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Biomedical subjects

A P Peltier

Publications and source records attributed to A P Peltier.

At least 19 recordsLinked to original sources
PubMed1993

[Polyarthritis in 4 patients treated with intravesical BCG-therapy for carcinoma of the bladder].

Intravesical administration of Calmette-Guérin bacillus (BCG) is effective in the treatment of superficial bladder carcinoma. Transient arthritis or migratory arthralgia has been reported in 0.5% of cases. The authors report on four men (mean age 65 years), who developed an oligoarthritis in three cases after the 2nd, 5th, and 6th weekly instillation of Pasteur BCG, respectively, and symmetrical polyarthritis in one after 48 BCG instillations over a three-year period. Joints involved were the knees (3/4), ankles (3/4), shoulders (1/4), wrists, and hands (1/4). Features included morning stiffness and local evidence of inflammation. All four patients had an elevated erythrocyte sedimentation rate and negative tests for rheumatoid factor. Neutrophils were the main cell type in synovial fluid. Synovial biopsy performed in two cases revealed non-specific inflammation. Erosions of the metatarsophalangeal joints were observed in one patient. Locoregional or systemic symptoms included transient fever (3/4), cystitis (4/4), urethritis (1/4), epididymoorchitis (2/4), conjunctivitis (1/4), and pleural effusion with pericarditis (1/4). The BCG was recovered from an epididymal specimen in one patient. Two patients were positive for the HLA B27 antigen. Outcome was favorable in every case (range: 15 days-6 months) after discontinuation of BCG therapy and administration of isoniazid, rifampin, and prednisone (3 patients) or NSAID (1 patient). Various pathogenic hypotheses for BCG-induced arthritis are discussed, including infection, immune responses to heat shock proteins, and reactive arthritis.

Administration, Intravesical↗
PubMed1989

Practical management of NSAID gastropathy in rheumatic patients.

Gastropathy is a relatively common complication of treatment with a non-steroidal anti-inflammatory drug (NSAID). Pre-treatment evaluation of patients is therefore of key importance. Contraindications for NSAID treatment may include a history of gastroduodenal ulcer or of NSAID gastropathy, simultaneous administration of anticoagulant therapy and the existence of risk factors for ulcer disease. After NSAID treatment has begun, clinical follow-up is highly desirable. NSAID gastropathy can be asymptomatic despite the presence of a broad spectrum of gastrointestinal mucosal changes on endoscopy, but in the majority of cases there are clinical symptoms. Management of gastropathy may involve withdrawal of NSAID treatment, replacement therapy with a different type of drug or post hoc treatment of the gastropathy with anti-ulcer compounds.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1986

[Chemotaxis and collagen].

The authors evaluate the chemotactic properties of collagen and collagen derived fragments, according to literature datas. In experimental conditions, collagen can be chemotactic for human blood monocytes, fibroblasts and various malignant cells but not polymorphonuclear. The meaning of these facts and their possible role in the genesis of osteo-articular diseases are also discussed.

Chemotaxis↗
PubMed1983

[Significance of reduced complement level in the articular fluid. 81 cases].

Based on their own experience, the authors report that a fall in the complement level of joint fluid, which is particularly common in rhumatoid arthritis, is also seen in cases of systemic lupus eryrthematosis and a variety of arthritis: infectious arthritis, gout, articular chondrocalcinosis and psoriatic rheumatism. This should be taken into account when evaluating the diagnostic value of this test in rheumatoid arthritis.

Arthritis, Infectious↗
PubMed1982

[Rheumatoid arthritis with antinuclear factor. A prospective study of 50 cases (author's transl)].

The clinical and laboratory features of rheumatoid arthritis (RA) with antinuclear factor (ANF) were prospectively analyzed in 50 patients and compared with those of another series of 50 patients of similar age, sex and duration of disease, but without ANF. The severity of articular lesions was about the same in both series, but systemic symptoms and Gougerot-Sjögren syndrome occurred more frequently in patients with ANF. Gold compounds and D-penicillamine appeared to be well tolerated by all patients. RA patients with ANF had more strongly positive responses to latex and Waaler-Rose tests. Farr's radioimmunoassay was sometimes positive (11/49), but as a rule, the degree of positivity was inferior to 50%.

Adult↗
PubMed1981

[Evolutive aspects of Sharp's mixed connective tissue disease. 23 cases (author's transl)].

Among 23 patients with Sharp's disease, 14 initially had only polyarthritis, Raynaud's syndrome and anti-ribonucleoprotein antibodies. During a mean 5.6 years (range: 1-7 years) follow-up these 14 patients, 2 cases of pericarditis, 1 case of trigeminal neuralgia, 2 cases of nephropathy and 1 case of pulmonary arterial hypertension were observed. The 9 remaining patients had symptoms of multiple collagen disease. They were followed up for a mean of 4.3 years (range: 3-7 years) and 3 developed pericarditis. We discuss the prognostic significance of anti-DNA antibodies (7 cases) and low serum complement (3 cases) which, when combined, seem to be associated with severe visceral lesions.

Antibodies, Antinuclear↗
PubMed1981

[Consumption hypocomplementemia: relation between hemolytic and immunochemical assays of C4 in serum (author's transl)].

The aim of the study is to compare two methods for the measurement of the fourth human complement component through its hemolytic activity and immunodiffusion properties in 35 healthy subjects and 35 patients with immunological complement depletion. For the healthy subjects, the results show a highly significant correlation between the two methods (the coefficient of correlation is + 0.80). On the contrary, there is no correlation between the two assays for the patients suffering from consumption hypocomplementemia. The reasons of this discrepancy are discussed.

