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Biomedical subjects

A Pipe

Publications and source records attributed to A Pipe.

26 records · Page 2Linked to original sources
PubMed1996

Tobacco addiction and hypertension.

The significance of smoking in the hypertensive patient may be unappreciated. The risk of hypertension may be tripled in such patients. Tobacco addiction may also compromise the treatment of hypertensives. The importance of smoking cessation for hypertensive smokers cannot be overemphasized and should be seen as fundamental. Nicotine replacement therapy (NRT), when used appropriately, can enhance the likelihood of cessation. All smokers, but particularly hypertensive smokers, should be advised to quit and offered specific and ongoing assistance in this respect.

Humans↗
PubMed1995

An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers.

The antisense activity and gene specificity of two classes of oligonucleotides (ONs) were directly compared in a highly controlled assay. One class of ONs has been proposed to act by targeting the degradation of specific RNAs through an RNase H-mediated mechanism and consists of C-5 propynyl pyrimidine phosphorothioate ONs (propyne-S-ON). The second class of antisense agents has been proposed to function by sterically blocking target RNA formation, transport or translation and includes sugar modified (2'-O-allyl) ONs and peptide nucleic acids (PNAs). Using a CV-1 cell based microinjection assay, we targeted antisense agents representing both classes to various cloned sequences localized within the SV40 large T antigen RNA. We determined the propyne-S-ON was the most potent and gene-specific agent of the two classes which likely reflected its ability to allow RNase H cleavage of its target. The PNA oligomer inhibited T Ag expression via an antisense mechanism, but was less effective than the propyne-S-ON; the lack of potency may have been due in part to the PNAs slow kinetics of RNA association. Interestingly, unlike the 2'-O-allyl ON, the antisense activity of the PNA was not restricted to the 5' untranslated region of the T Ag RNA. Based on these findings we conclude that PNAs could be effective antisense agents with additional chemical modification that will lead to more rapid association with their RNA target.

Allosteric Site↗
PubMed1995

Cardiovascular disease prevention: talking occurs at all levels--does understanding?

The magnitude of the health problems posed by cardiovascular disease is well known and represents a major public health challenge. Traditionally programmes of prevention have had a 'lifestyle' orientation, focusing on individual behaviours. Ironically, it may well be that profound societal changes, notably the agricultural and industrial revolutions, have largely been responsible in the most fundamental sense for the modern epidemic of cardiovascular disease. Thus attempts to deal with individually expressed behaviours alone may not be the most effective way to prevent the development of cardiovascular disease in our society. Ultimately, it will be the creation of social environments in which healthy behaviours are the norm that will have the most profound effect on the community's cardiovascular health. Misunderstandings abound. Politicians, while speaking favourably about the importance of prevention, do not match their rhetoric with resources. Many health professionals mistake 'risk-factor identification' with 'prevention'. Private industry has often confused or distorted public understanding in the process of marketing products deemed to have cardiovascular benefits. The public's awareness of many of the basic epidemiological realities concerning the prevention of cardiovascular disease is often sadly lacking. In spite of the misunderstandings, preventive approaches have played a significant role in the reduction of cardiovascular disease, a role that should become more prominent in the future.

Cardiovascular Diseases↗