Biomedical subjects

A Ophir

Publications and source records attributed to A Ophir.

41 records · Page 3Linked to original sources

PubMed1977

Cervical incompetence: diagnostic and therapeutic aspects.

During a seven-year period, 311 women with cervical incompetence were treated by cerclage. Fifty-three of the women were treated twice during the study period, 12, three times, and one, four times, so that a total of 391 pregnancies was studied. There were only 45 emergency procedures. Candidates for elective cerclage were selected on the basis of hysterographic findings and the Hegar test. Cerclage was performed by the simple McDonald procedure, usually during the 11th to 12th week of gestation, after the presence of fetal life had been established by ultrasonic detection of the fetal heartbeats. Apart from antibiotics no medical treatment was given. Hospitalization following cerclage was reduced to less than 24 h. The fetal salvage rate was 89%, with minor differences among four etiologic subgroups. The minimum benefit rate of the operations was 64.6%. The degree of cervical patency, as established by the Hegar test, was found to be of prognostic value in cerclage-treated pregnancies. Ultrasonic detection of fetal heartbeat before cerclage significantly improved fetal salvage by almost complete elimination of early fetal loss. Simplification of the surgical procedure is recommended.

Abortion, Spontaneous↗

PubMedDate not supplied

Surgical outcome after early intraocular pressure elevation following combined cataract extraction and trabeculectomy.

BACKGROUND AND OBJECTIVES: We report on the incidence and course of early postoperative intraocular pressure (IOP) elevation and related surgical outcome following combined manual extracapsular cataract extraction (ECCE), using a sclerocorneal tunnel incision and trabeculectomy. PATIENTS AND METHODS: The combined procedure was the initial surgery in each eye. Intraocular pressure was measured during the first 4 days, at 1 week, and thereafter following surgery. RESULTS: Of 38 eyes (38 consecutive adults), postoperative IOP elevation to > 25 mm Hg was found in 7 eyes (18.4%) during the first 3 postoperative days. The IOP was reduced to < or = 20 mm Hg without hypotensive medication in 3 of them within the first 3-7 postoperative days, and remained so after 7-16 months (mean, 10.3 +/- 4.9 months). Each of the other 4 eyes underwent argon-laser suture lysis 8-10 days after surgery due to unstable IOP which rose to > 30 mm Hg. Two weeks after the operation and thereafter, ie, after 8-22 months (mean, 12.8 +/- 6.4 months), each of these 4 eyes necessitated 1-4 (mean, 2.5 +/- 1.3) hypotensive medications. CONCLUSION: This study raises the possibility that in eyes with early IOP elevation, a delay in promoting aqueous outflow beyond a critical period during the first postoperative week might become a risk factor for full surgical success.

Aged↗

PubMedDate not supplied

Needling with intra-bleb 5 fluorouracil for intractable neovascular glaucoma.

BACKGROUND AND OBJECTIVE: Trabeculectomy for neovascular glaucoma (NVG) often results in filtering bleb scarring. The outcome of a needling procedure with intra-bleb 5-fluorouracil (5-FU) administration in NVG eyes is presented. PATIENTS AND METHODS: Following trabeculectomy with mitomycin C (MMC), intraocular pressures (IOPs) ranged between 36 to 56 mm Hg in 3 painful, neovascular glaucomatous eyes despite treatment. Each eye was then injected subconjunctivally with 1.0 mg of 5-FU, adjacent to and within the filtering bleb. The needle was advanced and penetration into the anterior chamber through the bled, anterior to the scleral flap, followed. RESULTS: In each eye, the IOP dropped immediately. After 18 to 29 months, IOPs were 11 to 22 mm Hg, and in two eyes-without hypotensive medications. Cataract progression was evident in the 2 eyes that had had cataracts preoperatively. CONCLUSION: The postoperative needling, in conjunction with the dual effect of intraoperative MMC and intra-bleb 5-FU, was found efficacious and saved further surgery in these intractable cases.

Aged↗

PubMedDate not supplied

Quantitative analysis of hydroxyl radicals in the anterior optic nerve of the cat following transient ischemia.

PURPOSE: Ischemic insults in the optic nerve are relatively common ocular disorders. This study provides quantitative data on the generation of hydroxyl radicals in the anterior optic nerve of the cat during the early reperfusion phase following 90 minutes of ischemia. MATERIALS AND METHODS: Cats were injected intravenously with sodium salicylate that by acting as an hydroxyl radical trap, forms 2,3-dihydroxybenzoic acid (2,3-DHBA). Ischemia was achieved by intraocular pressure (IOP) elevation via cannulation of the anterior chamber. Ischemia was maintained for 60 minutes in 6 eyes and 90 minutes in 12 eyes, followed by 5 minutes of reperfusion. In an additional 6 eyes, ischemia was maintained for 90 minutes without reperfusion. RESULTS: After 90 minutes of ischemia and reperfusion, mean normalized levels of 2,3-DHBA (ie, ng 2,3-DHBA/microg salicylate/mg protein) that represent the levels of hydroxyl radicals were 2.47 times (at least) higher in the anterior optic nerves than in the fellow sham-operated controls (P = 0.03). These levels were 3.9 times (at least) greater than in the corresponding levels after 90 minutes of ischemia without reperfusion (P= 0.005). CONCLUSION: This study provides a quantitative analysis and evidence for the generation of hydroxyl radicals in the optic nerve of the cat following transient ischemia. A quantitative analysis may provide an important tool to detect even relatively small levels of free radicals in the tissues, and to evaluate the relative efficacy of various therapeutic agents in the inhibition of free radical generation following ischemia and reperfusion.

Animals↗

PubMedDate not supplied

Hollow bandage contact lens.

OBJECTIVE: To report on the use of a new bandage contact lens (BCL) for a leaking filtering bleb. PATIENTS AND METHODS: A hollow BCL, with an internal central opening of 6 mm, has been applied on three eyes that had leaking blebs shortly after either trabeculectomy or combined cataract extraction and trabeculectomy, each with a fornix-based conjunctival flap. RESULTS: The treatment with this lens was found beneficial: the leakage subsided and the patients were comfortable with the lens. The internal hollow of the BCL enabled us to monitor the intraocular pressure throughout the entire follow-up period without transient and repeated removal of the BCL. CONCLUSION: The new hollow BCL was found efficacious. The study suggests that this lens may have advantages over the commonly used BCLs that are related to the elimination of the need for its frequent removal and reinsertion for tonometry. This decreases the risk of both the exposure of the lens and the filtering bleb to contamination and the interference with the continuity of the process of conjunctival epithelial closure.

Aged↗