Biomedical subjects

A Oproiu

Publications and source records attributed to A Oproiu.

At least 19 recordsLinked to original sources

PubMed1999

Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association?

Familial adenomatous polyposis (FAP) can be considered as a condition of the whole body as extracolonic features derived from all the three embryonic lineages are recorded with varying frequency in addition to the presence of multiple adenomas in the large intestine. Here, we describe two unrelated cases of FAP with unusual extracolonic phenotypes, namely several abnormalities of mesodermal origin strongly resembling Marfan syndrome (MFS) or a Marfan-like habitus. Conventional cytogenetic and FISH analysis did not reveal any gross chromosomal rearrangement on the long arm of chromosome 5 where the APC and FBN2 genes were located. However, in case 2 the FAP-causing mutation in the APC gene was found in the donor splice site of exon 4 and was shown to result in a frameshift and a premature termination codon. We propose that such connective tissue abnormalities may result from germline APC mutations in combination with specific genetic and/or environmental modifying factors.

Adenomatous Polyposis Coli↗

PubMed1991

[The balloon dilatation of esophageal stenoses].

A number of 55 balloon dilatations were performed on 23 patients with oesophageal stenoses of various aetiologies. Among these, 22 displayed benign stenoses and only 1 case had a malignant aetiology. The number of dilatations per patient varied from 1 to 3. In the evaluation of the results, only the clinical criterion was taken into account, the radiological examination and the oesophageal passage scintigram being inconclusive in the respect. The balloon dilatation was successfully performed in 96% of patients. In the long-term follow-up, 82.4% of the patients with benign stenoses benefitted from this therapeutic procedure. In some patients it was necessary to repeat dilatation. The asymptomatic free interval was on the average of 11.5 months. It is concluded that the balloon dilatation is a simple, safe and readily applicable therapeutic method, that may be successfully used in the treatment of oesophageal stenoses of various aetiologies, allowing in most cases to avoid the surgical intervention.

Anesthesia, Local↗

PubMed1988

Modulation of natural killer cell activity by serum from cancer patients: preliminary results of a study of patients with colorectal adenocarcinoma or other types of cancer.

As previously reported for natural killer (NK) cells of normal individuals, prior incubation of peripheral blood lymphocytes from cancer patients with human normal serum or monomeric immunoglobulin G reduced their subsequent capacity to kill K562 target cells in a 4-h 51Cr release assay. The NK activity of such treated effector cells was significantly inhibited only by 58% of sera from patients with colorectal adenocarcinoma (21 of 36 cases) and by 67% of sera from patients with other lymphoid or nonlymphoid solid tumors (22 of 33 cases). The cytotoxic activity of cells previously incubated with eight noninhibitory sera was even augmented relative to medium-treated peripheral blood lymphocytes (control). The 26 untreated cancer sera which did not inhibit significantly the NK activity (I-) always developed significant inhibitory capacity upon heating at 56 degrees C for 30 min (delta+). An additional seven (21%) patients with colorectal carcinoma and four (27%) patients with other cancers were identified as having type II NK regulation, defined as sera with untreated inhibitory capacity (I+) but with appreciably more inhibition after heating (delta+). The sera of the last group of patients with colorectal adenocarcinoma (14 of 36 cases) defined as having type III NK regulation were not different from control sera isolated from normal individuals (I+ delta-) except that they induced an inhibition greater than that caused by normal sera. The modulatory characteristics of sera from the first two categories of patients appear to be cancer associated, since the patterns I- delta+ or I+ delta+ were observed with sera from only one of 30 patients with benign digestive diseases and two of 100 apparently healthy individuals. Preliminary results of longitudinal investigations of patients with colorectal adenocarcinoma revealed also that these patterns disappeared several months after resection of their tumor in all five tested patients, whereas the type III NK regulation found in patients with poor prognostic factors was unchanged after surgery in the other five of six patients. The three different categories of cancer sera identified by the functional assay of NK regulation indicated differences among our group of patients which were not paralleled by differences in levels of cytotoxic reactivity of their NK cells assayed in vitro in the absence of autologous serum.(ABSTRACT TRUNCATED AT 400 WORDS)

Adenocarcinoma↗

PubMed1975

[Surgical treatment of cancer of the thyroid (author's transl)].

The authors report their experience with cancer of the thyroid. Using statistical data from 760 operated cases and present day concept, they consider the difficulties of the diagnosis, the stage of evolution and the treatment in the form of a collaboration between surgery, clinic and nuclear medicine.

Adolescent↗

PubMed1973