Adolescent↗
PubMed1981

[Comparison of consumption kinetics of the C4 and C2 components of complement by immune complexes "in vitro" (author's transl)].

We study the consumption kinetic of the fourth and second component of complement by the C1 esterase in different systems with EA or EAC1 and fresh NHS, or functionally purified C4 and C2 preparations. The results show that the two kinetics are similar with a comparable decrease in both C4 and C2 activities till 90 seconds (the mean residual values are from 21 to 34% at this time). The results show moreover that the consumption of the C2 component requires necessarily the presence of the C4 component. The C4 reaction kinetic compared with the C2 "in vitro" one refutes the hypothesis of a greater sensitivity of the C4 component compared with the C2, for the enzymatic action of the C1 esterase. So, a discrepancy in the reaction speed cannot be evoked in order to explain the obvious C4 depression in the consumption hypocomplementemia, and different hypothesis have to be investigated, such as, for instance, a lower synthesis rate of the C4 component compared with the C2 one.

Animals↗
PubMed1980

Cellular junctions in normal and inflammatory human synovial membrane revealed by tannic acid and freeze fracture.

Cellular junctions between synovial cells and endothelial cells of the microvasculature were examined in 10 normal and 20 inflammatory human synovial membranes by means of tannic acid and freeze fracture, Gap junctions and desmosomes predominated on synovial cells, and tight junctions in the microvasculature. Comparison between normal and inflammatory synovial membranes did not demonstrate changes in cellular contacts that might be caused by inflammation.

Desmosomes↗
PubMed1980

Fulminant meningococcemia in a child with hereditary deficiency of the seventh component of complement and proteinuria.

A previously healthy 14-year-old boy presented with fulminant meningococcemia. He was found to have a total deficiency of C7. His serum totally lacked bactericidal activity against Neisseria meningitidis. Addition of purified C7 restored the serum hemolytic and bactericidal activity. Susceptibility to disseminated Neisseria infections has previously been reported in 3 patients with C7 deficiency, as well as in a few patients with deficiency of C5, C6 and C8. These findings emphasize the importance of intact complement mediated bactericidal activity in host defense against disseminated Neisseria infections. Evaluation of the complement system in individuals with Neisseria infections appears mandatory.

Adolescent↗
PubMed1980

Human deficiency of the sixth component of complement in a patient with meningococcal meningitis and no haemostasis abnormality.

A case of human complete C6 deficiency is reported. The patient, a 31 year old white male, was seen on the occasion of an isolated episode of meningococcal meningitis. Serum complement hemolytic and bactericidal activities were lacking and could be restored to normal by addition of appropriate amounts of purified C6. No hemostatic abnormalities were observed.

Adult↗
PubMed1980

[Renal histology in 44 patients with specific antibodies of soluble nuclear antigens].

The authors studied the correlations between renal histology and specific antinuclear antibodies of soluble nuclear antigens (anti-Sm, anti-RNP, anti-protein) in 44 patients with such auto-antibodies. They were mostly patients with lupus erythematosus (35/44), more rarely mixed collagen disease or Sjögren's disease. The presence of any one of the specific antibodies of nuclear antigens is not associated with any special renal prognosis; thus the presence of anti-RNP does not mean that there are no histological renal lesions. The renal prognosis depends in fact on the presence of anti-ADN native antibodies. Among the other laboratory parameters (rheumatoid factors, complement levels, cryoglobulinemia) only hypocomplementemia seems to be associated with a poor renal prognosis, the presence of rheumatoid factor has perhaps a protective role.

Adolescent↗
PubMed1980

Deficiency of the second component of complement. Its occurrence with membranoproliferative glomerulonephritis.

We studied glomerulonephritis in a child with a deficiency of the second component of complement (C2) who was without clinical or serologic evidence of systemic disease. The clinical course was severe, with malignant hypertension and terminal renal failure when the child was 14 years old. Results of histologic studies were typical of membranoproliferative glomerulonephritis with subendothelial deposits. Immunofluorescence microscopy showed diffuse and intense localization of IgG, C1q, and C4 as granular deposits along the glomerular capillary walls and within the mesanguim. Diffuse deposits of C3 were also found along the capillary walls. Nine months after transplantation, the graft biopsy specimen showed glomerular lesions with IgG, C1q, C4, and C3 deposits, which suggests the possibility of a recurrence. The analysis of the previously reported cases of glomerulonephritis with C2 deficiency showed variable, but generally mild, glomerular lesions. Progression of the glomerulonephritis to severe renal insufficiency, as in the present case, is exceptional.

Adolescent↗
PubMed1980

[Synovial vascularization and inflammation. I. Morphologic study using light and electron microscopy].

The authors studied using light and electron microscopy, 40 cases of sub-acute inflammatory synovitis (including 24 cases of rheumatoid synovitis) and 10 normal synovia. In light microscopy, the study dealt with images of capillary congestion, endothelial hyperplasis and capillary obliterations. In electron microscopy the morphology of the capillaries, the images of plasmic exsudation, images of extravascular cell migration and vascular obliteration by the endothelial cells, were studied in comparison with the inflammatory synovitis and the normal synovia. Inflammatory synovitis are characterized by the frequency of extracapillary cell migrations without there being any other pathological change of the microvessels that can be attributed to inflammation.

Capillaries↗