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Biomedical subjects

A P Andreeva

Publications and source records attributed to A P Andreeva.

18 recordsLinked to original sources
PubMed1992

[Transferrin iron-binding capacity in hypersideremia].

Three methods for evaluation of serum iron-binding capacity have been described: biochemical, immunological based on transferrin assay, and biophysical based on electron-paramagnetic resonance (EPR) spectroscopy of transferrin. Interrelation has been shown between transferrin and general serum iron-binding capacity. Basing on the data presented it is suggested that in secondary hemochromatosis plasma contains an iron pool that is not specifically bound with transferrin, while in primary hemochromatosis such pool was not detected.

Humans↗
PubMed1992

[Erythrocytic ferritin in pregnant women and infants in the first year of life].

Erythrocytic ferritin levels were followed up in pregnant women with reference to its course, in newborns, and in infants during the first year of life. It is shown that the level of erythrocytic ferritin remains high enough in women with complicated pregnancy attended by a sharp reduction of iron reserves. No clear dependence of erythrocytic ferritin concentration on the character of the antenatal period course was observed in infants. The highest values of erythrocytic ferritin parameters were recorded by the first month and they decreased constantly by the first year of life.

Erythrocytes↗
PubMed1992

[Iron metabolism in anemia patients with no deficiency of iron reserves].

Iron metabolism was studied in anemia patients with no iron deficiency. The data obtained have suggested that iron transport to blood-synthesizing cells i disturbed in such patients with normal iron reserves. Basing on the study of iron metabolism and red blood parameters in the patients after the treatment by hypoxic hypoxia it is shown that this method combined with iron therapy can be successfully used for the treatment of this form of iron deficiency anemia.

Adult↗
PubMed1979

[Peroxidase activity of hemoglobin, modified at the carboxylic groups of heme and amino acids].

The effects of modification of heme carboxylic groups by omega-aminoenantic acid and L-phenylalamine on the peroxidase activity of hemoglobin were studied. For this purpose the peroxidase activities of the original compounds--hemin, hemin-aminoenantic acid, hemin-phenylalanine and hemoglobins prepared from the hemin and globin compounds--hemoglobin, aminoenantyl-hemoglobin and phenylalanine hemoglobin--were determined. The dependence of the peroxidase activity of these compounds on their concentrations and pH was analyzed. It was shown that 40--50% modification of the heme carboxylic groups by amino acids decreases the peroxidase activity of the modified hemins and that of modified hemoglobins reconstructed from these hemins and globin. A decrease of the catalytic activity of the hemoglobin derivatives is due to a lower peroxidase activity (as compared to hemin) of the modified hemins. It is thus concluded that the amino acid modification of the carboxylic groups of heme does not affect the heme-protein interactions in the hemoglobin molecule.

Amino Acids↗
PubMed1979

[Dependence of the rate of aspartate ammonia-lyase reaction catalyzed by free and immobilized cells of E. coli on temperature and preliminary thermal treatment].

The effects of temperature (45--55 degrees) and duration of thermal treatment on the L-aspartase activity of free and immobilized on polyacrylamide gel cells of E. coli, strain 85 were studied. It was found that preliminary thermal treatment of the cells at 50 degrees for 40--60 min is optimal for a high aspartase activity. Within the temperature interval of 20--55 degrees the temperature dependence of effective rate constants of L-aspartate synthesis obeys the Arrhenius equation, whereas the effective energy of activation is decreased from 12,6 to 3,6 kcal/mole, when the "activation" of the cells shows an increase.

Ammonia-Lyases↗
PubMed1976

[The role of subclinical forms of epidemic parotitis in the formation of collective immunity].

A study was made of the outbreaks of epidemic parotitis in kindergartens and schools. Of 276 children aged from 2 to 13 years 58 (21%) sustained clinically manifest infection and 48 (17.4%)--a subclinical one. The clinically manifest process mostly developed in children aged from 3 to 5 years: the ratio of the clinical and subclinical forms in them constituted 1:0.5. With the progress of age there was an increase in the proportion of the subclinical forms (in 10--13-year-old children this ratio was 1:1.3). The presence of blood antihemagglutinins in the titre of up to 1:64 before the infection failed to prevent the development of the infectious process. There was no correlation between the antibody titre and the severity of the infectious process. Subclinical cases of parotitis were accompanied by less intensive antibody production than the clinically manifest ones.

