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Biomedical subjects

A P Zaev

Publications and source records attributed to A P Zaev.

At least 19 recordsLinked to original sources
PubMed1992

[The effect of anaprilin on the reaction of the sympathetic-adrenal system to graded physical loading in healthy subjects and patients with ischemic heart disease].

The specific features of responses of the sympathoadrenal system during its activation by graded exercise (E), including that along with anaprilin induced blockade of beta-adrenoceptors, were determined from the urinary excretion of norepinephrine, epinephrine, dopamine, and dioxyphenylalanine in 54 healthy males and 22 patients with postinfarction cardiosclerosis concurrent with Functional Class I-II angina pectoris on effort. E caused hyperreactivity of the sympathoadrenal system, as appeared as significantly greater increases in the levels of catecholamines and their precursors in the patients than in the healthy persons. A single anaprilin dose of 40 mg abolished the responsiveness to exercise and improved its tolerance. The revealed features of sympathoadrenal responsiveness to exercise with and without anaprilin suggest that the patients with coronary heart disease have sympathoadrenal dysfunction, which shows one of the possible mechanisms responsible for the cardioprotective effect of beta-adrenoblockers in this disease.

Adrenal Glands↗
PubMed1991

[The hemodynamic support of physical loading in patients with mitral valve prolapse].

Bicycle ergometry and echocardiographic studies were carried out in 29 patients aged 17-29 years with first revealed mitral valve prolapse (MVP) without any signs of mitral regurgitation. According to bicycle ergometry, the patients manifested changes in hemodynamics pointing to dysfunction of the cardiovascular system. Echocardiography discovered a reduction of the mass and a rise of the rate of contraction of the circular fibers of the left ventricle, evidence of the myocardial genesis of the hemodynamic changes. Comparison of the findings of bicycle ergometry and echocardiography allowed a conclusion about the necessity of the follow-up of patients with MVP in spite of the high level of threshold load and the lack of the clinical signs of heart failure.

Adolescent↗
PubMed1991

[Study of the status of energy metabolism in thyrotoxicosis by the insulin test].

The insulin test was carried out in 68 healthy subjects and 20 patients with moderate thyrotoxicosis at the stage of compensation. Blood levels of pyruvate and lactate, plasma and erythrocytic glucose, urinary catecholamines and gas exchange were measured before, 30 and 120 min after intravenous administration of insulin (0.15 U/kg). All the measurements evidenced hypermetabolism: oxygen consumption, carbonic acid production, pulmonary ventilation were enhanced; lactate-pyruvate index and urine catecholamines were lower versus those of healthy subjects. Correlation analysis demonstrated disturbed regulation of hyperventilation by the sympathetic-adrenal system in thyrotoxicosis.

Adult↗
PubMed1990

[Hemodynamics and its control in patients with thyrotoxicosis and in healthy persons according to the data of anapriline and graded exercise tests].

The study was undertaken to examine effects of anapriline on bicycle ergometric and echocardiographic parameters and catecholamine excretion in 17 patients with thyrotoxicosis and 21 healthy subjects. A single dose of anapriline contributed to transition of hyperkinetic central hemodynamics to eukinetic one and a more saving regimen of heart performance at rest and submaximal exercise levels in the healthy subjects. In contrast, the patients maintained hyperkinetic hemodynamics and had a high energy demand during exercise and showed a reduction in left ventricular systolic and diastolic function and a significant decrease in catecholamine excretion. Disintegration of regulatory mechanisms in thyrotoxicosis was found to be due to the function interrelationship between thyroid hormones and catecholamines.

Adult↗
PubMed1990

[Study of metabolic characteristics in patients with ischemic heart disease based on the insulin test].

The study was undertaken to examine 68 healthy males and 34 patients with Functional Class I coronary heart disease. The insulin test (fasting intravenous simple insulin, 0.15 U/kg body weight, was given in the morning) was performed. The study was conducted in 3 stages: 1) before, 2) 30 min, and 3) 2 hr after insulin administration. Examination of glycemia and gas exchange revealed changes resulting in impaired energy supply of the body in CHD. In CHD patients, the enhanced glucose uptake after insulin was followed by abnormalities both in aerobic and anaerobic glucose oxidation. The insulin test detected the signs of excessive overtension and diminished reserve potentialities of the sympathetic adrenal system early in CHD.

Adult↗
PubMed1989

[The role of changes in central and intracardiac hemodynamics in lowering the physical work capacity of patients with ischemic heart disease and diabetes mellitus].

