PubMed Health⌕ Search

Biomedical subjects

A Olsson

Publications and source records attributed to A Olsson.

At least 19 recordsLinked to original sources
PubMed1992

Plasma homocysteine in women on oral oestrogen-containing contraceptives and in men with oestrogen-treated prostatic carcinoma.

The mechanism by which oral oestrogen-containing contraceptives in women and oestrogen treatment of prostatic carcinoma in men increases the risk of vascular disease is unclear. These agents decrease serum concentrations of vitamin B12, pyridoxal 5-phosphate, and folate, all of which are essential for the metabolism of the atherogenic amino acid homocysteine. We found serum vitamin B12 concentrations to be lower in 17 women using oral contraceptives (219 +/- 84 pmol l-1) than in 13 age-matched female controls (385 +/- 129, p less than 0.001), but similar values were obtained in the two groups both for fasting plasma homocysteine concentrations (9.1 +/- 2.4 vs 9.2 +/- 3.6 mumol l-1) and for the increase in these concentrations after methionine loading (19.2 +/- 7.5 vs 17.8 +/- 5.2 mumol l-1). In five men with prostatic carcinoma, high-dose oestrogen treatment decreased serum vitamin B12 concentrations by a mean of 30% (p less than 0.05) within 4 weeks, during which fasting plasma homocysteine concentrations decreased (13.8 +/- 4.5 vs 10.5 +/- 2.8 mumol l-1) and response to methionine loading increased (12.4 +/- 3.4 vs 17.3 +/- 5.1 mumol l-1), though the latter changes were non-significant. Our findings do not support the hypothesis that hyperhomocysteinemia explains cardiovascular risk in women using oral oestrogen-containing contraceptives, or in oestrogen-treated men with prostatic carcinoma.

Adolescent↗
PubMed1992

Caregivers' experience of providing care for demented persons living at home.

Caregivers providing home-care for demented persons answered a questionnaire concerning what was satisfactory or problematic when providing home-care. They were also asked what needs/wishes they had for themselves and for the demented persons. The findings reflected the impact of a functioning interpersonal relationship between the caregiver and the demented person and his family. The difficulties in handling problematic behaviour, and the necessity to be able to stimulate and provide activities for the demented were also emphasized. Moreover, the caregivers stressed their role as supporters of the patients' families, their need for more and better cooperation with the staff of the psychogeriatric clinic, and their need for training and supervision in how to manage their relationship with the demented person. Hence, it seems urgent to try to practise and evaluate systematic clinical guidance to provide knowledge and systematic supervision about how to manage demented persons in their own social context so that they can stay in their homes.

Adolescent↗
PubMed1991

Liquid chromatographic determination of the enantiomers of ibuprofen in plasma using a chiral AGP column.

A reversed-phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen. The enantiomers and the internal standard 4-pentylphenylacetic acid are extracted from plasma, separated and quantified on a Chiral-AGP column using ultraviolet detection. The simplicity, sensitivity and precision of the method makes it convenient for use in pharmacokinetic studies.

Animals↗
PubMed1990

The specificity and cellular origin of phenylethanolamine N-methyltransferase (PNMT)-like immunoreactivity in psoriatic skin.

Phenylethanolamine N-methyltransferase (PNMT)-like immunoreactivity has been found in psoriatic skin and in this study, PNMT-like immunoreactivity was investigated in the involved and uninvolved skin of six patients with lichen planus and four patients with lichen simplex. No PNMT immunoreactivity was observed in these diseases. Studies were carried out using cultured fibroblasts from two patients with psoriasis from uninvolved and involved areas of skin and from two controls using antibodies to PNMT, as well as antibodies to the chemical messengers somatostatin, substance P, parathyroid hormone and peptide histidine isoleucine amide. No immunoreactivity to these substances was found, and fibroblasts are unlikely to be the cellular origin of the PNMT-like immunoreactivity as seen in psoriatic skin.

Adolescent↗
PubMed1990

CD8+ T lymphocyte subset in giant cell arteritis and related disorders.

Median percentage and number of circulating CD8+ T lymphocytes (suppressor/cytotoxic T lymphocytes) are markedly decreased in patients with giant cell arteritis (GCA). We assessed the diagnostic usefulness of CD8+ T cell values, in 108 patients who had a temporal artery biopsy during a 3 year period. Histologic evidence of GCA was found in 26 patients. Negative biopsy patients were divided into 2 groups, one with 49 patients and a probable GCA syndrome (polymyalgia rheumatica with a negative biopsy) and a group with non-GCA (33 patients). Median percentage and number of CD8+ T cells were significantly decreased with definite GCA (CD8+% 10.0, CD8+ cells 0.221 x 10(9)/l), and probable GCA syndrome (CD8+% 10.0, CD8+ cells 0.197 x 10(9)/l) compared with non-GCA (CD8+% 22.0, CD8+ cells 0.527 x 10(9)/l) and controls (CD8% 21, CD8+ cells 0.518 x 10(9)/l). Significantly low CD8+ T cell values were found in nearly 80% of patients with active untreated GCA or GCA syndrome and in 15% of patients with non-GCA. Positive predictive value of a significant low CD8+ T cell value is 85% while the likelihood of no GCA or GCA syndrome with normal CD8+ T cell values is 60%.

Biopsy↗
PubMed1975

Effect of quinidine on maintaining sinus rhythm after conversion of atrial fibrillation or flutter. A multicentre study from Stockholm.

In a controlled study comprising 176 patients, quinidine in the form of Kinidin Durules was found to reduced significantly the recurrence of the atrial fibrillation during a 1-year follow-up period after successful electric shock conversion. After one year, 51 per cent (52/101) of the patients in the quinidine group, and 28 per cent (21/75) in the control group remained in sinus rhythm (P smaller than 0.001). No less than 43 per cent of the patients converted to sinus rhythm during treatment with maintenance doses of quinidine sulphate before intended DC conversion. Gastrointestinal side-effects were not uncommon, and caused interruption of quinidine treatment in some cases.

Adult↗