A Peshkovsky | PubMed Health

PubMed2003

Motion correction in MRI using an apparatus for dynamic angular position tracking (ADAPT).

Motion during MRI examinations is a serious problem that degrades the quality of the data (images) acquired. Motion can be corrected during the postprocessing of the data; however, this approach is suboptimal and is typically limited to in-plane or translational motion. An apparatus for dynamic angular position tracking (ADAPT) for prospective angular motion correction has been developed. This application is capable of "tracking" the scanned region of interest by performing dynamic adjustments of orientation of the scanning plane. The operation of the apparatus is based on deuterium MR spectroscopy and does not rely on the use of magnetic field gradients. Orientation-sensitive deuterium quadrupolar interaction in a single crystal attached to a subject is used to monitor the angular position in magnetic fields. Measurements are performed with an independent spectrometer channel in the background of the MRI scans. This apparatus is very cost- and time-efficient because it utilizes the hardware already available on many spectrometers and can be used in parallel with MRI scans. Potentially, rotations by a fraction of one degree can be easily corrected and the angular position information can be rapidly updated.

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PubMed2000

Dipolar interactions in molecules aligned by strong AC electric fields

We observed magnetization transfer and spectroscopic splittings due to dipolar couplings in the solution NMR spectra of neat nitrobenzene aligned using AC electric fields. Weak dipolar splittings have been previously observed for nitrobenzene in a DC electric field (T. M. Plantenga, et al., Chem. Phys. 66, 1-9, 1982); the use of homogeneous pulsed AC fields has allowed us to establish stable experimental conditions, which were more tolerable to sample impurities and required no sample purification, and to carry out multidimensional experiments. A pulse sequence is discussed in which the electric field is present only for the indirect dimension: this sequence records the dipolar splittings for each proton in the indirect dimension; the direct dimension presents the isotropic chemical shift. Another pulse sequence is discussed that uses the applied electric field only in the mixing period to produce cross peaks between dipolar coupled pairs and correlate their isotropic chemical shifts. The order parameter describing molecular alignment was in good agreement with that previously determined from deuterium quadrupolar measurements of deuterated nitrobenzene in a similar range of electric fields: S(mol) approximately 0.025% for a field strength of 7.0 MV/m (rms). The dipolar splittings for ortho-meta, meta-para, and ortho-para protons were in qualitative agreement with the known geometry. Copyright 2000 Academic Press.

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