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Biomedical subjects

A Pascotto

Publications and source records attributed to A Pascotto.

27 records · Page 2Linked to original sources
PubMedDate not supplied

Double-blind, placebo-controlled, cross-over trial of allopurinol as add-on therapy in childhood refractory epilepsy.

We report the results of a double-blind, placebo-controlled cross-over trial with allopurinol as add-on therapy in childhood refractory epilepsy. Seventeen patients received allopurinol and matched placebo for 12 weeks in 2 doses (10 mg/kg/day during the first week and 15 mg/kg/day thereafter with a washout period of 2 weeks between treatment phases. The total number of seizures was reduced by 50-98% in 4 patients (23.5%) and by 25-49% in another 4 (23.5%). However, the number of seizures remained unchanged in 5 patients (29.4%) and worsened in 4 (23.5%). Adverse side effects (17.6%) were generally mild and transient, suggesting that allopurinol is well-tolerated. A mean follow-up of 10 months of the responders did not show any relevant efficacy of allopurinol as an adjuvant therapy for refractory epilepsy, even at high doses.

Adolescent↗
PubMedDate not supplied

Neonatal hyperekplexia: a case report.

We report the case of a baby with transient generalized stiffness noticeable from the first days of life, hyperreflexia, massive jerks in response to sudden tactile and acoustic stimuli, and long-lasting myoclonic jerks closely resembling epileptic seizures. The father and paternal grandfather both had hyperekplexia. At age 3 years, the child had normal psychomotor development and persistent abnormal startle response to unexpected sounds or touch.

Cerebral Cortex↗
PubMedDate not supplied

[Epileptic crisis at the onset of SSPE (subacute sclerosing panencephalitis): considerations apropos of a case].

A case of SSPE is reported and discussed; in all the evolution of this history, epileptic seizures were precocious (a long time before the onset of characteristic features of the disease) and dominant. The Authors, also on the basis of the literature (a definite pattern of evolution of epilepsy within SSPE is not reported), emphasize that this disease must be however considered among the possible aetiologies of an epileptic syndrome with onset in childhood.

Adolescent↗
PubMedDate not supplied

[Severe mental retardation and slight dysmorphism in a child with a bisatellite extrachromosome: inversion duplication (15)?].

A de novo tetrasomy 15 has been reported, in a 6 years old child. The patient had severe mental retardation an minimal physical stigmata, consisting in slight skeletal and facial dismorphism. Cytogenetic analysis showed that extrachromosome, G-like long, was bisatellited and dicentric and was interpreted either as an inversion duplication 15 or as 15; G or D translocation.

Abnormalities, Multiple↗