Biomedical subjects
Publications and source records attributed to A Pinheiro.
SUMMARY: This report describes an algorithm (intensity-dependent selection of expression ratios or ISER) developed to analyse DNA array data by optimizing the selection of genes with the most significant variations in expression amongst two RNA samples. The algorithm is designed for use when little or no replication of array hybridizations is available.
AIM: To determine the prevalence of dental and oral lesions, as well as treatment need, in a group of HIV sero-positive Brazilians. In addition, to test the association between oral manifestation of HIV infection and age, sex, mode of transmission and drug therapy. METHOD: All HIV seropositive patients attending a dedicated dental clinic in Recife were invited to participate in the study. They were all examined by one trained and calibrated examiner and interviewed by one trained interviewer. RESULTS: 161 of 204 patients (78.9%) agreed to participate in this study. Most of the participants were male (76%), had acquired HIV sexually (74.5%), and were taking some form of antiretroviral therapy (70.8%). 33.5% had one or more oral manifestation of HIV. Candidiasis was the most common (28.6%), followed by hairy leukoplakia (9.3%), Kaposi sarcoma (2.5%), ulceration (2.5%), herpes simplex (1.2%), papiloma (0.6%), and 4.4% had periodontal disease. Only 1.2% reported xerostomia. There were no differences in the prevalence of oral manifestations of HIV infection between age groups, sexes, modes of transmission and types of drug therapy (P>0.05). The mean DMF-T score was 19 (SD 8) and 78.9% needed some form of dental treatment. CONCLUSIONS: While the prevalence of oral manifestations of HIV/AIDS was low in this sample of HIV seropositive Brazilians, dental status was poor and need for dental treatment was high.
This study was done to determine whether a relationship existed between maternal weight gain during pregnancy and the birth weight and if such a relationship did exist, to establish the minimum weight gain required for a normal birth weight baby. This was a retrospective study involving an audit of all antenatal records at a rural hospital and health centre. The records reviewed belonged to a period between '86-'99. About 2000 antenatal records were scanned and cases with complications and multiple pregnancy were excluded. The records reviewed pertained only to mothers who had delivered at this rural hospital. The final sample size was 935 mothers. The study revealed that a greater weight gain in second trimester resulted in a better birth weight (P < 0.05). Other factors that influenced the birth weight were: age (P < 0.001), regular antenatal check up (P < 0.05) and parity (P < 0.05).
The response of rat neocortical slices to electrical stimulation at the layer VI/white matter border was recorded using intrinsic signal optical imaging. The optical response of the slice is column-shaped, extends from layer VI to the pial surface, and is strongly correlated with the amplitude of simultaneously recorded evoked potentials. Spectral analysis revealed radially oriented spatial variations in the intensity of the optical signal with a period of 30-60 microm/cycle. Nissl-stained sections of slices also exhibited a radially oriented periodicity in optical density with the same period. We conclude that the periodic variations in the intrinsic optical signal correspond to stimulus-activated minicolumns.
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Various types of pulmonary eosinophilia have been known for several years. Chronic eosinophilic pneumonia (original word for Christoforidis and Molnar 1960) is a rare entity whose diagnosis is possible through clinical, laboratory and radiological data. Other non sophisticated data-CAT, bronchoalveolar lavage, transbronchial biopsy, transthoracic biopsy and even thoracotomy can be used. Seriousness can be very high, demanding an urgent diagnosis and treatment.
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