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Biomedical subjects

A Petraglia

Publications and source records attributed to A Petraglia.

11 recordsLinked to original sources
PubMed1992

Bronchodilation and beta 2-selectivity of broxaterol in asthmatics: a crossover, single-blind, terbutaline- and placebo-controlled study.

To investigate the beta 2-receptor selectivity of a new beta 2-adrenoceptor agonist, broxaterol, we compared the respiratory and cardiovascular effects of this compound with those of terbutaline and placebo. Twelve asthmatic patients were evaluated in a randomized, single blind, crossover study. A single dose of each study treatment (broxaterol 400 micrograms and terbutaline 500 micrograms was administered with metered dose inhalers. Measurements of lung function (vital capacity, forced expiratory volume in one second, airway resistance and specific airway conductance), heart rate and systolic/diastolic blood pressure were performed before and at 15, 30, 60, 120, 240 and 360 min after each study treatment. No significant difference was observed between broxaterol and terbutaline in VC, FEV1 and Raw changes, although a greater and significant increase in sGaw was found only with broxaterol. Significant increases in heart rate and systolic blood pressure were observed only with terbutaline. The results of this study suggest that broxaterol can promote a greater bronchodilator effect with less cardiovascular side effects than terbutaline, probably through a greater beta 2-receptor selectivity.

Adrenergic beta-Agonists↗
PubMed1979

[Treatment of chronic respiratory insufficiency of pulmonary origin. Clinical considerations].

The key-points of the physiopathological treatment of chronic pneumogenous respiratory insufficiency are: correction of distribution defects, suitable local adjustment of the ventilation: perfusion ratio, and correction of obstacles to alveolocapillary diffusion. Many drugs can be used to obtain these results; bronchodilators, vasoactive drugs, cortisones, cardiokinetics, antibiotics, analeptics. Reference is also made to oxygen therapy, depletion management (bloodletting and-or diuretics, and their possible mechanisms. Lastly, attention is given to disturbances, in acid-base equilibrium in chronic respiratory insufficiency and their correction.

Adrenal Cortex Hormones↗
PubMed1978

[Therapy of pneumogenous respiratory insufficiency. Preliminary physiopathology].

A physiopathological approach to the treatment of chronic pneumogenous respiratory insufficiency is proposed. To this end, disturbances of the ventilatory and alveolocapillary stages of the pulmonary respiratory function are discussed. Particular attention to distribution and diffusion disturbances and the main diseases to which they give rise. A treatment program based on these premises is put forward.

Humans↗
PubMed1976

[Relations between atmospheric pollution and the respiratory tract].

After mentioning the close relationships between enviornmental pollution and the respiratory system, the various polluting compounds, from solid particles to fumes and gases, are reviewed, special attention being paid to the commonest types (sulphur and nitrogen compounds). Attention is called to two other polluting factors, asbestos and radioactivity, both of which are important in neoplastic pathology. The complexity of the air pollution problem in relation to respiratory pathology is stressed while stating that the most important problem remains that of prevention.

Air Pollutants↗
PubMed1975

[Patient population and length of stay in a pneumologic hospital].

The patient population of a phthisiopneumological hospital over the years 1972 and 1973 is reviewed. The mean stay of patients with lung T. B. is determined and the most frequent pictures are described. It is suggested, contrary to what is sometimes maintained, that hospitalisation is still a valid form of management for such subjects. Reference is made to the diseases most commonly encountered in the pneumological sections. Notes of a policy and health type are offered with respect to the mean stay and the establishment of departmental status in hopefully envisaged.

Acute Disease↗
PubMed1975

[Neural regulation of bronchial smooth muscle].

A brief account of the anatomical features of the smooth musculature of the entire bronchial tree is followed by an examination of the various components of the broncho-constrictor reflex. Stress is laid on the importance of the sympathetic and parasympathetic pathways in determining the reflex and the release of chemical mediators in the bronchi is discussed. Clinical situations leading to an enhanced reflex are described and their pathogenesis is explained. It is submitted, however, that existing knowledge of bronchospastic syndromes is still insufficiently clear. This explains the lack of success frequently encountered in their treatment.

Bronchi↗