peritoneal dialysis can be successfully transplanted without a significant incidence of complications related to their peritoneal dialysis.

Adolescent↗
PubMed1982

The treatment of sexual phobias: the combined use of antipanic medication and sex therapy.

During the past 20 years, there has been described a group of profoundly anxious and phobic patients, who are not amenable to psychological forms of treatment or to the major and the minor tranquilizers, but who respond dramatically to tricyclic and MAO inhibitor medication. The separation of this drug-responsive syndrome from other anxiety disorders constitutes a major advance in psychiatry. This paper discusses the implications of these findings for the treatment of psychosexual disorders. To illustrate the hypotheses and discussion, the case histories of three patients with sexual phobias are described. All had been treatment failures with sex therapy and psychotherapy but responded to a combination of tricyclic medication and sex therapy which was modified to accommodate the special needs of sexually phobic patients.

Adult↗