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Biomedical subjects

A P Leca

Publications and source records attributed to A P Leca.

15 recordsLinked to original sources
PubMed1986

[Penicillamine in 1985].

After reviewing the history of the discovery of the action of D-penicillamine in rheumatoid arthritis, the authors define the practical modalities for the management of treatment based on their own experience and on the data from the literature. The therapeutic score remains relatively low because of the frequency of side effects and therapeutic escapes, even when an encouraging result has been obtained during the first years of treatment.

Adolescent↗
PubMed1977

[Study of optimal posology of penicillamine in the treatment of common rheumatoid polyarthritis (apropos of a personal series of 200 cases)].

A comparison of two series of patients with rhe,matic polyarthritis, the one (n = 140) treated with dosage equal to or higher than 900 mg, the other (n = 60) with dosage between 600 and 750 mg, did not reveal significant difference in clinical and biological efficacy. The number of side-effects was not significantly reduced by lower dosage, except for digestive tract disorders. A reduction of dosage does, therefore, not permit less strict supervision and monitoring for side-effects of treatment.

Arthritis, Rheumatoid↗