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Biomedical subjects

A P Barrett

Publications and source records attributed to A P Barrett.

At least 19 recordsLinked to original sources

Oral complications in type 1B glycogen storage disease.

A case of type 1b glycogen storage disease (GSD) in which neutropenia and neutrophil dysfunction were prominent features is described. Oral complications included rapidly progressive periodontal disease and recurrent mucosal ulceration.

Adult

Herpes zoster virus infection: a clinicopathologic review and case reports.

Herpes zoster virus (HZV) infection, particularly of the trigeminal nerve, can be a disabling and disfiguring condition with variable clinical presentations. Acyclovir is a highly effective treatment modality during the acute clinical phase; however, pain control may be very difficult particularly with protracted and severe post herpetic neuralgia (PHN). The clinicopathologic features are reviewed and two cases in immunosuppressed patients with HZV infection of different divisions of the trigeminal nerve are presented.

Acute Disease

The teaching of dento-maxillo-facial radiology in Australian dental schools.

The skills necessary to successfully perform radiological procedures in general dental practice are described and should be used as criteria when developing an effective undergraduate curriculum and as determinants of the contents of continuing education programmes. The present status of undergraduate curricula. continuing education, and postgraduate programmes as well as the recognition of the specialized nature of dento-maxillo-facial radiology, are discussed and recommendations for future developments are made.

Australia

Facial cellulitis responsive to flucloxacillin in acute leukemia.

A severely neutropenic patient, undergoing bone marrow transplantation for acute leukemia, experienced bilateral facial cellulitis accompanied by high fever and a facial folliculitis. All resolved with the addition of flucloxacillin to existing antibiotics suggesting a causal role for staphylococci.

Acute Disease

Metronidazole in the management of anaerobic neck infection in acute leukemia.

A case involving a rapidly progressive neck infection in a severely neutropenic patient with acute leukemia is reported. Resolution followed the addition of metronidazole to an existing standard piperacillin/gentamicin combination, which was used primarily to cover potential gram-negative bacillary pathogens. This indicated the importance of considering extension of anaerobic cover in such infections.

Adult

Chronic indolent orofacial herpes simplex virus infection in chronic leukemia: a report of three cases.

Orofacial mucocutaneous infections caused by herpes simplex virus (HSV) may exhibit a distinct chronic indolent pattern of behavior in some immunosuppressed patients as opposed to the more familiar aggressive patterns. Three patients with chronic leukemia who illustrate this chronic indolent pattern are presented. These cases should alert the clinician to the variable clinical appearance that HSV may adopt in the immunosuppressed patient.

Aged

Oral complications of high-dose melphalan in multiple myeloma.

Four patients with multiple myeloma refractory to conventional chemotherapy received high-dose melphalan. All experienced multiple oral complications. Extensive neutropenic ulceration and orofacial herpes simplex virus infection caused considerable morbidity in three patients during prolonged periods of neutropenia.

Adult

Clinical characteristics and mechanisms involved in chemotherapy-induced oral ulceration.

The clinical characteristics of chemotherapy-induced oral mucosal ulceration in a group of patients with acute leukemia were examined in detail in a long-term prospective clinical study. Differences in regional susceptibility within the mouth to the effects of chemotherapy were apparent. A reconstruction of the probable mechanisms involved is presented.

Acute Disease