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Biomedical subjects

A Pezza

Publications and source records attributed to A Pezza.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Thymidine kinase as a biological marker in neoplasms of the lung and mediastinum].

Thymidine kinase (TK) is a biological marker recently used in diagnosis and monitoring of pulmonary and mediastinal malignant neoplasms. Authors report more recent clinical evidences of literature and, in the meanwhile, they report their personal experiences about a 20 patients group suffering of lung cancer and Hodgkin disease. Their study demonstrates a good sensitivity of TK as biological marker of SCLC and a lower sensitivity in case of NSCLC and Hodgkin disease. It has been possible to contribute to establishment of normal range values, on account of 10 healthy volunteer group blood sample assays.

Aged↗
PubMedDate not supplied

[The usefulness of monoclonal antibodies in the diagnosis of lung carcinoma].

Monoclonal antibodies detection represented a turning point in field of immunological and biological research. Their application has rapidly extended at immunopathology as well as immunodiagnosis and immunotherapy fields. In oncological field monoclonal antibodies has proved a great usefulness in diagnosis of several districts neoplasm. Monoclonal antibodies are utilized in differential diagnosis of different histologic types of lung cancer; in bone marrow metastasis early detection; and, experimentally, in "in vivo" diagnosis of lung cancer via peripheral blood sample examination. Authors relate about more recent literature about this specific topic.

Antibodies, Monoclonal↗
PubMedDate not supplied

[Bronchoalveolar lavage in the diagnosis of cancer].

Bronchoalveolar lavage (BAL) is a widely used clinical procedure. To determine if BAL could provide useful information in the detection of cancer, 850 lavages from 421 patients having BAL for a variety of indications, 50 lavages in patients with Hodgkin's disease and 20 patients with breast cancer undergoing bon marrow transplant were reviewed. BALs were performed with the technique established by Rennard and coll. in which 5 successive 20 cc aliquots are infused in a wedge position. The return from the first aliquot was processed separately from the subsequent four aliquots. Diff-Quick stained cytocentrifuge preparations and Papanicolaou stained millipore filter preparations were analyzed. Thirty-five patients had biopsy-proven lung cancer. In 24 (68.6%) of these, BAL revealed cells diagnostic of malignancy. There were no false positives. Six out of 50 Hodgkin's disease patients had Reed Sternberg cells detected on BAL, and 7/20 breast cancer patients had malignant cells on BAL prior to chemotherapy. In summary, the routine performance of BAL, an easily performed and well-tolerated procedure, may prove to be useful in the routine assessment of patients for cancer.

Bronchoalveolar Lavage Fluid↗
PubMedDate not supplied

[The use of recombinant interferon alfa-2b in the follow-up of patients laryngectomized for advanced stage carcinoma].

The AA. report the results of an experimental investigation on 60 subjects who underwent surgery for advanced stage carcinoma of the glottic larynx and treated with alpha 2b recombinant interferon at the dosage of 3,000,000 ul three times a week, before a six-months follow-up. The patients were examined also as to the respiratory functionality and the monitoring of some biological markers of cancers (CEA, TPA, Ca 125, Ca 15.3). The AA. support the satisfactory tolerability of alpha interferon which showed expected side effects; these effects were controlled by the symptomatic treatment, and their metabolic parameters as well as the ones related to the respiratory functionality kept always their valves in the average. The monitoring of biological markers, seems to support a real usefulness in the treatment with alpha interferon, even if a statistically meaningful record couldn't be noticed.

Aged↗
PubMedDate not supplied

[A controlled clinical study of Pneumorel Retard tablets in the treatment of chronic bronchitis (author's transl)].

The authors studied the action of Pneumorel retard tablets in the treatment of chronic bronchitis, comparing 2 groups of 20 patients each, one group was prescribed 1 pneumorel retard tablet in the morning and evening and the other group was treated with a speciality associating proteolytic enzymes and balsamics; the 2 groups also received an antibiotic treatment. The duration of the treatments was 20 days, with controls at entry, 10 days and 20 days later. Pneumorel retard showed to be significantly more active on the criteria studied (cough, dyspnea, expectoration, signs of auscultation) and this more often than not from the 10th day of treatment. Clinical and biological tolerance was perfect concerning the hepatic sphere, gastrointestinal, renal or cardiovascular systems. The convenience of the use of Pneumorel retard is particularly indicated in the thorough long-term treatment of chronic bronchitis, in preventing episodes of over-infection, worsening the disease.

Adolescent↗