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Publications and source records attributed to A Pages.

At least 37 records · Page 2Linked to original sources
PubMed1986

Distribution of the Mr 52,000 estrogen-regulated protein in benign breast diseases and other tissues by immunohistochemistry.

A secreted glycoprotein with a molecular weight of 52,000 is induced by estrogen in breast cancer cells and has been purified to prepare monoclonal antibodies. The protein has been detected in some breast cancers but not in normal breast and uterus. In order to study its potential value as a marker, we have tested by immunohistochemistry frozen sections of several normal and malignant tissues and of benign mastopathies. Among different tissues tested, the Mr 52,000 protein was detected only in liver, sweat glands, and some sebaceous glands, and in malignant melanomas and some breast tumors. Other estrogen-responsive tissues (ovary, placenta, endometrium, etc.) gave negative results. Immunoradiometric assay of the Mr 52,000 protein in biological fluid revealed an elevated concentration in cyst fluid (0.5 to 7.4 micrograms/ml), pleural effusions of certain metastatic breast cancer, and sweat. By immunohistochemistry, the Mr 52,000 antigen was also detected in 42% of 129 benign mastopathies. Gynecomastia, fibrous disease, fibroadenoma, and adenosis were mainly negative, whereas ductal hyperplasia and cysts were positive. The Mr 52,000 protein was found mostly in proliferative ducts and in cysts but not in lobular hyperplasia and nonproliferative lesions without cyst. More Mr 52,000 protein was found in postmenopausal patients than in premenopausal patients. We conclude that the Mr 52,000 protein is a marker associated with mammary cysts and proliferative ducts. On the basis of the increased risk of breast cancer in proliferative mastopathies, we suggest that the Mr 52,000 protein is useful for predicting high-risk mastopathies acting as a marker associated with the proliferation of ductal tissue.

Age Factors↗
PubMed1986

[Primary cervico-facial amylosis. Apropos of a case].

Diagnosis in a case of primary localized amylosis of the sinuses and cervical nodes was from the discovery of nasal obstruction with conductive hearing loss and cervical nodes. Biopsy confirmed the presence of amyloid deposits in the maxillary sinuses mucosa and the cervical nodes. This case illustrates the value of typing of the amylosis, rectal biopsy and investigation to detect a myeloma, thus providing confirmation of a primary localized amylosis. A literature review confirmed the rarity of this localization of amyloidosis.

Adult↗
PubMed1985

Dithiocarbamates in heavy metal poisoning: complexes of N,N-di(2-hidroxyethyl)dithiocarbamate with Zn(II), Cd(II), Hg(II), CH3Hg(II), and C6H5Hg(II).

The complexes M(DHDC)2, CH3Hg(DHDC), and C6H5Hg(DHDC) (M = Zn, Cd, Hg; DHDC = N,N-di(2-hydroxyethyl)dithiocarbamate) were prepared and investigated in solution and in the solid state by using 1H and 13C NMR, ir, and Raman spectroscopy. The dithiocarbamate group is anisobidentate and the complexes are associated in solution and the solid state via hydrogen bonding. The possible relation of these structural properties to the behavior of DHDC in the treatment of cadmium poisoning is discussed.

Cadmium↗
PubMed1985

Carcinoid tumors of the larynx. A case study.

Carcinoid tumors of the larynx are very rare: only 11 cases have been described in the available literature. We report another case, and discuss the nature of the cells of origin and the relationship between these tumors and another rare laryngeal tumor, the oat cell carcinoma.

Aged↗
PubMed1984

[Congenital vascular tumor of the larynx: cellular hemangioma].

A 9 year old child was operated upon for a very vascular tumor of the right piriform sinus, signs of which had been present at birth. Histopathologic and ultrastructural examinations showed the lesion to be composed of both endothelial and pericytic elements, suggesting the diagnosis of a cellular hemangioma. This tumoral variety, particularly rare in the larynx, has been distinguished from the group of hemangiopericytomas described by Stout and Murray, not only by its usual congenital character and course but also by its specific structure.

Child↗
PubMed1983

[Carcinoid tumor of the larynx. Ultrastructural and immunofluorescence study].

