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Biomedical subjects

A Patterson

Publications and source records attributed to A Patterson.

At least 91 records · Page 5Linked to original sources
PubMed1981

A membrane filtration method for estimating the number of viable bacteria in solutions containing antibiotic.

The method involves filtration of dilutions of the mixture through a membrane filter followed by replication on ox blood agar and enumeration of organisms. This method was compared with the conventional drop count method, and a significant correlation was found (r = 0.985). When solutions containing antibiotic were used, the membrane filtration method gave a more reliable estimate of the viable count at the time of sampling.

Animals↗
PubMed1978

Palate development after fetal tongue removal in cortisone-treated mice.

Morphological studies of cortisone-induced cleft palate have shown retardation in the rotation of palatine shelves from a sagittal to a transverse plane. Cortisone also reduces fetal muscular movements, which may explain why displacement of the tongue from between the palatine shelves is delayed. Previous work with extrauterine development of control fetuses demonstrated that fetal membranes and tongue were major obstacles to shelf rotation. Thus, removal of these obstacles might permit rotation and fusion of palatine shelves in cortisone-treated fetuses. In the present experiment, fetuses from cortisone-treated strain CD-1 mice were released from uterus and membranes and allowed to develop for eight hours in a fluid medium with the umbilical cord left intact. Compared to 4% fusion in utero, there was palatal fusion in 20% of fetuses released from membranes. When the fetal tongue was removed during extrauterine development, the frequency of fusions increased to 61%. Fusion appeared normal by the criteria applicable through light microscopy. Thus, cortisone induces cleft palate primarily through interference with shelf rotation. The palatine shelves of treated fetuses retain their ability to fuse when they can come in contact during the normal time for palate closure.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

Chemistry of cement burns: pathogenesis and treatment.

Two brief cases are presented describing burns resulting from exposure to cement and its components. Of particular interest is the etiology of such burns. Do they result from a high pH solution in contact with the skin under abrasive conditions for an undetermined period of time, or are they a consequence of possible allergic reactions to chromium or chromates? Another possible factor that has been largely unexplored is the role of the calcium ion--the other principal ionic species with which the skin is in contact. Much has been written about its role in membrane transport and other physiologic processes.

Adult↗
PubMedDate not supplied

Effects of low level dosing of iron on the haematology and growth rate of piglets.

Of 472 piglets (56 litters), half reeived 200 mg and half received 100 mg of iron as iron dextran administered intramuscularly as a single dose into the ham muscles between the first and fourth day after birth. The piglets were weaned at about three weeks of age, at which time those given 200 mg of iron had higher values of all haematological components. However, there was no significant difference between the mean daily live-weight gains of the two groups, and 100 mg iron maintained haematological components above levels associated with anaemia. It is suggested that 100 mg iron as iron dextran is adequate for piglets weaned at three weeks of age.

Animals↗