PubMed Health⌕ Search

Biomedical subjects

A O Ogunmekan

Publications and source records attributed to A O Ogunmekan.

At least 19 recordsLinked to original sources
PubMed1989

Sturge-Weber-Dimitri disease: role of hemispherectomy in prognosis.

We report 12 patients with Sturge-Weber-Dimitri disease treated surgically between January 1975 and December 1987. Hemispherectomy was performed on ten, two others underwent occipital lobectomy for intractable seizures. All operations were performed between the ages of 3 months and 20 months, except in two at age 8 and 9 years. The onset of seizures in all was between 2 and 8 months of age, except for two at 15 months. There were no postoperative deaths. Postoperative shunt procedures were required in 3 out of 12 (25%). Postoperative seizure control for one year or more was achieved in 11 out of 12 patients. The remaining patient is on medication with no seizures, but follow-up is less than a year. Intellectual deterioration was not seen after surgery except in 2 patients who had late operations. We conclude that patients with Sturge-Weber-Dimitri syndrome who have intractable seizures in the first 6 months of life and unilateral hemispheric involvement should be considered for early resection of the involved hemisphere.

Angiomatosis↗
PubMed1989

Enuresis in sickle cell disease. I. Prevalence studies.

The prevalence of enuresis was determined by parental interview in Nigerian children with sickle cell anaemia and in age-matched controls without sickle haemoglobinopathy. There were a total of 209 subjects with sickle cell anaemia (SCA) in steady state and 200 controls of both sexes aged from 2 to 20 years. The prevalence of enuresis was 41.6 per cent in those with SCA and 18.5 per cent in the controls. In subjects who were 4 years or more the prevalences were 36.8 and 21 per cent, respectively. These differences were highly significant (P less than 0.001). There was a significant preponderance of males among enuretic control subjects (2.6 to 1) who were aged 4 years or more (P less than 0.05) which was not apparent in the sickle cell subjects at any age or in the controls below the age of 4 years.

Adolescent↗
PubMed1985

Plasma vitamin E (alpha tocopherol) levels in normal children and in epileptic children with and without anticonvulsant drug therapy.

Plasma alpha tocopherol was assayed in 308 apparently normal children, epileptic children not on anticonvulsants, and anticonvulsant-treated epileptic children. The age range of the subjects was 5 to 12 years and both sexes were equally represented in each group. Plasma alpha tocopherol levels were significantly (p less than 0.001) lower in the anticonvulsant-treated epileptic children than either of the other groups. The values in all groups were lower than published values for adults. No difference in plasma alpha tocopherol values was attributable to sex. The lower plasma alpha tocopherol value in the anticonvulsant-treated epileptic children is probably related to the drug therapy.

Anticonvulsants↗
PubMed1979

Vitamin E deficiency and seizures in animals and man.

Study of 100 children with grand mal convulsive disorders and 100 medically healthy children of matching age showed significantly lower plasma levels of vitamin E in the former (means 632.2 +/- 17.3 and 822.5 +/- 21.8 micrograms/dl respectively; p less than 0.001). This finding accords with the ability to prevent seizures in rodents by giving alpha-tocopherol before exposing them to a convulsion-inducing environment.

Animals↗
PubMed1979

Relationship between age and vitamin E level in epileptic and normal children.

Plasma vitamin E was assayed in 100 children on anticonvulsants either singly or in combination. Their plasma vitamin E levels were lower than in 100 apparently normal children. The age range of the children was between 2 and 12 years. The plasma vitamin E levels of the control children were lower than published values for adults. In the normal course of development, vitamin E levels increase with age but this developmental pattern does not occur in groups of epileptic children, and this may be related to the metabolic effects of drug therapy in epilepsy.

Aging↗
PubMed1979

Predicting serum vitamin E concentrations from the age of normal and anticonvulsant drug-treated epileptic children using regression equations.

Serum vitamin E was assayed in 100 patients who were apparently normal, with no medical problems and on no medication, and whose ages ranged from 2 to 12 years. Serum vitamin E was also assayed in 100 patients with grand mal convulsive disorders, on anticonvulsants, but on no other drugs, with no gastrointestinal problems and in a similar age range. In the 100 control children, there was a tendency for serum vitamin E to increase with age. Serum vitamin E concentrations in 100 anticonvulsant drug-treated epileptic children were significantly lower than in the control group and did not increase with age. In the control group, a regression analysis was used to predict serum vitamin E concentrations in different age groups. This information would be useful for population and metabolic studies of serum vitamin E concentrations.

Age Factors↗
PubMed1978

Infantile cortical hyperostosis (Caffey's disease).

A case of infantile cortical hyperostosis (Caffey's disease) is presented with its usual clinical and radiological manifestations. The accompanying anaemia and thrombocytopenia as seen in our case is discussed. The possibility of autoantibodies secondary to an immunological defect is put forward to explain the cause of the anaemia and thrombocytopenia. This may be a new feature of the disease or a modification of the current concept.

Anemia↗