A Pasagian | PubMed Health

PubMed1988

Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling.

Proteins undergo a series of nonenzymatic reactions with glucose over time to form advanced glycosylation end products (AGEs). Macrophages have a receptor that recognizes the AGE moiety and mediates the uptake and degradation of AGE proteins. This removal process is associated with the production and secretion of cachectin (tumor necrosis factor) and interleukin-1, two cytokines with diverse and seemingly paradoxical biological activities. The localized release and action of these cytokines could account for the coordinated removal and replacement of senescent extracellular matrix components in normal tissue homeostasis.

Glycosylation↗

PubMed1985

Genotypic variation in age-related changes in peripheral catecholamines.

The effects of aging on catecholamine concentrations in heart ventricle, aorta, and adrenal gland were evaluated in two inbred mouse strains (C57BL/6J and DBA/2J) and an F1 hybrid (B6D2F1). The effects of aging on ventricular norepinephrine (NE) levels were found to be strain specific; only the C57BL/6J strain showed a significant decline in ventricular NE levels with age. Though all strains showed a decline in ventricular epinephrine (EPI) levels with age, the magnitude of the decrease varied between strains. An age-related increase in ventricular dopamine (DA) levels was observed in each of the strains. Although strain differences in catecholamine levels were also observed in aorta and adrenal gland, no age-related changes in catecholamine concentrations were noted in any of the strains. The findings indicate strain and organ specific changes in the effects of aging on catecholamine concentrations in peripheral organs.

Adrenal Glands↗