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Biomedical subjects

A Pingle

Publications and source records attributed to A Pingle.

14 recordsLinked to original sources
PubMed1990

High mortality among recipients of bought living-unrelated donor kidneys.

Between June, 1984, and May, 1988, 130 patients from three renal units in the United Arab Emirates and Oman went of their own accord to Bombay, where they bought, through brokers, kidneys from living unrelated Indian donors for US$2600-3300. 131 transplants were done, and the 122 patients who survived the perioperative period returned to their original renal units for follow-up. Altogether there were 25 deaths (16 before the end of 3 months, 4 in the next 3 months, and 4 more by the end of the first year), which gave a patient survival rate of 81.5% at 1 year. The patients who died had multiple complications, but infection was the commonest known cause of death. Patients were not properly instructed about their treatment, and little or no information was given to doctors following up the patients, criteria of suitability for transplantation were not strict, and patients were exposed to serious infections (including human immunodeficiency virus infection). In addition, the availability of living-donor programmes slows down attempts to establish cadaver-donor transplant programmes.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Ethics and commerce in live donor renal transplantation: classification of the issues.

Renal transplantation is now very successful. A shortage of kidneys continues to be a problem. Attempts to increase the supply have recently led to unethical practices, but the issues in the discussion of the ethics need clarification. We propose a classification that we believe will help to achieve this for living donor renal transplantation. This can be considered under five categories: (1) living-related donation; (2) emotionally related donation; (3) altruistic donation; (4) "rewarded" gifting; and (5) rampant commercialism. Ethical issues for categories 1, 2, and 3 are either esoteric or have been resolved. Category 4 needs further discussion and elucidation and should be the area of concentration. Category 5 we perceive to be unethical.

Altruism↗
PubMed1988

Reversibility of captopril-induced renal insufficiency after prolonged use in an unusual case of renovascular hypertension.

We report a case of severe hypertension with an occluded renal artery to a solitary kidney, who developed sudden deterioration of renal function following treatment with captopril. His renal function remained impaired but stable during 2 years' treatment with captopril but returned to pre-treatment levels soon after cessation of the drug. This indicates reversibility in captopril-induced renal failure even after its prolonged use and suggests that no organic damage occurs to glomerular arterioles following chronic ACE inhibition.

Acute Kidney Injury↗