Biomedical subjects

A P Reid

Publications and source records attributed to A P Reid.

10 recordsLinked to original sources

PubMed1992

Preparation of aqueous standards for low temperature X-ray microanalysis.

A technique, using Nuclepore polycarbonate membrane filters as a containing medium for very small volumes of ionic standard solutions, to produce homogeneous ice standards is described. The standards are suitable for use in a scanning electron microscope. The relationship between elemental X-ray counts and ionic concentration is found to be linear. The method is rapid and simple. Minimum detectable concentrations are given.

Electron Probe Microanalysis↗

PubMed1991

Distribution of ear drops in normal ears.

Ear drops are prescribed widely with little thought for the distribution inside the ear canal. This study compares the distribution of water and oil based drops. The results indicate that, under the test conditions, the penetration of ear drops is extremely variable. Water provided the greatest overall coverage, while the most viscous drops fared worst. It is suggested that in diseased ears even poorer penetration may result, which may explain the lack of response in some circumstances.

Adult↗

PubMed1991

Staging carcinoma: its value in cancer of the larynx.

Three thousand four hundred and forty-five cases of cancer of the larynx were examined and 3,235 assigned to their TNM group. While good correlation with prognosis could be seen, the value of the detailed subsite (as opposed to the main laryngeal regions) was limited to defining T1a and T1b and aiding that of T2. T status gives some indication of prognosis, but the N status is of almost overriding importance.

Female↗

PubMed1991

Distribution of ear drops using a non-aerosol spray delivery system.

The distribution of ear drops in normal ears is variable. A new product Otomize (Stafford-Miller) containing dexamethasone and neomycin has a non-aerosol spray mist delivery system. This has been applied to normal ears and found to be superior in its distribution to generally available ear drops previously assessed.

Administration, Topical↗

PubMed1991

Post-laryngectomy stomal recurrence: tumour implantation or paratracheal lymphatic metastasis?

In the treatment of obstructing laryngeal cancer, an association has often been noted between emergency tracheotomy for airway relief and subsequent post-laryngectomy stomal recurrence. It is however unclear whether this is due to tumour implantation in the tracheotomy track, or paratracheal lymph node metastasis. To investigate the pathophysiology of stomal recurrence, the recurrence rate and clinical outcome of 26 cases of T3N0M0 glottic cancer treated with emergency tracheotomy and subsequent laryngectomy were analysed, and compared with 65 stage-matched cases treated with laryngectomy alone. Analysis shows the 'emergency tracheotomy' group to have a very poor prognosis with a higher incidence of recurrence at the stoma, and also in the regional lymph nodes. These findings suggest that paratracheal lymph node metastasis is an important mechanism in the development of stomal recurrence and thus has considerable implications for the prevention of such a recurrence following laryngectomy in the patient presenting with malignant airway obstruction.

Carcinoma, Squamous Cell↗

PubMed1989

Localized middle ear effusions: three unusual acute cases in adults.

Three cases of acute, non-suppurative otitis media in adults are described. They are unusual in that the effusion was confined to the upper middle ear, whilst the lower middle ear was aerated. The aetiology of such localized effusions, is probably related to the anatomy of the middle ear compartments, the mucosal folds forming them and the apertures allowing communication between them. The compartments are relatively constant and are a result of the embryological development of the middle ear. The localization of these effusions, demonstrates the segmental anatomy of the middle ear.

Acute Disease↗

PubMed1989

Surgical approach to the parotid gland.

The key to surgical treatment of the parotid gland is adequate exposure and careful identification and protection of the facial nerve. The superficial and deep lobes of the gland can be removed from external approaches with little or no damage to the facial nerve if a careful and thoughtful surgical technique is employed.

Humans↗

PubMed1988

Why do tympanostomy tubes block?

One hundred extruded Shah tympanostomy tubes were recovered from the ears of children following surgical treatment of otitis media with effusion. They were examined both macroscopically and microscopically for the presence of luminal blockage. The lumen was blocked by eosinophilic material with a polymorphonuclear leucocyte infiltrate in 56% of cases and the base of the extruded tube was covered by a cast of squames in 70% of cases. The occurrence of luminal blockage was associated with the presence of a thick middle ear effusion.

Child↗

PubMed1988

Neonatal septal deviations.

In a review of 1000 consecutive neonates of all races, nasal septal deformity was identified in 29, an incident of 2.9%; significantly fewer cases were found in negroid babies (0.1 greater than P greater than 0.05). Ten cases (35%) underwent manipulation of the deviated septum. Six-monthly review revealed that symptoms associated with the septal deformity are rare. In 7 (44%) of the 16 cases not manipulated, the septum straightened spontaneously during the first few months of life. The appearance of the deviation is not of a dislocation of the caudal edge of the cartilage but a smooth concavity. In vitro compression of the neonatal nasal cavity reproduced this C-shaped deformity, but only temporarily. Histological serial sections of 6 postmortem nasal cavities showed that the high laminae of the vomer prevent any caudal dislocation of the septal cartilage.

Humans↗

PubMed1987

Lipoma of the larynx.

Two cases of intrinsic laryngeal lipoma are added to the twenty-four cases recorded previously. Lipoma may occur anywhere beneath the skin over the entire body. In the larynx these tumours lie rather deep and it is therefore important to obtain a deep tissue biopsy. It is possible to remove a substantial part of the swelling endoscopically and to relieve the patient's symptoms. We feel that lipoma of the larynx may be more common than has hitherto been reported in the literature.

Female↗