Biomedical subjects

A Piziewicz

Publications and source records attributed to A Piziewicz.

16 recordsLinked to original sources

PubMed2001

The effect of betahistine on vestibular habituation: comparison of rotatory and sway habituation training.

This study was designed to investigate the effect of histaminergic agonists and antagonists on the acquisition of vestibular habituation. The experimental animals, pigeons, were subjected to unilateral rotatory and sway habituation training sessions. The habituation of postural reflexes and post-rotatory head nystagmus was assessed. Vestibular habituation in the control group was achieved by adopting the kinetic reflex posture after approximately 9 training sessions, and after 10 and 14 training sessions, respectively for 50% reduction of the total number of beats (TNB) and the duration of post-rotatory head nystagmus. In the sway adaptation test control pigeons needed nearly 15 training sessions while pigeons receiving betahistine adapted after approximately 8 sessions. Administration of histamine and, most notably, betahistine accelerated the process, while both H1 and H2 antagonists (clemastine, cimetidine) tended to retard it, indicating a less significant contribution of H2 receptors. The cholinergic agent physostigmine strongly retarded habituation while the anticholinergic agent scopolamine markedly accelerated it. In addition the adrenomimetic agent ephedrine also accelerated habituation while the adrenolytic agent droperidol retarded reduction of nystagmus beats. The results indicate that histaminergic receptors play a significant role in the vestibular habituation mechanism but are intricately involved with other types of receptors. Betahistine is clearly the agent of choice for attenuating vestibular effects.

Animals↗

PubMed2001

[Congenital cholesteatoma in children--case reports].

The authors present three cases of congenital cholesteatoma in children. In two cases primary surgery was curative, in third patient one year after first surgery the residual cholesteatoma was diagnosed, and second surgery was performed. Finally in all cases good anatomical and functional effect was obtained. The natural history of congenital cholesteatoma, as well as surgical techniques which can be applied depending on type and location of congenital cholesteatoma are discussed. The authors emphasise the importance of early recognition of the disease. Exploratory tympanotomy, or CT scan should be applied in all cases where suspected changes are observed during otoscopy.

Adolescent↗

PubMed2000

[Isolated sphenoiditis treated with endoscopic surgery in a child].

Isolated sphenoiditis in childhood is a rare entity which is often very difficult to diagnose with conventional techniques. The authors present a case of sphenoiditis in nine years old boy, where chronic rhinitis and persistent cephalqia where the main symptoms. The diagnosis was made on the base of computed tomography and nasal endoscopy. Because of lack of effect after pharmacological treatment the child was submitted to endoscopic surgery--sphenoethmoidectomy, which resulted it total recovery. The diagnosis, indications to computed tomography of paranasal sinuses in children, options of both conservative and surgical treatment and possible complications of the diseases are discussed.

Child↗

PubMed2000

[The vestibular system and migraine in children].

Migraine in childhood is relatively common disease. Although clinical practice and scientific publications recognize frequent association of migraine and vestibular disorders, relationships have yet to be well defined. In present study the vestibular function was extensively tested in 20 children suffering from migraine. All the patients underwent complete neurootological examination including tonal threshold audiometry, testing of vestibulo-spinal reflexes--Romberg and Unterberger-Fukuda tests, Dix-Halpike test for BPPV, videonystagmography. On videonystagmography each patient was evaluated regarding: calibration, spontaneous nystagmus, gaze nystagmus, eye tracking test, optokinetic and positional nystagmus, and caloric testing. The same procedure have been performed regarding control group comprised of 15 healthy. All the patients with migraine presented abnormalities in vestibular testing. Analysis of the results showed that: functional state of structures forming both visuo-ocular and vestibulo-ocular structures was altered in all the migraine patients evaluated in the study, pathological findings suggest mainly central localisation of vestibular dysfunction in children suffering from migraine, the number of pathological VNG findings seems not to be correlated with the type of migraine.

Adolescent↗

PubMed1993