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Biomedical subjects

A Origone

Publications and source records attributed to A Origone.

6 recordsLinked to original sources
PubMed1988

Controlled clinical study of the efficacy of a new low molecular weight heparin administered subcutaneously to prevent post-operative deep venous thrombosis.

A double-blind, placebo-controlled study was carried out in 100 patients undergoing major surgery to investigate the efficacy of a new low molecular weight heparin (LMWH) preparation in the prevention of deep venous thrombosis. Patients were allocated at random to receive either placebo or LMWH (7500 AXaU) each day by subcutaneous injection (abdominal fold method), starting 2 hours before the operation and continuing for the following 7 days. Clinical and laboratory tests revealed deep venous thrombosis in 3 (6%) patients in the placebo group whereas no thrombotic episodes were observed in any of the patients treated with LMWH. Blood loss during the peri-operative and post-operative period and the number of blood units transfused were not significantly different in the two groups. Moreover, no side-effects were revealed in the LMWH group that could be attributed to the drug.

Adolescent↗
PubMedDate not supplied

[Pulmonary arteriovenous fistula within the picture of congenital angiodysplasias. Clinical case].

The aetiopathogenesis, clinical picture, diagnosis and treatment of pulmonary arteriovenous fistula are examined in the light of a case observed at the Florence University Surgery Clinic in 1970 and marked by multiple truncular fistulae at the middle and inferior lobes of the right lung. The condition is seen as an instance of congenital angiodysplasia with arteriovenous shunt. A clear distinction is drawn between true fistulae, as seen in the reported case, and angioma and aneurysm. Stress is laid on the importance of radical management, though it is conceded that surgery should occasionally be renounced in the absence of symptoms, or where lung hypertension is particularly marked.

Angiocardiography↗
PubMedDate not supplied

A multicentre study on LMW-heparin effectiveness in preventing postsurgical thrombosis.

A multicentric study was carried out involving six italian departments of general surgery to assess the efficacy of a low molecular weight (LMW) heparin called Fluxum compared to standard calcium heparin in low doses for prevention of postoperative thromboembolic complications (deep vein thrombosis and pulmonary embolism). 610 patients were treated; 308 (50.5%) of whom were treated with Fluxum at doses of 4,000 or 8,000 I.U. Axa once a day by subcutaneous injection and 302 (49.5%) with heparin calcium at doses of 5,000 I.U. two or three times a day by subcutaneous injection. We observed a total of 29 deep vein thrombosis (4.7%); 10 (3.2%) from the group treated with LMW heparin and 19 (6.3%) from the comparative group. During the study 4 (0.65%) pulmonary embolism were found, 1 (0.32%) in the group treated with LMW heparin and 3 (1%) in the group treated with calcium heparin. None serious hemorrhagic accident was reported during the study. The antithrombotic prophy laxis carried out with Fluxum was on the whole better tolerated than the treatment of the other group, registering a lower frequency of hematomas at the injection and surgical wound sites.

Female↗