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A Pasco-Papon

Publications and source records attributed to A Pasco-Papon.

11 recordsLinked to original sources
PubMed2006

[MRI aspects of anoxic-ischemic encephalopathy of the term and premature newborn].

These past few years have seen an increasing role of MRI in the investigation of neonatal cerebral anoxic-ischemic pathology. This is due not only to greater precision in diagnosing lesion extension, but also to earlier detection of lesions with the diffusion of weighted imagery. The aim of this iconographic review is to illustrate the main MRI aspects of anoxic-ischemic encephalopathy in a pedagogical way. After a brief physiopathology reminder, the different cerebral lesions are studied in a first chapter on the premature newborn pathology and a second chapter on full-term newborn pathology.

Age Factors↗
PubMed2005

[Conventional and diffusion magnetic resonance imaging in the acute phase of severe traumatic brain injury].

Neuro-imaging is essential for the initial evaluation and subsequent control in the acute stage of severe head injury. In these indications tomodensitometry (TDM) has a pivotal role. Despite the well recognized contribution of magnetic resonance imaging (MRI) to the investigation of most of acute neurological pathologies, MRI is not still a routine procedure for the initial investigation of patients with acute head injury. The superiority of morphological and functional MRI on TDM in this indication is discussed.

Acute Disease↗
PubMed2005

Supratentorial primitive neuroectodermal tumours of the brain: multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients.

AIMS: To examine the clinical and pathological characteristics of supratentorial primitive neuroectodermal tumours (PNETs) in a retrospective series of 18 patients, according to the strict definition of the World Health Organization classification of tumours that excludes other types of malignant embryonal tumours of the brain. METHODS AND RESULTS: Eleven children and seven adults with supratentorial PNETs were diagnosed between 1993 and 2002 and their medical records were reviewed. An immunohistochemical study was performed on formalin-fixed paraffin-embedded tissue of 18 primary tumours and five recurrences with antibodies for neuronal (neuron specific enolase, synaptophysin, neurofilament, chromogranin A), epithelial [epithelial membrane antigen (EMA), cytokeratin], glial [glial fibrillary acidic protein (GFAP)], muscle (desmin, h-caldesmon, alpha-smooth muscle actin, myogenin) differentiation and with two anti-CD99 antibodies. All tumours showed at least one neuronal marker except chromogranin A; a variable number of cells were GFAP+ or EMA+ in 18/23 tumours. Six primary tumours and one recurrence were positive for cytokeratin and/or one muscle antigen except myogenin. CD99 was observed in 33% of the cases. The mean duration of overall survival was 20 months. The estimated overall survival rates were 61% at 1 year, 29% at 2 years, and 18% at 3 years. Two factors of poor prognosis were identified by univariate analysis: a positive cerebrospinal fluid cytology at diagnosis and the absence of complete resection. No distinct immunophenotype was statistically related to survival. CONCLUSIONS: A multidirectional differentiation is a frequent event in supratentorial PNETs but has no apparent influence on the outcome of this aggressive neoplasm.

12E7 Antigen↗
PubMed2004

Treatment of epistaxis in Rendu-Osler-Weber disease by in situ Ethibloc injections.

After a brief review of Rendu-Osler-Weber disease, we present the results from a series of 13 patients treated by Ethibloc injections for epistaxis. Based on a review of the literature, typical treatments are presented along with discussion of their efficacy and side effects. In our series, 90% of patients improved after only one injection. All patients reported a decrease in hemorrhage, especially patients with recurrent epistaxis. Five of nine patients reported a decrease in the length of the bleeding episodes. Improvement was reported by 85% of patients within one month following Ethibloc injection. Fifty percent of these patients have persistent good results at 4 Year follow-up. Our results indicate that Ethibloc injections are safe and effective as an alternative treatment for patients that have failed standard treatment options.

Adult↗
PubMed2004

[Emergency imaging of cerebrovascular accidents].

Over the last 25 years, advances in neuroimaging have significantly changed the evaluation and management of acute stroke syndromes. In the seventies, computed tomography (CT) could differentiate between ischemic and hemorrhagic stroke. Magnetic resonance imaging (MRI) is nowadays the imaging modality of choice in the initial assessment of acute stroke. MRI images can better discriminate acute, subacute and chronic infarcts, differentiate venous from arterial infarcts, detect arterial dissection, stenosis or occlusion. Diffusion-weighted images are highly sensitive and specific to acute infarction and the combination with perfusion technique is suitable to define potentially reversible ischemia (area of cerebral "mismatch" which is thought to represent the so-called ischemic penumbra). This penumbra is a potential therapeutic target of valuable interest for the treating physician.

Acute Disease↗
PubMed2001

[Trismus, pseudobulbar syndrome and cerebral deep venous thrombosis].

We report a case of cerebral deep venous thrombosis that manifested clinically by a pseudobulbar syndrome with major trismus, abnormal movements and static cerebellar syndrome. To our knowledge, only three other cases of deep cerebral venous thrombosis associated with cerebellar or pseudobulbar syndrome have been published since 1985. The relatively good prognosis in our patient could be explained by the partially intact internal cerebral veins as well as use of early anticoagulant therapy. There was a spontaneous hyperdensity of the falx cerebri and the tentorium cerebelli on the brain CT scan, an aspect highly contributive to diagnosis. This hyperdensity of the falx cerebri was found in 19 out of 22 cases of deep venous thrombosis detailed in the literature.

Cerebral Angiography↗
PubMed1999

[Post-traumatic intracranial arterial aneurysm. Two cases with review of the literature].

Post-traumatic intracranial aneurysms are rare entity, which can appear following even benign head injuries. Their clinical manifestations are various, from a typical SAH to an uncommon intracerebral hematoma. Medical history runs usually from a couple of days to several years. Two cases of intracranial aneurysm have been observed from 1995 to 1998. The first case presented as a cortical aneurysm in a cerebral contusion following a week of evolution. The second case presented as a cortical hematoma with a head trauma 10 years before. All patients were operated on with uneventful follow-up. Post-traumatic intracranial aneurysms can exhibit an increase in size or a spontaneous thrombosis. Diagnosis is made by angiography, which has to be repeated if treatment has to be delayed. Best results are obtained by exclusion of the lesion, if allowed by the patient's condition.

Adult↗
PubMed1996

[Vascular complications during surgery of lumbar disk herniation. Apropos of 3 personal cases and 37 cases from a national investigation].

Three personal cases of iatrogenic vascular complications (two arterial wounds and one arteriovenous fistula) induced by lumbar herniation surgery led to a French national investigation among vascular and neurosurgical units where 37 other such cases have been discovered over 10 years (1984-1994). In 23 cases, the initial symptomatology was collapses by arterial (22 cases) or venous (one case) hemorrhage requiring emergency vascular repair surgery; in 17 cases an arterio-venous fistula was found in a period varying from a few hours to 5 years after surgery; it was revealed by cardiac failure, lower limb edema or abdominal thrill. Among the 40 cases, 77% occurred at the L4-L5 level; the mortality was 5%, and the morbidity was 27%. Origin, causes and prevention are discussed.

Adult↗