PubMed Health⌕ Search

Biomedical subjects

A Oliveros Juste

Publications and source records attributed to A Oliveros Juste.

11 recordsLinked to original sources
PubMed2003

[Neurological involvement in systemic sclerosis].

INTRODUCTION: Systemic sclerosis (SS) is recognized as the connective tissue disease which less frequently presents neurological complications; in recent studies it is demonstrated, however, that neurological involvement in SS is more frequent of what it had been assumed. PATIENTS AND METHODS: Clinical neurological exploration was done in 26 patients with definitive SS; an electroneurogram was carried out in 23 cases in order to determine the prevalence of central neurological pathology and of peripheral neuropathy, to define its characteristics, and to investigate possible associations with clinical parameters and with autoimmunity. RESULTS: 23 cases (88%) were females and 3 cases (12%) males; the median age was 57.5 12.0 (SD) years, while the median age to the diagnosis was 51.3 12.3 (SD) years and the median period of natural history of disease was 6.2 3.1 years. Seven patients (26.9%) showed involvement of the CNS, being the headache and the neuropsychiatric manifestations the most common conditions (11.5%). Peripheral neuropathy prevalence was 39.1% (9 cases); according to the distribution of the injury, the polyneuropathy prevailed in 30.4% of cases. With regard to the functional selectivity, the sensitive-motor forms were most frequent (55.6%); according to the most involved structure, the axonal neuropathy was most common (44.4%).Discussion. The possible pathogenic mechanisms of the neurological pathology in this disease are discussed.

Adult↗
PubMed1997

[Prognosis in status epilepticus].

Status epilepticus (SE), an special epileptic syndrome, is a frequent neurological emergency (50/100,000) and a critical condition (mean mortality 22%, in 3% of pediatric patients and 38% in the elderly). Accepting its widest concept, it appears without history of epilepsy in 58%. Neuronal damage, mainly hypocampal, has been experimentally demonstrated in convulsive and nonconvulsive SE. We attempt to demonstrate that the most important prognostic factors are: age, more related to morbidity in children and in mortality in the elderly; etiology, determining the evolution in most cases, but not always: in the same etiological group, the coincidence of SE can increase threefold the mortality; the seizure type, especially the convulsive SE; patients with previous epilepsy have a better outcome; the epileptic syndrome, rather determinant of incidence and outcome of the SE in the childhood; the length of SE, but in the cases of outcome directly depending on the etiology; the evolutive phase in which treatment is started; the complications, mainly respiratory; the global therapeutical strategy and the adequate use of drugs, related to order, dosage and timing, are determinant of morbidity and mortality.

Adolescent↗
PubMed1996

[Quality of life in epilepsy].

Quality of life scales present scoring and response quantification problems when applied to epileptics patients. Moreover, to date they have been based on subjective concepts. Factors related to disease, on the other hand, can give rise to inconsistencies in the objective quality of life. We propose a new scale called the Global Assessment Sheet for Epilepsy in the Adult developed by the Epilepsy Study Group of the Spanish Neurological Society. On a single sheet, whether scored by computer or on paper, the scale attempts to give a clear reflection of clinical picture and course of disease. The data come from multiple sources, homogeneous scores are given for a variety of items and the components are modular such that scores can be used together or separately. The scale represents an effort to provide an objective, concrete scoring system, associating definitions to each score and avoiding responses such as "a lot/normal/little/very little". The scale is physician-assessed so that the questionnaire can be superimposed on well-recorded follow-up medical histories within a reasonable amount of time. New concepts are introduced, such as a crisis index, divided into four main notions: severity of crises, negative impact of side effects, quality of life indicators and self-evaluation of quality of life.

Brain↗
PubMed1994

[The development of epilepsy during fetal gestation: a prospective study of 45 women].

We observed a clinical deterioration of epilepsy observed during pregnancy in 29% of 45 consecutive epileptic women. Increase in frequency of attacks is not related to type of attack, previous frequency, type of epilepsy, age at first appearance, family history or presence of anomalies by computed tomography imaging. No association has been found between recurrence of attacks and maintenance of sub-therapeutic plasma levels of anti-epileptic drugs (AED). In 60% of the patients who deteriorate, there is a temporal relation between increase in attacks and the suspension of or reduction of AED doses. Changes observed during one pregnancy cannot always predict what will happen during subsequent pregnancies.

Adolescent↗
PubMedDate not supplied

[Evolution of epilepsy in successive pregnancies].

INTRODUCTION: Hormonal and metabolic factors related to pregnancy itself are considered to increase the likelihood of seizure recurrence. If so, we should expect a similar evolution of epilepsy in a subsequent pregnancy. We investigated differences in evolution of non-gestational epilepsy in each pregnancy of women suffering from epilepsy. METHODS: A prospective study was conducted in order to compare seizure frequency in two successive pregnancies of more than 36 weeks duration in 12 patients. Improvement/worsening is defined as a change of +/- 50 % in the number of seizures regarding that which occurred within the previous eleven months. RESULTS: Twelve epileptic women were studied during two subsequent pregnancies. Eight of them took the same antiepileptic treatment for both pregnancies and one took no antiepileptic drug. Three worsened in the first pregnancy and two in the second. Seven patients had the same seizure frequency during both pregnancies. The total plasma antiepileptic concentrations tended to decline with the same proportion in both pregnancies if the dose remained unchanged. We observed no differences in mean hormone plasma concentrations for each quarter, within subsequent pregnancies. CONCLUSION: Except for one case with drug-resistant epilepsy, we found that the reason for the discrepancy in the frequency of the seizure between two successive pregnancies in the same patient was a sharp or rapid change in antiepileptic drug dose or non-compliance. In well controlled epileptic women a consistent evolution of epilepsy should be expected in a subsequent pregnancy, if adequate treatment is maintained.

Adult↗