PubMed Health⌕ Search

Biomedical subjects

A Parodi

Publications and source records attributed to A Parodi.

At least 37 records · Page 2Linked to original sources
PubMed1996

Mossy leg with eccrine syringofibroadenomatous hyperplasia resembling multiple eccrine syringofibroadenoma.

Eccrine syringofibroadenoma (ES) is a histological entity with a polymorphous clinical presentation. We describe a patient who had multiple nodules on both of his legs resembling lymphoedematous keratoderma (mossy leg or elephantiasis) in the absence of any vascular or lymphatic incompetence. The histological features were those of ES. A surgical resection was effective. Our case is probably an eccrine sweat duct reactive hyperplasia rather than a neoplasia or hamartoma.

Adenoma, Sweat Gland↗
PubMed1995

Persistent erythema multiforme: report of two new cases and review of literature.

Within the clinical spectrum of erythema multiforme, two subgroups have been recently identified: recurrent erythema multiforme and the rare persistent erythema multiforme. Two additional cases of persistent erythema multiforme are described. Lesions were widespread and resistant to traditional therapies. One of the patients had an underlying malignancy; the other exhibited a symptom complex characterized by fatigue, fever, sore throat and lymphadenopathy, and an abnormal Epstein-Barr virus serologic profile suggestive of endogenous reactivation of Epstein-Barr virus infection.

Adult↗
PubMed1995

May Helicobacter pylori be important for dermatologists?

Helicobacter pylori, a microaerophilic gram-negative bacterium, is the major cause of gastritis, plays a key role in the etiology of peptic ulcer and is a risk factor for gastric cancer. Although 50% of the population is affected, dermatologist seem to be unaware of the impact H. pylori may have on cutaneous pathology. Among skin diseases, H. pylori has been related so far only with chronic urticaria and rosacea. In rosacea, histology of the stomach mucosa revealed tht 84% of 31 patients were H. pylori positive. Twenty percent of them were serologically negative, but, overall, 100% of the 20 patients with both histology and serology were H. pylori positive with either test. The consistency between clinical success with metronidazole and abatement of H. pylori isolates and serology after treatment was an additional evidence suggesting an etiologic relationship between rosacea and H. pylori infection. Rosacea has often been linked with gastrointestinal disturbances. H. pylori, therefore, may link them to the well-known beneficial activity of metronidazole on rosacea lesions. The role of H. pylori is more probable in erythrotic rosacea than in its papulopustular and granulomatous stages. As in Bacillus subtilis intoxication, a flush-inducing toxin cannot be excluded. Despite the difficulty to find patients accepting bioptic gastroscopies, large case-control studies should be done before a causal relationship with urticaria and rosacea is firmly established.

Bacterial Toxins↗
PubMed1995

Antihistone antibodies in scleroderma.

BACKGROUND: Antihistone antibodies (AHA) are usually considered the serological marker of drug-induced lupus erythematosus, but recently they have been found in patients with systemic scleroderma (SSc) and morphea. OBJECTIVE AND METHODS: We determined AHA in 43 patients with SSc, 4 patients with overlap syndrome and 11 with morphea. RESULTS AND CONCLUSIONS: AHA were demonstrated in 41.8% of the SSc patients and in 36.3% of the morphea patients. Only 1 patient with overlap syndrome had AHA. Our SSc patients with AHA had frequent cardiac and renal involvements suggesting a prognostic value of AHA. In our morphea patients AHA did not correlate with clinical features.

Adult↗
PubMed1995

Lichen planus presenting with erythema-multiforme-like bullous lesions in a patient with systemic scleroderma.

A patient with systemic scleroderma is described who developed a cutaneous eruption of papules and vesicobullae. Over time, the latter turned into papules. The histopathological and immunofluorescence features of the papular lesions were unequivocally those of lichen planus, while those of the bullous lesions reminded of erythema multiforme. Histologically, erythema multiforme shares common features with lichenoid reactions, such as necrotic keratinocytes. Our case suggests that erythema multiforme and lichen planus may coexist or succeed each other as different stereotype immune reactions against the same antigen(s) within the epidermis.

Blister↗
PubMed1994

Long-term antimicrobial prophylaxis in lung cancer surgery: correlation between microbiological findings and empyema development.

