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Biomedical subjects

A Pavé

Publications and source records attributed to A Pavé.

6 recordsLinked to original sources
PubMed1990

Object-centered representation for species systematics and identification in living systems in nature.

An artificial intelligence application to identification in biological taxonomy is presented. An object-centered representation is described using SHIRKA, a knowledge-based system developed in France. The capacities of this system, relating to a classification algorithm, are described. An application to the identification of the trees and lianas of the evergreen forests of the Western Ghats (India) is presented to illustrate the problems encountered in the development of the knowledge base. A model of a systematist's reasoning, using evolutionary principles, is the basis of this work. Finally the efficiency of the system is discussed.

Artificial Intelligence↗
PubMed1988

[Use of an expert system as a tool to carry out urinary cyto-bacteriologic tests].

An expert system for urine examinations was developed. Its validation was performed in a routine work, by comparison of expert decisions with software conclusions. Results of finished examinations or in progress were taken into account. The agreement was satisfactory. In addition to reliability, advantages constituted by availability, flexibility and adaptability were notified. Repeatability and reproducibility were also emphasized.

Algorithms↗
PubMed1980

Codon catalog usage and the genome hypothesis.

Frequencies for each of the 61 amino acid codons have been determined in every published mRNA sequence of 50 or more codons. The frequencies are shown for each kind of genome and for each individual gene. A surprising consistency of choices exists among genes of the same or similar genomes. Thus each genome, or kind of genome, appears to possess a "system" for choosing between codons. Frameshift genes, however, have widely different choice strategies from normal genes. Our work indicates that the main factors distinguishing between mRNA sequences relate to choices among degenerate bases. These systematic third base choices can therefore be used to establish a new kind of genetic distance, which reflects differences in coding strategy. The choice patterns we find seem compatible with the idea that the genome and not the individual gene is the unit of selection. Each gene in a genome tends to conform to its species' usage of the codon catalog; this is our genome hypothesis.

Animals↗
PubMed1979

Dynamics of macromolecular populations: a mathematical model of the quantitative changes of RNA in the silkgland during the last larval instar.

The quantitative changes of RNA in the silkgland of Bombyx mori have been studied during the last larval instar by using a mathematical model (Volterra-Kostitzin model). This model can be associated with a global mechanism including synthesis and degradative processes. The numerical and statistical methods used for model analysis are described in an appendix. Thus we have compared the accumulation of total RNA (essentially ribosomal) after a treatment (juvenile hormone) and between several strains. The importance of the degradative factor is denoted to explain the observed differences, whereas the synthesis rates remain relatively stable. The last observation may lead us to an interpretation of the molecular effect of a selection to increase silk production : rather than an increase of the productivity of cellular machinery, the degradative process has been limited.

Animals↗
PubMedDate not supplied

Bacterial growth measurement using an automated system: mathematical modelling and analysis of growth kinetics.

The reliability of automated systems was assessed by simultaneously using an MS2 and a methodology of data interpretation/mathematical modelling. Two experimental situations were analysed. Bacterial growth both in synthetic and in complex media could be well described by Monod's model and the logistic model. In the two cases, the fit of the models to the data was satisfactory.

Bacteria↗