Biomedical subjects

A Pachaï

Publications and source records attributed to A Pachaï.

4 recordsLinked to original sources

PubMed2000

Complement activation reaches maximum during equilibrium between antigen and antibody in an in vitro model for thrombolysis with streptokinase.

Treatment with streptokinase (SK) of patients with acute myocardial infarction (AMI) is known to activate the complement system. In a previous investigation we found a great variation in the degree of complement activation taking place during infusion of SK in patients with AMI (range: 0-293% increase in pretreatment complement split product 3d (C3d) levels). In this in vitro study we added SK to serum with different concentrations of SK-antibodies (SK-Ab) and found that both the relative concentrations and the total concentrations of SK and Ab determined the degree of complement activation elicited by SK. This finding was in accordance with the Kendall-Heidelberger equation of antigen-antibody equivalence. Furthermore, we found parallel rises in C3d and C4d, indicating that complement was activated via the classical pathway. A condition for maximal complement activation is antigen-antibody equivalence.

Antigen-Antibody Reactions↗

PubMed1998

[Peroral drug administration to children--are there any problems?].

Children's compliance with orally administered medicine is described. Five hundred questionnaires were given to the parents of children at their first visit at the out-patient clinic with a response from 484. Three hundred and ninety-seven children had been treated with oral medication in the form of liquid formulation or tablets, 257 within the previous year. Of these, 43.2% reported difficulties in taking the medication. Only 8.5% of the treatments had been interrupted. The main cause of the problems were the medications' taste and difficulties with swallowing tablets. The problems were more pronounced among the younger children. The administration of tablets was more difficult than the administration of liquids. There was no relationship between the problems and frequency of dosing, duration of treatment, severity of illness, social status of the parents, or the parents' age. In conclusion, prescription of better tasting mixtures and chewable tablets may reduce the problems associated with administering oral medication to children.

Administration, Oral↗

PubMed1997

[Guidewire knot formation during insertion of a central venous catheter].

A knot was formed on the guidewire during the procedure of inserting a central venous catheter through the right subclavian vein. The diameter of the knot was 3 mm after it had been pulled as tight as possible. Fortunately, there was no sign of severe haemothorax, though the knot must have caused considerable damage to the vessel.

Catheterization, Central Venous↗

PubMed1997

Streptokinase, complement activation and hypotension.

The purpose of this study was to establish whether complement activation is the cause of transient hypotension during streptokinase infusion in patients with acute myocardial infarction. Thirteen patients with suspected acute myocardial infarction and treated with streptokinase were included. Complement 3d (C3d) as an indicator of complement activation was assessed in venous blood and blood pressure was measured. Ten patients had verified myocardial infarction. Three patients did not. Five patients developed an increase in C3d blood levels of more than 200% within 30 min. All patients developed a transient fall in blood pressure during infusion of streptokinase. This was related neither to presence of myocardial infarction nor to degree of complement activation. The mechanism of hypotension observed following the administration of streptokinase is not through complement activation, and thus how streptokinase induces hypotension is still obscure.

Acute Disease↗