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Biomedical subjects

A Perlin

Publications and source records attributed to A Perlin.

5 recordsLinked to original sources

Single optical fibre transducer for pressure measurement.

In a single optical fibre transducer, light is injected into a fibre through a fibre optic coupler, located at some distance from the distal end of the fibre. Injected light travels toward the front face of the fibre, where it exits in the shape of a cone. then, after reflection from a reflective surface, it is readmitted into the same fibre. The reflected beam of light travels back through the coupler, exits through the distal end of the fibre and illuminates the photosensitive area of a photo diode, where it is converted to an electrical current. Depending on which one of the parameters is allowed to vary the amount of the returning light, one can build a variety of different sensors. Among them are: linear/angular displacement sensors and their derivatives such as pressure or force sensors; transmittance sensors such as turbidity and chemical sensors; reflectance sensors such as temperature sensors, optical encoders and scanners, colourometric and other types of chemical sensors. In the case of the single optic fibre transducer (SOFT) made by Pearl Instruments (Chicago, II, USA), the reflective surface is made of a thin metal foil with 6 microns thickness and 1.25 mm diameter. Optical fibres are pf the multimode type with 55 microns diameter. Their numerical aperture is equal to 0.66. The SOFT head is 1.25 mm in diameter and has an overall length of 50 cm. The disposable part of the system contains the head, fibre, protective sheathing and plug. Its operating range is -15 to +300 mmHg, and +25 to +45 degrees C, and its resolution is +/- 1 mmHg.

Computer Simulation

Temporary microvascular clips.

Selected commercially designated temporary clips (Acland, Biemer, Kleinert-Kutz, Variangle, and Yasargil) were applied for 1 hour to rat common carotid arteries. Scanning electron and light microscopic studies revealed varying degrees of endothelial damage. The authors believe that further improvements are needed in the design of temporary clips.

Animals

Shunting, release, and distribution of nine and fifteen micron spheres in myocardium.

The shunting, release, and transmural distribution of 9 and 15 mu radioactive microspheres were compared in isolated hearts and intact hearts with and without adenosine triphosphate (ATP) vasodilation. ATP vasodilation caused increase shunting of 9 mu spheres but not 15 mu spheres (p less than 0.05). The transmural distribution of 9 and 15 mu spheres in left ventricle and septum were significantly different (p less than 0.01) and the difference was characteristic for the isolated heart and the nonvasodilated intact heart. There was no difference in distribution across the right ventricle. There appear to be significant differences in regional shunting as well as distribution in the intact heart. We found no systematic correction for comparing flows measured with 9 and 15 mu spheres.

Adenosine Triphosphate