This study was planned in order to determine the value of antimicrobial prophylaxis in preventing post-operative empyema in patients undergoing lung cancer surgery. Two-hundred consecutive subjects operated upon for lung cancer received teicoplanin and aztreonam, starting at the induction of anesthesia and lasting until removal of the pleural drains. Cultures for aerobic and anaerobic bacteria were taken from: (1) the bronchus at the time of surgical division; (2) the pleural space before closure of the chest; (3) the pleural fluid during the post-operative period; and (4) the tips of chest drains at the time of their removal. In the 200 patients receiving antibiotic prophylaxis, the number of post-operative empyemas (1%) was lower than that (7.5%) found in 53 comparable patients who were previously treated with placebo. In the 'placebo group', empyema was due to gram-positive bacteria, while in the 'prophylaxis group', it was caused by Gram-negative bacteria (Pseudomonas aeruginosa). A significant (P < 0.05) correlation between infected bronchial secretions, pleural space contamination at surgery, contamination of chest fluid and drains during the post-operative period, and empyema development was demonstrated. In conclusion, antibiotic prophylaxis, while being effective in preventing post-operative empyema, may induce the colonization of the respiratory tract with highly resistant gram-negative bacteria.

Aged↗
PubMed1994

Anti-GOR antibodies in lichen planus.

Anti-GOR antibodies characterize patients with autoimmune hepatitis type 2 who are all positive for antibodies to hepatitis C virus (HCV) and have low titers of anti-liver/kidney-microsomal (LKM1) antibody. The documented prevalence of anti-HCV antibodies in patients with lichen planus (LP) and chronic liver disease (CLD) and their negativity for anti-LKM1 antibodies make them eligible for having anti-GOR antibodies. We studied such a possibility in 56 LP patients. Twenty of them had also CLD. Seven CLD patients without LP served as control. Overall, 11/63 patients had anti-GOR antibodies. All of them were anti-HCV positive and had CLD. CLD patients with LP showed the same prevalence of anti-GOR antibodies as CLD patients without LP.

Adult↗
PubMed1994

[Neuroendocrine response in surgery: comparison between inhalation anesthesia (isoflurane) and intravenous anesthesia (propofol)].

The objectives of the study: 1) comparison between the two anesthesiological techniques both of which were applied to the various surgical groups (patients undergoing emergency surgery for abdominal pathologies and patients undergoing bone marrow biopsy); 2) a comparison between pre- and intraoperative stress levels. The experimental design consists of a comparative survey aimed at ascertaining the existence of statistically significant differences in pre- and intraoperative hormone levels (objective 1) and differences in hormone profiles depending on the anesthesiological technique used (objective 2). Patients were artificially ventilated; intraoperative monitoring included: automatic non-invasive AP every 3 minutes; cardiac monitoring; ETCO2; SaO2; all patients showed a normal postoperative evolution. A total of 30 patients were included in the study (mean age 34 years; ASA 1-3) 14 of which underwent bone marrow biopsy and 16 emergency surgery for abdominal pathologies; patients with hormonal pathologies or receiving treatment with drugs capable of influencing hormone response were excluded from the study.

Adrenocorticotropic Hormone↗
PubMed1993

Cancer research in the European Community and other non-EC countries.

AIMS: We assessed the scientific productivity in the field of cancer research of countries in the European Community (EC) and the most important non-EC countries by counting the number of papers published during the period 1988-1990 in 15 of the top scientific journals (as defined by the Journal Citation Reports, Oncology). The global and per capita data are presented for each country. METHODS: Qualitative parameters like the impact factor and the half-life were also considered in the analysis. The selection of cancer journals with a high average quotation rate gave significant results. Introducing the average impact factor and half-life of each journal modified the results only slightly. The per capita data for each country were not corrected for the number of investigators working in oncology (a datum difficult to obtain). The parameters thus do not define the performance of the average investigator but are more "economic" parameters specifically related to the field of cancer research. RESULTS AND CONCLUSIONS: Small, wealthy Western countries tended to have an advantage over large, less developed countries, as expected. However, additional individual differences that could be of interest were present in the group of developed countries.

Canada↗