Allelic exclusion model questioned.
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Biomedical subjects
Publications and source records attributed to A Oancea.
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Cicatrisant collagen compress are biomaterials performed from type I collagen purified. Experimental studies including trials carried out in vitro and in vivo, demonstrated the biocompatibility of these biomaterials and their effect on accelerating the process of dermic wound re-epithelization. A subsequent stage of our investigations consisted in clinical trial of these cicatrisant compresses. These were applied to post-traumatismal wounds of variable areas or to 2nd and 3rd degree of deeper burns. The obtained results demonstrated that collagen biomaterials as cicatrizing compresses are well tolerated by human organism, they do not cause inflammations, necroses or other undesirable phenomena at the site of application. Also it was found that these biomaterials are not antigenic, since anticollagen type I antibodies were not present in nome of the treated patients' serum and accelerate the epitelization.
One of the efficient possibilities for regaining the anal continence consists of using the pediculated gracilis muscular flap. The electrostimulation of the anal neosphincter and the functional rehabilitation are of major importance in obtaining a good result. The present paper is based on 5 cases in which this method was applied.
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