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Biomedical subjects

A P Angelopoulos

Publications and source records attributed to A P Angelopoulos.

At least 19 recordsLinked to original sources
PubMed1990

Lateral periodontal cyst. Review of the literature and report of a case.

The lateral periodontal cyst is a rare odontogenic cyst of developmental origin. It occurs on the lateral periodontal region of a vital tooth and has specific histologic features. In this paper a case of a lateral periodontal cyst is presented and cases previously reported in the literature are reviewed. The present case concerns a 50-year old woman who presented for an asymptomatic gingival swelling of the left canine mandibular region of 2 month's duration. X-ray examination showed a well circumscribed radiolucency with a radiopaque margin lying between the roots of the lateral incisor and canine. The associated teeth were vital. Enucleation of the lesion was performed. The histologic examination of the specimen showed a cyst lined by thin non-keratinized epithelium with focal thickenings containing clear cells.

Connective Tissue↗
PubMed1990

[Polymorphous low-grade adenocarcinoma of the minor salivary glands. A case report and review of the literature].

Polymorphous low-grade adenocarcinoma is a distinct type of salivary gland carcinoma arising most often intraorally and primarily in the palate. It is characterized by bland nuclear chromatin, variation in histomorphology and low-grade malignancy. We report a case of this recently described entity in a 66 year old male, presenting most of the characteristic clinical and histologic features. A short review of the current literature concerning this tumor is included.

Adenoma, Pleomorphic↗
PubMed1988

Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases.

The clinical and histopathological features of 224 new cases of peripheral giant cell granuloma were studied. In addition, the data from 956 previously reported cases in the literature were evaluated and compared with the present series. Females were found to be more commonly affected than males. All age groups were found to be affected with a relative predilection from 40 to 60 years of age. The mandible was more often affected than the maxilla. Clinically, the lesions were red in color, had a smooth surface and were rubbery or with a soft consistency. The most characteristic histologic features included a non-encapsulated highly cellular mass with abundant giant cells, inflammation, interstitial hemorrhage, hemosiderin deposits, mature bone or osteoid.

Adolescent↗
PubMed1987

The therapeutic effect of an aromatic retinoid (RO-109359) on hamster buccal pouch carcinomas.

Forty male hamsters were divided into three groups. Group 1 (16 animals) received topical applications with a 0.5% solution of DMBA in liquid paraffin on the right buccal pouch for 16 weeks. Group 2 (16 animals) received DMBA for 16 weeks, plus the retinoid RO-109359 three times during the 17th week in doses of 200 mg/kg. Group 3 (8 animals) remained untreated for 16 weeks and, during the 17th week, received the retinoid as in group 2. After administration of the retinoid, a marked regression in the size of the carcinomas of the right pouch in group 2 animals was observed clinically. Histologically, these tumors consisted mostly of large necrotic areas and showed an excessive keratin loss. Although the hypervitaminosis A symptoms could not be avoided, the findings suggest that high doses have a therapeutic effect on hamster buccal pouch carcinomas.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1986

Sister chromatid exchanges in lymphocytes of patients with oral carcinoma.

Sister chromatid exchanges (SCEs) were studied in cultured peripheral lymphocytes of 22 untreated patients with squamous cell carcinoma of the oral cavity and 29 age- and sex-matched controls. The SCE rate in cancer patients was not significantly higher compared with that found in controls, but there was a significant correlation between the SCE rate in lymphocytes of the cancer patients and the size of the primary tumor.

Aged↗
PubMed1986

Chromosomal breaks and sister chromatid exchanges (SCE) in patients with herpetic stomatitis.

Chromosomal breakage and sister-chromatid exchanges (SCE) were studied in peripheral lymphocytes of 9 patients with primary herpetic stomatitis (PHS), 12 patients with secondary herpetic stomatitis (SHS) and 12 controls. The incidence of chromosomal breakage was significantly higher in PHS patients (mean 23%, P. = 0.0002) and in SHS patients (mean 20.25%, P. = 0.0003) compared to the controls (mean 4.2%). The incidence of SCE per 46 chromosomes was significantly higher in SHS patients (mean 16.564) compared with (P. less than 0.001) the controls (mean 11.367) and compared with (P. = 0.006) the PHS patients (mean 12.131). It is concluded that both PHS and SHS patients exhibit structural chromosomal damage; SHS patients in addition exhibit more repaired chromosomal lesions.

Adolescent↗
PubMed1983

Serum immunoglobulins and complement (C'3) in oral lichen planus.

Serum immunoglobulins and complement (C'3) were determined by single radial immunodiffusion according to the method of Mancini and co-workers in fifty patients with oral lichen planus and twenty persons with clinically normal oral mucosa. Significantly increased levels of serum IgG (p less than 0.05) and a significant reduction of serum IgA concentration (p less than 0.05) in the experimental group as compared with normal controls were observed. Mean serum IgM and complement (C'3) levels were similar in patients and controls. No correlation between disease variety or extensiveness and immunoglobulin or complement levels was noticed. These results suggest that patients with oral lichen planus may have a generalized immunologic disorder in which humoral immunity is disturbed. Whether humoral immunity is of etiologic significance, contributes to the disease process, or, finally, represents an event secondary to the pathologic changes seen in the disease remains to be determined.

Adult↗
PubMed1983

Karyotypic abnormalities of squamous cell carcinoma of the oral cavity.

The karyotypic abnormalities in 18 squamous cell carcinomas of the oral cavity were studied in unbanded chromosomes on direct preparations of the tumor material. The chromosome counts revealed a great variability in the number of chromosomes per cell of each tumor, the range being from 31 to 148 in all cases studied. The modal population of cells was diploid in five cases, triploid in eight cases, tetraploid and pentaploid in one case each. Reduction of the number of chromosomes was more consistently observed in groups A and B, frequently involving chromosome No 1 and increases in groups C, D, E, F and G. Markers were frequently present, the most common being an almost metacentric chromosome of the size of the chromosomes of Group C.

Aged↗
PubMed1979

Simultaneous presence of partial anodontia and supernumerary teeth.

The literature is reviewed and three cases of simultaneous presence of partial anodontia and supernumerary teeth are reported. In all three cases the abnormality involved both the maxilla and the mandible. The role of the panoramic radiograph in the detection of rare cases of this kind is emphasized and illustrated.

Adolescent↗