Biomedical subjects

A Ozsöz

Publications and source records attributed to A Ozsöz.

4 recordsLinked to original sources

PubMed2005

Incidence of cross resistance between rifampicin and rifabutin in Mycobacterium tuberculosis strains in Izmir, Turkey.

Rifabutin is a spiro-piperidyl-rifamycin derived from rifamycin-S. This study was planned to determine the minimal inhibitory concentrations (MICs) of rifabutin and rifampicin against Mycobacterium tuberculosis strains and to investigate cross resistance between two drugs. The agar dilution method was performed for detection of MICs of rifabutin and rifampicin for 112 M. tuberculosis strains obtained from patients with active pulmonary tuberculosis. Cross resistance between rifampicin and rifabutin was detected in 73.1%. Rifabutin MICs for rifampicin resistant strains were three- to four-fold higher than rifabutin-susceptible and/or -resistant strains' MIC values for rifampicin. Despite having 73% cross-resistance with rifampicin in M. tuberculosis isolates, it was concluded that rifabutin might be a valid component of combination therapy in rifampicin resistant tuberculosis cases when the isolate is tested and detected susceptible to rifabutin.

Drug Resistance, Multiple, Bacterial↗

PubMed2004

Sedation for fiberoptic bronchoscopy: fewer adverse cardiovascular effects with propofol than with midazolam.

OBJECTIVE: To study the influence of the sedatives propofol and midazolam on cardiovascular parameters in patients undergoing fiberoptic bronchoscopy (FOB). METHODS: 100 patients without a history of cardiac disease undergoing diagnostic FOB were investigated in a prospective-randomized design. After premedication with intramuscular atropine (0.01 mg/kg BW) patients received sedation with either propofol (group P, n = 50) or midazolam (group M, n = 50). Heart rate, arterial oxygen saturation (psaO (2)) and non-invasive blood pressure were recorded prior to and immediately after induction of sedation, when at the level of vocal cords, during the interventional diagnostic procedure (IDP) and 15 min after the end of the FOB. RESULTS: The mean heart rate and systolic pressure were significantly lower in group P when compared with group M when at the level of vocal cords and during the IDP (p < 0.05). The total incidence of major arrhythmias was 10 % and the incidence of minor arrhythmias was 62 %. A decline in psaO (2) < 90 % occurred in 16 patients of group M and 5 patients of group P (p = 0.44). CONCLUSION: Propofol, when used as a sedative for FOB, is associated with lower hemodynamic side effects than in patients undergoing FOB with midazolam. In addition, it is well-tolerated by patients with pre-existing pulmonary disease. Even patients without a history of heart disease should be monitored for cardiac arrhythmia while undergoing FOB for pulmonary disease, especially patients with a FEV (1) of less than 50 % of the predicted value.

Anesthetics, Intravenous↗

PubMed2001

Tuberculosis of oral mucosa.

In secondary tuberculosis, lesions of the oral cavity may accompany lesions of the pharynx, lungs, lymph nodes or miliary tuberculosis. A 35-year-old male was suffering from swelling of his right cheek, cough, weakness and weight loss. There were local hyperemia and irregular oral mucous in the inner part of the right cheek. Chest x-ray showed bilateral nodular opacifications and a cavity of 2 cm. Acid-fast bacteria were present in sputum and Lowenstein-Jensen culture was positive. The pathological signs of the biopsy taken from the buccal mucosa including multistratified squamous epithelium were: tubercle structure, Langhans' giant cells and minimal cazeation necrosis. After anti-tuberculous chemotherapy oral and pulmonary lesions were almost in remission. Following this case report of lung tuberculosis accompanied by tuberculosis of oral mucosa, the literature related is reviewed.

Adult↗

PubMedDate not supplied

Endobronchial low-grade MALT lymphoma causing unilateral hypertranslucency.

Mucosa-associated lymphoid tissue-derived lymphoma (MALT lymphoma) arises not only from the stomach but also from various non-gastrointestinal sites. A thirty two year old woman, suffering from breathlessness for one year, had been treated for bronchial asthma. A chest radiograph showed a mediastinum and heart transposition to the right side and emphysema of the left lung. In the thorax spiral tomography, a mass narrowing left main bronchi, five centimeters in length from the carina, was seen. A fiberoptic bronchoscopy revealed millimetric polypoid lesions those nearly totally obstructed the left main bronchi. The bronchoscopic biopsy showed a diagnosis of MALT lymphoma. She was seen for check-ups following chemotherapy but no further treatment has been carried out.

Adult↗