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Biomedical subjects

A Palmer

Publications and source records attributed to A Palmer.

At least 145 records · Page 8Linked to original sources
PubMed1984

Some otological differences between pigmented and albino-type guinea pigs.

Cochlear action potential thresholds across frequency (AP audiograms) and AP tuning curves were compared in albino (Dunkin-Hartley) guinea pigs and normal pigmented animals. AP audiograms were very similar; on average the albinos had AP thresholds 2-3 dB lower at 2 kHz and below compared with the pigmented guinea pig. AP tuning curves at 16 kHz were, on average, significantly less sharply tuned in the albino, but similar at 8, 4, and 2 kHz. Although we find only small differences in these measures of normal cochlear function, other evidence in the literature suggests that in auditory research the use of "albino" guinea pigs is best avoided.

Animals↗
PubMed1983

Expression of Thy-1 antigen on human melanoma cells.

The expression of Thy-1 was examined on fresh frozen sections of melanoma and control skin lesions using a monoclonal antibody to Thy-1 and immunoperoxidase-labelled second antibodies. Thy-1 was detected on 12 of 19 primary melanomas but on only 1 of 23 melanoma metastases in lymph nodes, skin or brain. Expression of Thy-1 did not appear related to other known histological features of primary melanoma. Thy-1 was also expressed on 2 of 7 naevi but not on normal melanocytes or carcinoma of squamous cells, basal cells and sweat glands of the skin. Some lymphocytes below primary melanomas were Thy-1 positive. These results suggest that Thy-1 may be a marker of melanocytes at certain stages of differentiation analogous to its expression on cell lineages in the haemopoietic system. The relative paucity of Thy-1 on metastases may indicate that its expression on melanoma cells has prognostic significance for behaviour of the tumour in its host.

Adult↗
PubMed1979

The principles of tomographic positioning with particular reference to skull tomography.

Because the principles of tomography relating to positioning have not been clearly understood it has generally been the practice to employ only basic positions when undertaking tomographic studies. The purpose of this paper is to outline tomographic positioning principles, and to integrate them in a simple positioning system for common usage. This has given rise to the need for a completely new set of technical terms which pertain to positioning for skull tomography. It is hoped to establish an understanding which will enable the radiographer to devise methods of demonstrating structures for which there are no text book references to act as a guide, and to assist the radiologist in the recognition of pseudo-shadows.

Ear, External↗
PubMed1978

Byssinosis and chronic respiratory disease in U.S. cotton gins.

A pilot study of cotton gin workers was undertaken in the ginning industry so as to determine if a definitive study could be undertaken and to make some first order estimates of byssinosis and chronic respiratory disease and to compare the findings to those reported in the African and European gins. Baseline medical data were collected on 203 gin workers and 260 controls, consisting of a medical symptom questionnaire, a chest x-ray and the forced expiratory spirogram pulmonary test. Results revealed a prevalence of functional reactors equal to that found in the textile industry and other gin studies (44%) as determined by spirometric testing, without any association to smoking history. The major reaction group within the ginning population was those working in the baling press area. These same workers demonstrated evidence of chronic depressions in their spirometry data. No excess of chronic respiratory disease as determined by the questionnaire was detected within the gin worker population.

Byssinosis↗
PubMed1978

Colposcopic examination of the cervix of cebus monkeys.

A total of 410 colposcopic examinations were performed on 188 female cebus monkeys that were under study to determine the oncogenic potential of herpes simplex virus type 2 in this genus. A split-cone vaginal speculum was developed that permitted good observation of the vaginal cervix in the cebus monkey. The cervical anatomy of cebus monkeys was found to differ from that of humans in that the surface of the animal cervix was more papilliform, with thinner squamous epithelium, and the squamocolumnar junction lay within the endocervical canal. Therefore, the ability to detect abnormalities in the cervical epithelium by colposcopic examination in the cebus monkey was restricted to vascular changes in the squamous epithelium. After 100 examinations, several vascular patterns were distinguishable and interpretations of these patterns were compared with cytologic findings on the same animals. Findings by both cytology and colposcopy were mild in nature; no carcinoma was detected. Colposcopic and cytologic findings correlated at a level of 84%. More abnormalities were detected with colposcopy than with use of cytologic techniques.

Animals↗
PubMed1978

The prevalence and clinical diagnosis of vaginal candidosis in non-pregnant patients with vaginal discharge and pruritus vulvae.

Two hundred and thirteen nonpregnant female patients complaining of vaginal discharge or pruritus vulvae were recruited to the study by 45 general practitioners in the Yorkshire region. Of these patients, 102 (48 per cent) were found to have demonstrable vaginal mycosis on an initial swab and a further 10 to be swab positive after one week of placebo treatment. The total prevalence in this population of women consulting their practitioner was thus 52.6 per cent.Analysis of symptomatology and of physical findings showed that a clinical diagnosis of vaginal mycosis cannot be made with acceptable reliability.The occurrence of spontaneous swab conversion is noted, and its possible origins are discussed.

Female↗
PubMed1977

Phenylalanine inhibited p-nitrophenyl phosphatase activity in the serum as an indication of intestinal cellular disruption in the horse.

Examination of tissues obtained from thoroughbred horses showed that the 'intestinal' phosphatase activity could be differentiated from other phosphatases by analysis at a pH of 9-5 and inhibition with 15 mM L-phenylalanine. A simple method for the measurement of 'intestinal' phosphatase in heparinised plasma or serum is described. Application of the technique to serum or plasma from normal and diseased horses indicates that the increase in the activity of 'intestinal' phosphatase is associated with cases showing clinical, biochemical and haematological evidence of intestinal damage.

4-Nitrophenylphosphatase↗
PubMed1976

A critical review of intrauterine fetal transfusion.

A critical review of 142 intrauterine fetal transfusions performed in 99 patients during 107 pregnancies raised doubts about the absolute benefit of the procedure. Two main problems emerged: the diagnostic criteria upon which decisions were based were inadequate and the fetal mortality associated with transfusion was high, especially when this was performed before 28 weeks. We measured amniotic fluid bilirubin concentration by a biochemical method but the results following intrauterine fetal transfusion were similar to those observed by others using spectrophotometric examination of amniotic fluid.

Abortion, Spontaneous↗
PubMed1975

Vaginitis.

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Adult↗