TNF-alpha serum level elevations in chronic hepatitis C patients with diabetes mellitus.
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Blood Glucose↗
Biomedical subjects
A Perrella
Publications and source records attributed to A Perrella.
CD8+/CD38+: immune activity and clinical significance in HCV patients with and without interferon therapy.
At the light of the importance of cytotoxic T lymphocyte (CTL) response during chronic hepatitis C, we carried out a study in order to evaluate the CD8+/CD38+T-cells, immunophenotypic marker of CD8+ activated cells in a selected cohort of 22 patients for four months. The patients were subdivided in two groups: A (with IFN therapy), B (without IFN therapy). The results show that in IFN-treated subjects there is a significant reduction of ALT (sign test, z = .424;p < or = .05) and that the CD8+/CD38+ present a positive correlation with HCV-RNA (r = .894; p < .05). We hypothesize that during IFN therapy the CD8+/CD38+ activity is able to oppose HCV, probably by increasing MHC I expression on the infected cells due to the IFN modulatory action, that could strengthen the immune response of CD8+ activated T-lymphocytes. These events confer the capacity to specifically respond to any viral replication and probably take part in the reduction of ALT levels by decreasing the chronic inflammation present during a defective immune response. These data show think CD8+/CD38+ marker could be a good parameter to evaluate both the viral activity and immunological status in HCV+ patients undergoing IFN treatment.
ADP-ribosyl Cyclase↗
Hepatic and peripheral T-lymphocyte patterns in patients with chronic hepatitis C infection: what correlation with histological activity?
The immunopathological processes involved in hepatic damage during chronic hepatitis C infection are not fully understood. Several works suggest the role of T helper 1 (Th1) immune response in both injury and fibrinogenesis. in this study, we have analyzed peripheral and intrahepatic T-lymphocyte subsets in liver biopsy specimens of 13 patients with definite chronic hepatitis C (CHC) to explore the possible direct role of these patterns in the evolution of necrotic inflammation and fibrogenesis scored according to the Knodell histological activity index. in particular, we have studied CD4+/CD7+ T-lymphocytes, as phenotypic marker of Th1 immune response, CD4+/CD7- as Th2 marker, and CD8+/CD38 as activated CD8+ lymphocytes. on statistical analyses we found a significant negative correlation in liver CD8+/CD38+ T-cells grading (r= -0.607; p<0.05) and staging index (r= -0.650; p<0.05) and between CD4+/CD7+ and grading (r= -0.626; p<0.05) index. in addition, we found a positive strong correlation between CD38+/CD8+ and CD4+/CD7+ T cells (r= 0.783; p<0.05) in liver tissue and between peripheral and liver resident CD8+/CD38+ (r= 683; p<0.05). moreover, the hepatic CD4+/CD7+ T-cells showed a positive correlation with peripheral CD 8+/CD38+ T-cells (r= 0.676; p<0.05). A strong positive correlation was also observed between grading and staging index (r= 0.921; p<0.01). we found no statistical correlation between the above variables and CD4+/CD7- T cells. our data could suggest that a preferential hepatic CD4+/CD7+ OR CD8+/CD38+ T cell subset was not directly associated with hepatic damage but, on the contrary, it could have been able to block liver injury. Concerning the peripheral subsets, the only CD8+/CD 38+ T-cells result reflect the CTL activity in the liver tissue. further studies are required to better understand the possible correlation between peripheral and liver resident T-helper, subset and other hepatic resident immunocompetent cells.
Journal Article↗
Immune response in the AIDS dementia complex.
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Journal Article↗
Volumetric and linear assessment of maxillary sinuses using computed tomography.
The purpose of this work was to compare linear and volumetric measurements of maxillary sinus (with and without lesion), using 3D (gold standard) and multiplanar reconstructions (MRP) by computed tomography in order to establish the precision and accuracy of these methods, determining which one would allow more effective assessments for this site. Linear measurements were performed in the maxillary sinus of 50 patients and compared with MPR and 3D images. We also analyzed the area and volume of this anatomic structure. Inter- and intra-observer average percentage errors for linear measurements were lower than 4%, the samples with lesion presenting higher values. The average error of accuracy was 4.94% for sinuses with lesion, and 7.41% for those without. We could verify that the antero-posterior and right-left measurements in axial view showed smaller figures of error when compared to sagittal and coronal reconstructions, respectively. The largest diameters observed for the sinuses had, in average, 39.6 mm in the antero-posterior direction, 28.35 mm in the right-left direction, and 36.3 mm in the supero-inferior. For the volume and area assessment, the values of error ranged lower than 9%, the highest values corresponding to the samples with lesion. The precision of measurements was inferior for maxillary sinus with lesion when compared with those without lesion. Measurements performed in the axial view were more precise than those performed in MPR images, and the coronal view measurements were considered to be more precise than the sagittal measurements.
Cephalometry↗