Biomedical subjects

A P Bogdanov

Publications and source records attributed to A P Bogdanov.

8 recordsLinked to original sources

PubMed1996

[Myocardial tomoscintigraphy with 201Tl in the diagnosis of cardiac involvement in systemic scleroderma].

Myocardial microcirculation was assessed in 23 scleroderma systematica patients using 201Tl tomoscintigraphy at rest (23 patients) and upon dipyridamole vasodilation (6 patients). Most patients were found to have impaired blood supply of the myocardium with sites of myocardiofibrosis. In response to dipyridamole introduction improved myocardial perfusion was registered in 4 out of 6 patients, 1 patient showed signs of transient myocardial ischemia, 1 patient had stable defects of myocardial blood supply. It is suggested that some sclerodermic patients may benefit from vasodilators.

Adult↗

PubMed1995

[Myocardial scintigraphy with thallium-201 in the diagnosis of cardiac involvement in systemic scleroderma].

201Tl scintigraphy of the myocardium is a highly sensitive method of diagnosis of cardiac damage in SS. More severe lesions occur in patients with diffuse skin affections and subacute SS. Improvement of perfusion in dipiridamol test indicates the contribution of the spasm of microcirculation coronary vessels to the onset of perfusion defects. Further investigations are needed for evaluation of the role various vasodilators have in prevention of perfusion lesions and progressive myocardial fibrosis in SS patients.

Adult↗

PubMed1995

[The assessment of left ventricular diastolic function in patients with systemic scleroderma by radionuclide ventriculography].

To assess left ventricular (LV) diastolic function in scleroderma systematica (SS) with regard to SS course and skin lesion degree, a total of 24 SS patients were examined versus control subjects. Though cardiac symptoms manifested clinically only in 8 patients, parameters of LV diastolic function underwent changes in the majority of the examinees: the time to attaining maximal filling velocity increased, contribution of the first diastolic third to LV filling diminished, hemodynamic significance of the left atrial systole grew. More pronounced dysfunction of the myocardium occurred in patients with diffuse skin lesions, acute and subacute disease who also appeared to have reduced LV ejection fraction. The conclusion is made on frequent subclinical pattern of myocardial involvement in SS patients which runs primarily as LV diastolic dysfunction. Systolic disturbance emerge later or in more active forms.

Acute Disease↗

PubMed1994