Adolescent↗
PubMed1975

[Incidence of epidemic parotitis in different countries].

The authors analyzed the incidence of epidemic parotitis in various countries in 1960--1969 on the basis of the data published by the WHO. It can be supposed that there was no significant difference in the morbidity in various countries and that discrepancy in the official data of individual countries was apparently caused by the errors in recording. In the majority of the countries morbidity curve was fluctuating in character with a 4--5-year periodicity. In the countries of the northern hemisphere the greatest number of cases occurred in spring, and in the southern--in autumn. Monthly distribution of cases during the years with a high and low morbidity level displayed no significant changes.

Africa↗
PubMedDate not supplied

[Measles antibody in patients with multiple sclerosis at different stages of the disease].

Sixty-nine patients with multiple sclerosis from 12 to 53 years of age were examined. The titre of measles antibody in the blood serum (geometric mean) was 9.0 log2 in the patients and 5.1 log2 in normal subjects of the control group. The antibody titre was found to depend upon the stage of the disease: the sera collected in the period of remission had a titre of 7.3 log2, and those collected in the exacerbation stage 10.7 log2. Nineteen patients were examined both during remission and at the time of exacerbation: their antibody titres were 6.8 and 10.7 log2, respectively. The antibody titre did not depend upon duration of the disease, sex or age of the patients. Antibody in the cerebrospinal fluid was detected in 3 out of 8 patients in the stage of remission and in 6 out of 9 patients in the stage of exacerbation. In 4 out of 11 patients, measles immunoglobulins of the M class were found by means of serum fractionation in sucrose density gradient.

Adolescent↗
PubMedDate not supplied

[L-asparatic acid synthesis from ammonium fumarate by free and immobilized Escherichia coli cells].

E. coli 85 cells with a high aspartate-ammonia-lyase activity were immobilized through polyacrylamide gel incorporation. Proper conditions to assay aspartase activity of E. coli cells were developed. Kinetic patterns of aspartate-ammonia-lyase reaction catalyzed by free and immobilized E. coli 85 cells were studied. The synthesis of L-aspartic acid from ammonium fumarate had the following characteristics: specific activity of (4--6) . 10(-5) mmole/mg.sec for free cells and (6--8) . 10(-5) mmole/mg.sec for immobilized cells with their content in polyacrylamide gel of 5--10 mg protein per g wet gelm pH 8.3--10.0.

Aspartic Acid↗
PubMedDate not supplied

[Mobility of collagen structure and temperature adaptation of animals].

The method of hydrogen exchange is used to determine the mobility of acid-soluble collagen molecules from animals with different physiological temperature in terms of equilibrium constants of the formation of micro-unfolding or fluctuating defects of the structure. It has been shown that mobility of the collagen structure correlates with the physiological temperature of the animal from whose tissue collagen was isolated and is mainly determined by the amino acid content of the collagen. It has been shown also that at physiological temperatures characteristic for a particular species the level of collagen mobility is of the same order despite their different thermostability. The conclusion has been drawn that the level of mobility is the main criterion at the natural selection of the amino acid composition of collagens in different animals.

Adaptation, Physiological↗
PubMedDate not supplied

[Role of quaternary structure in the antigenic specificity of amino acid derivatives of hemoglobin].

Immunochemical properties of isolated alpha- and beta-chains of aminoenanthyl- and phenylalanyl-hemoglobins were studied by fixation of the complement as compared with the corresponding chains of the native hemoglobin. In spite of the immunochemical differences between Phe-Hb and hemoglobin, the complement fixation ability was shown to be the same in Phe-Hb, AE-Hb and hemoglobin; this phenomenon suggests that formation of the antigenic determinant in Phe-Hb occurs at the level of quaternary structure.

Animals↗