Report of a 54 year-old man with a carcinoid tumor in the larynx and cervical lymph node metastasis. This left sided and dum-bell shaped tumor was spreading from the vocal cord to the piriform sinus. It was smooth, reddish and rubbery. Microscopic study showed, near by the mucosa, the tumor cells arranged in a trabecular pattern, but more disseminated and infiltrating in the deepness. Grimelius stain was positive, Masson Fontana stain negative. Electron microscopy showed neuro-secretory type granules. Immuno-histo-chemical study revealed irregularly scattered cells which were positive for ACTH, but negative for somatostatin, calcitonin and gastrin. Review of literature for this extremely rare tumor.

Carcinoid Tumor↗
PubMed1983

[Proliferative myositis, a muscular pseudo-sarcoma. Apropos of a case with an ultrastructural study].

A 40-year old woman with a history of rapidly growing tumor of the brachio-radialis muscle is described. By light microscopy, the tumor had typical features of proliferative myositis, with alternating areas of well preserved muscular fibres and strands of proliferating spindle shaped cells and ganglion like cells. Electron microscopic study showed non specific degenerative muscle changes, fibroblasts and giant cells. The histogenesis and the nosologic place of proliferative myositis are discussed.

Adult↗
PubMed1982

[Haemorrhagic necrosis of a pituitary adenoma in a case of multiple endocrine neoplasia (author's transl)].

A case of pituitary adenoma in a 55 years old man was revealed by sudden pituitary apoplexy due to haemorragic necrosis of the tumor. Neurological signs were intracranial hypertension, epistaxis and evolutive bilateral ophtalmoplegia. Case history revealed a multiple endocrine neoplasia including a pancreatic insuloma and a parathyroïd adenoma. Biological data were hypercalcemia, hypophosphoremia and elevated serum levels of prolactine and parathormone. The characteristic features of pituitary haemorragic necrosis and multiple endocrine neoplasia are reviewed.

Hemorrhage↗
PubMed1981

[Central core disease. Two cases with histoenzymology, electron microscopy and review of the literature (author's transl)].

Central axis myopathy is one of the commonest congenital myopathies. It is transmitted above all by a dominant autosomal mode, but sporadic cases are numerous. Clinically, it is characterised by neonatal hypotonicity, delayed slow motor development in the young child, but the diagnosis may be mode only in adult life. There is preferential involvement of the muscles of the pelvis girdle, muscle wasting otherwise remaining moderate in general. Various skeletal malformation are fairly often present in association. the electromyogram is of myogenic type. The disorder does not show any marked progression. By light microscopy, the central axis is more clearly seen by stains such as PAS, trichromes, and haematoxylin phospho-tungstic. In most cases it is the sole finding and is seen in a variable number of fibres, not only from one patient to another, but from one muscle to another. The rest of the fibre may be normal or show various lesions with no specific characteristics. Histoenzymology may show rarefaction or disappearance of the II fibres, relative hypotrophy of I or II fibres, or the absence of any oxidative phosphorylase activity in the central axis. The latter shows changes with regard to ATPase activity ("structured core" and "non-structured core"). Electron microscopy shows changes in varying degree in the axis, possibly to the extent of myofibrillary destruction, contrasting with the absence of or only slight changes in the rest of the fibre. Two cases, one in a child and the other in a 24-year-old woman, are reported, illustrating the above findings. Various interpretations have been suggested for this condition. Certain authors accept the existence of progressive transformation of the II fibres, whilst others describe pathology of the Z striae or a disturbance in the distribution of the mitochondria. Similarities with other muscular lesions, in particular rod myopathy, have been envisaged.

Adolescent↗
PubMed1976

[Localized hemangioma of the bronchial trunk of the left lung in a 2-month-old infant].

A 2 month-old infant was admitted because of respiratory distress and thoracic assymetry. X-ray films revealed a distension of the left lung. A pneumo-angiography showed a cardiac silhouette displaced to the right and a normal vascular tree of the left lung. The rapid impairement of the clinical picture led to an exploratory thoracotomy. A tumor at the level of the left hyparterial bronchus was found. The histologic characteristics of the tumor were those of a hemangioma. Within the spectrum of broncheal tumors, hemangioma belong to benign mesenchymatous tumors and have a good prognosis providing that their removal is complete.

Airway Obstruction↗