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Biomedical subjects

A P Tkachenko

Publications and source records attributed to A P Tkachenko.

9 recordsLinked to original sources

[The patterns of oxygen metabolism in the early posthemorrhagic period].

Investigated all links of oxygen homeostasis of patients in early period afterwards surgical stoppage gastro-intestinal bleeding and urgent intravascular volume replacement. Macrodelivery of oxygen (DO2) was reduced in two and more time in comparison with norm predominant in connection with anemia. In spite of the infringement of transport of oxygen through alveolar-capillary membrane (especially in patients with complications and death in early postoperative period), little affected of degree of hemoglobin saturation by oxygen. Despite decrease of erythrocyte zeta-potential, largely expressed in cases of lethal outcome, considerable infringement of passage through microcirculation vessels is fixed was not. The increase of degree of morbidity and anaerobic metabolism in early postoperative period was accompanied of hyperdynamic hemodynamic reaction. The increase of degree of morbidity was accompanied of increase oxygen deficit owing to infringement of oxidoreduction in fabries also.

Biological Transport↗

[The relative critical threshold of erythrocyte hemoglobin concentration in isovolemic hemodilution].

The purpose of our research was register the relative critical threshold of erythrocyte hemoglobin concentration: that criteria, on basis of which was possible to be determined, whether the parameters of red blood for maintenance of oxygen delivery are sufficient in each particular case. Have compared two groups patients afterwards surgical stoppage gastro-intestinal bleeding and urgent intravascular volume replacement; 1) hemotransfusion was accompanied decrease of concentration patient's lactate level; 2) hemotransfusion was not accompanied decrease of concentration patient's lactate level. Have generated the algorithm of indications for transfusion of homologous blood in kind pyramid, in basis are incorporated sensitive, but underspecifically symptoms: the decrease of hemoglobin concentration, especially less 6 g/dl; the decrease of oxygen pressure, degree of hemoglobin saturation with oxygen in venous blood; the increase of blood lactate level; the relative increase cardiac output for account frequency of stroke volume and/or value of stroke volume; positive "oxygen cost" of hemotransfusion.

Blood Transfusion↗

[The adaptational reactions in mild experimental craniocerebral trauma and its combination with alcoholic intoxication].

The article deals with the results of experimental study of adaptation reactions in mild craniocerebral trauma (MCCT) combined with acute alcoholic intoxication on the basis of appraisal of the dynamics of endocrine and neuromediator shifts. A stress character of these shifts was revealed. Acute alcoholic intoxication levelled the stress reaction occurring in MCCT.

Adaptation, Physiological↗