Biomedical subjects

A P Soisson

Publications and source records attributed to A P Soisson.

25 records · Page 2Linked to original sources

PubMed1989

Reactivity of epidermal growth factor receptor monoclonal antibodies with human uterine tissues.

Two monoclonal antibodies (29.1 and 528), which were raised against the epidermal growth factor receptor, were used to evaluate expression of epidermal growth factor receptor in frozen uterine tissue with immunohistochemical techniques. Monoclonal antibody 29.1 stained only vascular endothelium and glandular epithelium in patients who were blood type A. This staining pattern is consistent with the previously reported blood type A specificity of this antibody. Monoclonal antibody 528, which recognizes a peptide determinant is thought to be specific for the epidermal growth factor receptor, stained both endometrial glands and endometrial stromal cells heavily. Faint staining was also seen in myometrium in most cases. This marked difference in expression of epidermal growth factor receptor between endometrium and myometrium contrasts with results of prior biochemical studies in which tissue homogenates were used. No variation in intensity of staining was seen between proliferative and secretory endometrium with the use of either antibody.

ABO Blood-Group System↗

PubMed1988

Estimated weight of the term fetus. Accuracy of ultrasound vs. clinical examination.

A prospective analysis was done of the accuracy of fetal weight estimation comparing clinical and ultrasound estimation with actual birth weight in 100 women at term. The mean error of clinical estimation was 277 g, or 79.4 g/kg, for a 7.9% error. The error of ultrasound in the same population was 286 g, or 81.7 g/kg, for an 8.2% error. Analysis of these data revealed no statistical difference between clinical estimation and ultrasound estimation of birth weight in the term fetus, even at the extremes of birth weight.

Birth Weight↗

PubMed1988

Endocervical curettage in the evaluation of cervical disease in patients with adequate colposcopy.

The purpose of this study was to investigate the importance of endocervical curettage in the outpatient management of women with cervical neoplasia. From 1975-1985, 1500 patients were evaluated in our colposcopy clinic. Endocervical curettage was done routinely, even when colposcopy was adequate; 122 patients with abnormal cytology, an adequate colposcopic examination, and dysplastic epithelium in the endocervical curettings underwent conization. Of these 122 patients, 111 (91%) had cervical intraepithelial neoplasia on cone, one had microinvasion, and none had invasive cancer. In this group, there were 11 patients with abnormal cytology, normal coloposcopically directed biopsies of the ectocervix, and positive endocervical curettages. Nine of these 11 had dysplasia confirmed by conization, which would have been missed if endocervical curettage had not been performed.

Biopsy↗

PubMed1987

Supernumerary ovary. A case report.

To date only 13 cases of histologically confirmed supernumerary ovary have been reported. This case met Wharton's criteria and histologically represents the 14th case. The patient had undergone a transabdominal hysterectomy and bilateral salpingo-oophorectomy for chronic pelvic pain. Several years postoperatively she again presented with a complaint of pelvic pain. At surgery a mass was found on the anterior descending colon. The mass was bilobed and was projecting from beneath the taenia coli. The final pathology report revealed ovarian tissue.

Adult↗

PubMed1986

Acute pyelonephritis complicated by respiratory insufficiency. A case report.

Acute pyelonephritis is one of three clinical entities within the spectrum of urinary tract infection. It occurs commonly in pregnancy and, as recognized recently, can be associated with acute respiratory insufficiency.

Acute Disease↗

PubMed1985

Value of a screening urinalysis in pregnancy.

In order to assess the value of a screening urinalysis in the detection of urinary tract infection, the results of routine urinalyses from 1,062 obstetric patients were compared to subsequent culture results. A positive urine culture was predicted by pyuria, bacteriuria and a positive nitrite test; the predictive values were 23%, 21% and 87%, respectively. If all the parameters were negative, 96% of the cultures were negative. These findings suggest that in the interest of cost effectiveness, the urine can be cultured only when the screening urinalysis shows pyuria, bacteriuria or a positive nitrite test.

Bacteriuria↗

PubMedDate not supplied

Failure of gonadotropin releasing hormone therapy in patients with metastatic ovarian sex cord stromal tumors.

Ovarian sex cord stromal tumors are usually indolent neoplasms that are generally confined to one or both ovaries at the time of diagnosis. The overall prognosis for these women is good though advanced or recurrent tumors occasionally occur. In such instances, if the tumor is localized, surgical or radiation therapy often provides good results; however, diffuse intra-abdominal disease is uncommon and difficult to treat effectively. Recently, synthetic gonadotropin releasing hormone (GnRH) analogue therapy has been advocated as an effective therapy with low toxicity. We report on 2 women whose advanced recurrent ovarian cord stromal tumors failed to respond to repetitive surgical, chemotherapeutic, and GnRH therapies. In these 2 cases, GnRH therapy was not successful in controlling diffuse spread of two separate gonadal stromal tumors. Systemic toxicity was minimal.

Aged↗