Biomedical subjects

A Pajot

Publications and source records attributed to A Pajot.

9 recordsLinked to original sources

PubMed2006

Primary and memory T cell responses induced by hepatitis C virus multiepitope long peptides.

To develop a vaccine against hepatitis C virus, we synthesized four long peptides from nonstructural proteins NS3, NS4 and NS5B containing HLA-class I and class II epitopes mainly inducing responses in natural infection. In HLA-A2.1 transgenic mice, the four peptides primed higher CTL responses to 6:7 minimal HLA-A2 epitopes than those induced by the minimal epitopes. HLA-A2.1/HLA-DR1 transgenic mice immunized with one peptide, containing a class II epitope implicated in viral resolution, developed IFNgamma-producing CD4+-T and CD8+-T cells. These peptides recalled HCV-specific IFNgamma-producing cells from HCV-infected patients' PBMC. This support the selection of these domains for inclusion in a vaccine formulation.

Adult↗

PubMed1986

[47-year course of severe lymphedema of the right lower limb. 6 successive operations from 1941 to 1950. Satisfactory condition 36 years after the last operation].

Mrs. T... (born in 1920) consulted Pr R. Leriche in 1941 for severe lymphoedema of the right leg present since 1939 following fly bites. Elastic contention was insufficient. Lumbar sympathectomy performed in 1941, subcutaneous-aponeurotic resections of the lateral aspect of the leg in 1942, extended in 1946 (R. Leriche) and completed by a wide excision of the posterior aspect in 1948 (Pr Goinard, Alger) only provided temporary improvements. In 1949, five polyethylene tubes were inserted under the skin of the calf at the root of the thigh (Kunlin and Boely). Three catheters had to be removed after several months because of the risk of cutaneous perforation and secondary infection. In 1950, in view of the inadequate results, ten nylon threads were inserted into the subcutaneous tissue from the ankle to the lower abdominal wall and a very extensive resection of the subcutaneous tissue (to the level of the dermis) and the aponeurosis was performed on the medial aspect of the leg (K. and B.). A dramatic improvement was obtained, which persisted until the beginning of 1986, i. e. 36 years after this last operation. Unfortunately, oedema has gradually appeared in the other leg over the last 4 to 5 years. Despite the various treatments attempted, the volume of this leg is now greater than that of the operated leg and is associated with increasing discomfort for the patient (Table of measurements). A calcified sheath has formed around the two remaining polyethylene tubes.

Adipose Tissue↗

PubMed1980

[Plea for better terminology in surgery of the profunda femoris artery (author's transl)].

Surgical publications on the profunda femoris artery rarely give information on the site of the operation and the technic used. Experience of 356 operations carried out from 1949 to 1978 by the authors and anatomical dissection of 100 profunda femoris arteries is reported. They suggest the elimination of all imprecise terms at present attached to these operations and their replacement by a more lengthy but more understandable vocabulary, together with an attempt to classify the profunda femoris artery in two groups and its nomenclature in 4 segments, more adaptable to surgery of this artery.

Aged↗

PubMed1968