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Biomedical subjects

A Oigaard

Publications and source records attributed to A Oigaard.

At least 19 recordsLinked to original sources
PubMed1978

Electrical spike activity in the human small intestine. A multiple electrode study of fasting diurnal variations.

An intraluminal probe with 10 pairs of bipolar electrodes was used for continuous recording of myoelectric activity along the entire small intestine during 24 hr in 2 normal fasting human subjects. Two types of regular migrating activity were observed: (1) Bands of a great number of spike potentials appearing at hourly intervals migrating through the entire small intestine. This activity corresponds to phase III of the "interdigestive myoelectric complex" described in animal experiments. (2) Bursts of a few spike potentials appearing with minute intervals migrating only through the jejunum. This activity has not previously been demonstrated in man nor in intact animals, but corresponds to the "minute-rhythm" described from in vitro experiments.

Action Potentials↗
PubMed1977

Effects of cholecystokinin on the motility of the distal duodenum and the proximal jujunum in man.

Electrical spike potentials and intraluminal pressure variations were recorded in the distal part of the duodenum and proximal part of the jejunum in 5 normal human subjects before and after a bolus injection of cholecystokinin. A considerable increase in activity was observed in the jejunum after the hormone, whereas there was no response in the distal duodenum. Absence of reaction in the proximal duodenum and an increase in the motility in the distal ileum has previously been demonstrated after cholecystokinin administration. It is concluded that the human duodenum differs from the rest of the small intestine in its reaction to cholecystokinin. The change in reaction appears to occur on a level with the ligament of Treitz.

Cholecystokinin↗
PubMed1976

Electrical spike potentials of the small bowel: a comparative study of recordings obtained from muscular implanted and intraluminal suction electrodes.

Electrical spike potentials from the canine duodenum have been recorded from intramuscular implanted and intraluminal suction electrodes. There was a significantly greater amplitude of the spike potentials recorded from implanted electrodes, otherwise the potentials were identical in number, duration and time of onset. Thus spike potentials recorded from suction electrodes, as used in clinical motility studies, accurately represent the event within the muscular layer.

Action Potentials↗
PubMed1976

Embolization to the superior mesenteric artery. Arteriography and embolectomy in four cases.

Four patients were operated upon for embolization to the superior mesenteric artery. Preoperative arteriography was performed in all cases. Two patients who had had symptoms prior to operation for six and eight days respectively died postoperatively. One patient died 2 1/2 months after the operation from her underlying heart disease, while one patient was discharged with intact bowel function. The value of preoperative arteriography and the principles for surgical treatment are discussed.

Aged↗
PubMed1975

The narrow vestibular aquaeduct. An unspecific radiological sign?

Tomography of the vestibular aquaeduct was carried out in patients with Ménière's disease, patients with chronic otitis and in patients without ear disorders. Visualization of the vestibular aquaeduct was evaluated blindly. The descending part of the aquaeduct was clearly visible in 95% of patients without ear disease. In the other groups, including contralateral non-affected ears in Ménière patients, the aquaeduct was clearly visible in only about 50%. The incidence of narrow or invisible aquaeducts in ducts in Ménière patients and in patients with chronic otitis was essentially the same. This radiologic finding seems to be an unspecific sign, present possibly in a variety of ear disorders.

Adolescent↗
PubMed1975

Renal distension in response to water-soluble contrast medium and various diuretics.

Measurement of the increase in area of the renal silhouette, as it appears on radiographs following the administration of water-soluble contrast medium and certain diuretics, seems to be useful in the diagnosis of renovascular hypertension. In order to assess the optimal technique for such measurements, washout urography was performed in 32 hypertensive patients in two consecutive examinations so that the distensive effect of etacrynic acid, furosemide and hypertonic mannitol, respectively, were compared with that of urea in the same patients. In spite of their stronger diuretic effect, none of the above-mentioned diuretics caused a greater renal distension than urea, the maximum increase in area of the renal silhouette being about 7 to 20%, average about 11%. Since urea is probably the best siuted diuretic for the washout test, it seems to be the drug of choice for these diagnostic procedures.

Adult↗
PubMed1975

The motor-stimulating effect of metoclopramide and pyridostigemine bromide in normal man and laparotomized patients. A combined study of duodenal electric and motor activity.

The effect of metoclopramide on duodenal motility was compared to that of pyridostigmine bromide by means of stimulaneous recordings of electrical action potentials (spike potentials) and intraluminal pressure variations in 40 normal young volunteers and 8 patients after intraperitoneal operations. Quantitative calculations according to a previously described system showed a significant increase in activity in the normal material after both drugs. The increase was greatest after metoclopramide and appeared more rapidly. Compared with the normal individuals, patients in the postoperative phase showed a moderately decreased activity before drug administration. No significant increase in activity could be demonstrated after either of the drugs.

Adolescent↗
PubMed1975

The effect of cholecystokinin on electrical spike potentials and intraluminal pressure variations in the human small intestine.

Electrical spike potentials and intrauminal pressure variations were recorded from the human duodenum and distal ileum before and after i.v. administration of 80 log Ivy units of cholecystokinin. In the duodenum, quantitative calculations of motility gave identical values before and after drug administration, and results were identical in patients before and after cholecystectomy as well as in hernia patients without upper gastrointestinal disease. A decrease in amplitude of the spike potentials was observed in the duodenum during the first few minutes after drug administration in all groups. Recordings from the distal ileum in ileostomy patients showed a significant increase in motility after CCK administration whereas the spike potential amplitude was unchanged.

Action Potentials↗