The data of bicycle ergometry test and echocardiography were studied and compared in patients with postinfarction cardiosclerosis and type II diabetes mellitus without the clinical signs of heart failure. The patients showed the decreased work fitness and the identity of cardiovascular responses to graded exercise, pointing to the common character of the pathogenesis of these diseases. Both groups of the patients manifested the hyperkinetic type of the central hemodynamics as well as the lowering of the rate of diastolic relaxation and the rise of the end diastolic volume of the left ventricle. The intracardiac hemodynamics of coronary heart disease was characterized, in addition, by the reduction of myocardial contractility of the left ventricle due to focal injuries to the myocardial structures, which are more pronounced than in diabetes mellitus.

Adult↗
PubMed1989

[Characteristics of hormonal regulation in patients with ischemic heart disease after the insulin test combined with physical load].

Nine normal subjects and 6 coronary patients (aged 26 to 53 years) who had survived myocardial infarction more than 3 years before and showed no clinical signs of heart failure, obesity, hypertension and diabetes mellitus, while having normal glucose tolerance test values, were exposed to the insulin test in combination with physical stress in the presence of clinically manifest hypoglycemia. Plasma and erythrocyte glucose and immunoreactive insulin, and urinary excretion of catecholamines were measured. Coronary patients showed considerably increased erythrocyte immunoreactive insulin levels, recorded immediately upon discontinuation of exercise, while their sympathoadrenal hormonal activation was less significant, as compared to normal subjects. The combination of the insulin test and exercise in coronary patients with normal glucose tolerance values helps to detect disturbances of regulatory mechanisms at the erythrocyte level and can be used as an adjuvant method for the assessment of latent carbohydrate metabolic disorders.

Adult↗
PubMed1988

[Hemodynamic mechanisms of the decrease in physical work capacity in hypothyroidism and thyrotoxicosis].

A study of 21 patients with hypothyroidism, 22 patients with thyrotoxicosis and 18 normal subjects, using echocardiography and bicycle ergometry, demonstrated different mechanisms of reduced working capacity, associated with those conditions. The decrease in chronotropic and inotropic heart reserve, associated with hypothyroidism, is shown to be rooted in slowed-down relaxation of left ventricular posterior wall in the presence of diastolic arterial hypertension, while limited working capacity, associated with thyrotoxicosis, is rooted in resting myocardial hyperfunction due to hyperkinetic circulation.

Adult↗
PubMed1988

[Functional status of the myocardium in thyrotoxicosis].

Twenty-two patients with thyrotoxicosis, showing no clinical signs of heart failure were examined electro- and echocardiographically. Bicycle ergometry was also used in 13 of those. Central and intracardiac hemodynamics were assessed at rest, as was cardiovascular response to exercise. The results were compared to similar parameters in 18 normal subjects. Echocardiography demonstrated hyperkinetic circulation and normal myocardial contractility in the resting patients. Bicycle ergometry showed considerably limited working capacity in those patients. Limited chronotropic and inotropic reserve of the heart in the presence of increased left-ventricular operation at rest may be pathogenetically involved in reduced stress tolerance, seen in patients with thyrotoxicosis.

Adult↗
PubMed1987

[Tolerance of the cardiovascular system of hypothyroidism patients for physical loading].

Twenty-one patients with primary hypothyroidism were subjected to electro- and echocardiography, and 10 patients, to bicycle ergometry, to examine their central and intracardiac hemodynamics at rest and cardiovascular response to exercise. The results were compared with the respective parameters of 18 normal subjects. Hypothyroidism was shown to be associated with increased left-ventricular myocardial weight (echocardiographic evidence in the presence of normal myocardial contractility at rest, lowered stress tolerance due to a smaller chronotropic reserve of the heart, and myocardial metabolic disorders.

Adult↗
PubMedDate not supplied

[Physical working capacity and myocardial perfusion in patients with diabetes mellitus].

A study was made of the interrelationship of myocardial perfusion with physical working capacity in different types of DM (with the duration of disease from 4 to 8 years without clinical signs of circulatory insufficiency). Rated physical exercise testing in 12 patients with insulin dependent diabetes and 27 patients with noninsulin dependent diabetes as well as in 40 healthy subjects has shown a GTT decrease in diabetes mellitus irrespective of patient's age, sex and body mass to be more marked in noninsulin dependent type and to be closely related to disturbed oxygen supply of the heart and a lowered myocardial reserve. Bicycle ergometric testing combined with 201Tl scintigraphy in 20 patients has shown disorder of perfusion in all the patients irrespective of a diabetes type and duration of disease. Insulin dependent diabetes mellitus was characterized by stable perfusion defects resulting from metabolic derangements, and noninsulin dependent diabetes mellitus was characterized by a decrease in the level of a maximum Tl uptake by the myocardium and transient perfusion defects of ischemic type.

Adult↗