Biomedical subjects

A Ottaviano

Publications and source records attributed to A Ottaviano.

7 recordsLinked to original sources

PubMed1991

[Hazards of thrombolysis. A clinical case].

Thrombolytic therapy has led to a reduction in early and late mortality in myocardial infarction but it is not without its dangers. Two cases are reported in which it was adopted inadvisedly considering that later pathologies other than acute myocardial infarction were demonstrated. A less aggressive attitude is advised for emergency thrombolysis (pending the arrival of more effective, safer drugs) in the more peripheral centres where possible complications may be more difficult to handle.

Aged↗

PubMed1990

To assess the efficacy of prophylaxis in digestive tract surgery using a predictive model of complication risk.

One hundred and ninety-one patients, all candidates for major clean-contaminated surgery, were classified according to the risk of developing postoperative wound infection, using clinical and nutritional factors. A widely validated nutritional assessment model, the Prognostic Nutritional Index (PNI), was used preoperatively to evaluate the risk and probability of post-operative septic complications. Based on the predicted outcome, patients were assigned to either a poor or a good risk group for statistical comparison. A prospective, double-blind, randomized trial was performed to compare the effectiveness of the monocyclic beta-lactam, aztreonam, with gentamicin for short-term perioperative prophylaxis. In the poor risk group (PNI greater than 40), aztreonam prophylaxis significantly reduced postoperative septic complications (p less than 0.05). The use of an objective scoring system to assess the risk of postoperative sepsis is recommended for future studies on antibiotic prophylaxis as it offers a realistic assessment basis.

Aztreonam↗

PubMed1987