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Biomedical subjects

A O Nielsen

Publications and source records attributed to A O Nielsen.

14 recordsLinked to original sources
PubMed1992

[Aluminum allergy caused by DTP vaccine].

All children referred to two private dermatological practices from 1 Jan. 1985 to 31 Dec. 1990 who had pruritus and subcutaneous infiltrates in the areas of immunization with Di-Te-Pol vaccine were patch tested with a Finn Chamber or with 2% aqueous aluminium chloride. Di-Te-Pol vaccine contains aluminium hydroxide. Contact allergy to aluminium was demonstrated in 32 children (20 girls and 12 boys). Of the three patch test methods used, testing with 2% AlCl3 occluded with a Finn Chamber proved to be the most sensitive. Immunization of children who have been shown to be allergic to aluminium should be carried out with vaccines which do not contain aluminium.

Aluminum↗
PubMed1992

Vaccination granulomas and aluminium allergy: course and prognostic factors.

21 children who had cutaneous granulomas following immunization with a vaccine containing aluminium hydroxide, and who had positive patch tests to aqueous aluminium chloride and/or to a Finn Chamber, were followed for 1 to 8 years. During the period of observation, the symptoms cleared in 5 children, improved in 11, and remained unchanged in 5. The course of the granulomas could not be correlated with sex or atopy, nor with intensity of the initial aluminium patch test. 4 children were patch tested again with aluminium.

Adolescent↗
PubMed1991

Topical metronidazole in the treatment of perioral dermatitis.

The twice-daily topical application of 1% metroindazole cream was compared with 250 mg oral tetracycline, taken twice daily, in the treatment of perioral dermatitis in a prospective, double-blind, double-dummy, randomized, multicenter trial. One hundred eight patients were treated for 8 weeks. At the end of this time the median number of papules in the metronidazole-treated group was reduced to 8% of the initial number, and the median number in the group treated with tetracycline was reduced to 0% of the initial number. Although both treatments were effective, oral tetracycline was significantly more effective than topical metronidazole.

Administration, Cutaneous↗
PubMed1991

Treatment of lichen planus with acitretin. A double-blind, placebo-controlled study in 65 patients.

Sixty-five patients with lichen planus were included in a multicenter trial of acitretin. At the end of an 8-week placebo-controlled, double-blind phase, a significantly higher number of patients treated with 30 mg/day acitretin (64%) showed remission or marked improvement compared with placebo (13%). Furthermore, during the subsequent 8-week open phase, 83% of previously placebo-treated patients responded favorably to acitretin therapy. Typical retinoid adverse reactions were present in all patients on active drug. Laboratory studies did not show any clinically significant changes. This study shows that acitretin is an effective and acceptable therapy for severe cases of lichen planus.

Acitretin↗
PubMed1979

Dermatomyositis with universal calcinosis. A histopathological and electron optic study.

Biopsies from a 5-year-old girl with dermatomyositis and universal calcinosis were studied histopathologically and by means of electron optical techniques. The dermis was infiltrated by fibroblasts, lymphocytes and plasma cells. In the lower part of the dermis, dense basophilic areas were present. In the vicinity of these areas irregular elastic fibers appeared. In the electron microscope these elastic fibers appeared mineralized to varying degrees. The mineral part was identified as calcium apatite (either calcium-hydroxy-apatite or calcium fluoroapatite) by X-ray microanalysis and selected area diffraction. No calcification was observed outside the elastic fibers.

Calcinosis↗
PubMed1978

Salpeter-induced dermal changes electron-microscopically indistinguishable from pseudoxanthoma elasticum.

Salpeter-induced calcium deposits in ten patients showed a close clinical and histopathological similarity to the lesions of pseudoxanthoma elasticum. By electron microscopy and selected area diffraction analyses of the calcium deposits we find the changes indistinguishable from the changes previously described in involved skin of patients suffering from PXE. Clinically our patients were compared with the fourteen patients with traumatic calcification previously described.

Aged↗
PubMed1978

Pediculosis capitis treated with quassia tincture.

454 patients were treated with quassia tincture for head lice. At examination one week later only three patients had hatched lice. There was firm evidence that these patients had been reinfested. The treatment procedure was acceptable both to patients and to staff and no side-effects were observed. As resistance to clophenothane has appeared, alternative cures are needed. This study confirms earlier reports on the effectiveness of quassia tincture, which seems to be a useful alternative to clophenothane. At present the recommended treatment is two applications with an interval of one week.

Chemical Phenomena↗
PubMed1976

Gonorrhoea in patients with scabies.

242 patients with scabies were examined for gonorrhoea at the Municipal Hospital of Copenhagen over a one-year period. We found asymptomatic gonorrhoea in 2% of the male patients and 12%. of the female patients. The incidence of gonorrhoea in female patients with scabies is thus higher than in other routinely examined groups of patients (Andersen and Nielsen, 1974; Gregersen, 1972; Hansen and Lange, 1973; Nielsen, 1974; Starck, Bygdeman, Eriksson, Heinerz, and Moberg, )971). Our suggestion is that all patients with scabies, male as well as female, should be examined routinely for gonorrhoea.

Adolescent↗
PubMedDate not supplied

An evaluation of microcult g.c. in venereal disease clinics.

Microcult G.C. is a kit for cultivation and identification of Neisseria gonorrhoeae. ue of this kit was compared with the cultivation and identification methods of the Neisseria Department, Statens Seruminstitut, Copenhagen (WHO collaborating center for reference and research in gonococci). The investigation included 203 men and 80 women who appeared for examination at our veneral disease clinics. For examination of urethral specimens from men the predictive value of positive tests was found to be 93% and the predictive value of negative tests was 94%. For specimens from the urethra and cervix of women, the predictive value of positive tests was 95% and the predictive value of negative tests was 90%. The reliability of these results makes Microocult G.C. a valuable supplement to microscopy in venereal disease clinics with a relative high prevalence of gonorrhoea. The predictive value of positive tests from the anal canal was 21% and from the tonsils 3%; in these locations the test is not suitable for diagnostic purposes.

Anus Diseases↗